WordNet

the 4th letter of the Roman alphabet (同)d
a base found in DNA and RNA and derived from pyrimidine; pairs with guanine (同)C

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1. 母体血中の無細胞胎児核酸を使った出生前診断 prenatal diagnosis using cell free fetal nucleic acids in maternal blood
2. 分子遺伝学の原理 principles of molecular genetics
3. 遺伝性疾患の基本原則 basic principles of genetic disease
4. 淋菌感染症の診断 diagnosis of gonococcal infections
5. ポリメラーゼ連鎖反応(PCR) polymerase chain reaction

Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics?

Gerovska D1, Araúzo-Bravo MJ2.
Molecular human reproduction.Mol Hum Reprod.2016 Jan 5. pii: gav072. [Epub ahead of print]
STUDY HYPOTHESIS: Does primordial germ cell (PGC) activation start before mouse embryo implantation, and does the possible regulation of the DNA (cytosine-5-)-methyltransferase 3-like (Dnmt3l) by transcription factor AP-2, gamma (TCFAP2C) have a role in this activation and in the primitive endoderm
PMID 26740066

A 7-Deazaadenosylaziridine Cofactor for Sequence-Specific Labeling of DNA by the DNA Cytosine-C5 Methyltransferase M.HhaI.

Kunkel F1, Lurz R2, Weinhold E3.
Molecules (Basel, Switzerland).Molecules.2015 Nov 23;20(11):20805-22. doi: 10.3390/molecules201119723.
DNA methyltransferases (MTases) catalyze the transfer of the activated methyl group of the cofactor S-adenosyl-l-methionine (AdoMet or SAM) to the exocyclic amino groups of adenine or cytosine or the C5 ring atom of cytosine within specific DNA sequences. The DNA adenine-N6 MTase from Thermus aquati
PMID 26610450

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy.

Peng D1, Kryczek I1,2, Nagarsheth N1,2, Zhao L3, Wei S1, Wang W1, Sun Y4, Zhao E1, Vatan L1, Szeliga W1, Kotarski J5, Tarkowski R5, Dou Y4, Cho K4,6, Hensley-Alford S7, Munkarah A7, Liu R6,8, Zou W1,2,6,9.
Nature.Nature.2015 Nov 12;527(7577):249-53. doi: 10.1038/nature15520. Epub 2015 Oct 26.
Epigenetic silencing including histone modifications and DNA methylation is an important tumorigenic mechanism. However, its role in cancer immunopathology and immunotherapy is poorly understood. Using human ovarian cancers as our model, here we show that enhancer of zeste homologue 2 (EZH2)-mediate
PMID 26503055