延髄内側症候群。デジュリーヌ症候群
WordNet
- a pattern of symptoms indicative of some disease
- a complex of concurrent things; "every word has a syndrome of meanings"
PrepTutorEJDIC
- (疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/09 06:16:53」(JST)
[Wiki en表示]
| Medial medullary syndrome |
| Classification and external resources |
|
Medulla oblongata, shown by a transverse section passing through the middle of the olive. (Medial medullary syndrome can affect structures in lower left: especially #5, #6, #8.)
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| ICD-10 |
G46.3 |
| eMedicine |
emerg/834 |
Medial medullary syndrome, also known as inferior alternating syndrome, hypoglossal alternating hemiplegia, lower alternating hemiplegia,[1] or Dejerine syndrome,[2] is a type of alternating hemiplegia characterized by a set of clinical features resulting from occlusion of the anterior spinal artery. This results in the infarction of medial part of the medulla oblongata.
Contents
- 1 Pathophysiology
- 2 Presentation
- 3 See also
- 4 References
- 5 External links
Pathophysiology
The infarction leads to death of the ipsilateral medullary pyramid, the medial leminiscus, and the hypoglossal nerve fibers that pass through the medulla. The spinothalamic tract is spared because it is located more laterally in the brainstem and is not supplied by the anterior spinal artery, but rather by the vertebral and posterior inferior cerebellar arteries. The trigeminal nucleus is also spared, since most of it is higher up in the pons, and the spinal part of it found in the medulla is lateral to the infarct.
Presentation
The condition usually consists of:
| Description |
Source of damage |
Number on diagram |
| a deviation of the tongue to the side of the infarct on attempted protrusion, caused by ipsilateral muscle weakness. |
hypoglossal nerve fibers |
#8 |
| limb weakness (or hemiplegia, depending on severity), on the contralateral side of the infarct |
medullary pyramid and hence to the corticospinal fibers of the pyramidal tract |
#5 |
| a loss of discriminative touch, conscious proprioception, and vibration sense on the contralateral side of the infarct |
medial leminiscus |
#6 |
Human brainstem blood supply description. ASA is #13.
Sensation to the face is preserved, due to the sparing of the trigeminal nucleus.
The syndrome is said to be "alternating" because the lesion causes symptoms both contralaterally and ipsilaterally. Sensation of pain and temperature is preserved, because the spinothalamic tract is located more laterally in the brainstem and is also not supplied by the anterior spinal artery (instead supplied by the posterior inferior cerebellar arteries and the vertebral arteries).
See also
- Alternating hemiplegia of childhood
- Lateral medullary syndrome
References
- ^ "Atlas of Microscopic Anatomy: Section 17 - Central Nervous System. Plate 17.330 Medulla Oblongata". Retrieved 2007-06-07.
- ^ Yokota J, Amakusa Y, Tomita Y, Takahashi S (February 2003). "[The medial medullary infarction (Dejerine syndrome) following chiropractic neck manipulation]". No To Shinkei (in Japanese) 55 (2): 121–5. PMID 12684991.
External links
- http://isc.temple.edu/neuroanatomy/lab/lesions/14.htm
- http://www.neuropat.dote.hu/table/kereszt7.htm
|
CNS disease, Vascular disease: Cerebrovascular diseases (G45–G46 and I60–I69, 430–438)
|
|
Brain ischemia/
cerebral infarction
(ischemic stroke/TIA) |
| TACI, PACI |
- precerebral: Carotid artery stenosis
- cerebral: MCA
- ACA
- Amaurosis fugax
|
|
| POCI |
- precerebral: Anterior spinal artery syndrome
- Vertebrobasilar insufficiency
- Subclavian steal syndrome
- brainstem: medulla
- Medial medullary syndrome
- Lateral medullary syndrome
- pons
- Medial pontine syndrome/Foville's
- Lateral pontine syndrome/Millard-Gubler
- midbrain
- Weber's
- Benedikt
- Claude's
- cerebral: PCA
- Lacunar stroke
- Dejerine–Roussy syndrome
|
|
| General |
- cerebral: Cerebral venous sinus thrombosis
- CADASIL
- Binswanger's disease
- Transient global amnesia
|
|
|
Intracranial hemorrhage
(hemorrhagic stroke) |
| Extra-axial |
- Epidural
- Subdural
- Subarachnoid
|
|
| Cerebral/Intra-axial |
|
|
| Brainstem |
|
|
|
| Aneurysm |
- Cerebral aneurysm
- Intracranial berry aneurysm
- Charcot-Bouchard aneurysm
|
|
| Other/general |
|
|
|
|
anat (n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp
|
noco (m/d/e/h/v/s)/cong/tumr, sysi/epon, injr
|
proc, drug (N1A/2AB/C/3/4/7A/B/C/D)
|
|
|
|
anat (a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot
|
noco/syva/cong/lyvd/tumr, sysi/epon, injr
|
proc, drug (C2s+n/3/4/5/7/8/9)
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|
|
|
Lesions of spinal cord and brain
|
|
Spinal cord/
vascular myelopathy |
- sensory: Sensory ataxia
- Tabes dorsalis
- motor: Motor neurone disease
- mixed: Brown-Séquard syndrome
- cord syndrome (Posterior
- Anterior
- Central/Syringomyelia)
- Subacute combined degeneration of spinal cord (B12)
- Cauda equina syndrome
- Anterior spinal artery syndrome
|
|
| Brainstem |
|
Medulla (CN 8, 9, 10, 12)
|
- Lateral medullary syndrome/Wallenberg
- Medial medullary syndrome/Dejerine
|
|
|
Pons (CN 5, 6, 7, 8)
|
- Lateral pontine syndrome (AICA) (lateral)
- Medial pontine syndrome/Millard-Gubler syndrome
- basilar/Foville's syndrome
- Locked-in syndrome (ventral)
- Internuclear ophthalmoplegia
- One and a half syndrome
|
|
|
Midbrain (CN 3, 4)
|
- Weber's syndrome
- Benedikt syndrome
- Parinaud's syndrome
- Nothnagel's syndrome
- Claude's syndrome
|
|
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Other
|
|
|
|
| Cerebellum |
- lateral (Dysmetria
- Dysdiadochokinesia
- Intention tremor)
- medial (Cerebellar ataxia)
|
|
| Basal ganglia |
- Chorea
- Dystonia
- Parkinson's disease
|
|
| Cortex |
- ACA syndrome
- MCA syndrome
- PCA syndrome
- frontal lobe: Expressive aphasia
- Abulia
- parietal lobe: Receptive aphasia
- Hemispatial neglect
- Gerstmann syndrome
- Astereognosis
- occipital lobe: Bálint's syndrome
- Cortical blindness
- Pure alexia
- temporal lobe: Cortical deafness
- Prosopagnosia
|
|
| Other |
- Subclavian steal syndrome
- Upper motor neurone lesion (Clasp-knife response)
- Lower motor neurone lesion
|
|
|
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anat (n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp
|
noco (m/d/e/h/v/s)/cong/tumr, sysi/epon, injr
|
proc, drug (N1A/2AB/C/3/4/7A/B/C/D)
|
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UpToDate Contents
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English Journal
- A sequence-based computational approach to predicting PDZ domain-peptide interactions.
- Nakariyakul S1, Liu ZP, Chen L.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 Jan;1844(1 Pt B):165-70. doi: 10.1016/j.bbapap.2013.04.008. Epub 2013 Apr 20.
- The PDZ domain is one of the most ubiquitous protein domains that is involved in coordinating signaling complex formation and protein networking by reversibly interacting with multiple binding partners. It has been linked to many devastating diseases such as avian influenza, Fraser syndrome, Usher s
- PMID 23608946
- Karmacharya P1, Shah K2, Pathak R1, Ghimire S3, Alweis R1.
- Journal of community hospital internal medicine perspectives.J Community Hosp Intern Med Perspect.2014 Feb 17;4. doi: 10.3402/jchimp.v4.23148. eCollection 2014.
- Central Poststroke Pain syndrome (CPSP) can occur due to disruption of the somatosensory pathways of the brain at any level such as the thalamus, medulla, or cerebral cortex. It is characterized by sensory abnormalities and hyperesthesia in the part of the body correlating to the central lesion. The
- PMID 24596647
- Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.
- Tanisawa K1, Mikami E, Fuku N, Honda Y, Honda S, Ohsawa I, Ito M, Endo S, Ihara K, Ohno K, Kishimoto Y, Ishigami A, Maruyama N, Sawabe M, Iseki H, Okazaki Y, Hasegawa-Ishii S, Takei S, Shimada A, Hosokawa M, Mori M, Higuchi K, Takeda T, Higuchi M, Tanaka M.
- BMC genomics.BMC Genomics.2013 Apr 15;14:248. doi: 10.1186/1471-2164-14-248.
- BACKGROUND: Senescence-accelerated mice (SAM) are a series of mouse strains originally derived from unexpected crosses between AKR/J and unknown mice, from which phenotypically distinct senescence-prone (SAMP) and -resistant (SAMR) inbred strains were subsequently established. Although SAMP strains
- PMID 23586671
Japanese Journal
Related Links
- Dejerine syndrome symptoms, causes, diagnosis, and treatment information for Dejerine syndrome (Medial Medullary Syndrome) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, prevention, and ...
- Dejerine–Roussy syndrome. 6 likes · 1 talking about this. ... Want to like this page? Sign up for Facebook to get started. Sign Up It's free and anyone can join. Already a member? Log in. This Page is automatically generated based ...
★リンクテーブル★
[★]
- 同
- medial medullary syndrome, MMS
- 同
- デジュリーヌ症候群 Dejerine syndrome
- 関
- 舌下神経交叉性片麻痺症候群。延髄外側症候群 LMS = ワレンベルグ症候群
[show details]
[★]