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English Journal

A Fine-Tuned Interaction between Trimeric Autotransporter Haemophilus Surface Fibrils and Vitronectin Leads to Serum Resistance and Adherence to Respiratory Epithelial Cells.

Singh B1, Su YC, Al-Jubair T, Mukherjee O, Hallström T, Mörgelin M, Blom AM, Riesbeck K.
Infection and immunity.Infect Immun.2014 Jun;82(6):2378-89. doi: 10.1128/IAI.01636-13. Epub 2014 Mar 24.
Haemophilus influenzae type b (Hib) escapes the host immune system by recruitment of the complement regulator vitronectin, which inhibits the formation of the membrane attack complex (MAC) by inhibiting C5b-C7 complex formation and C9 polymerization. We reported previously that Hib acquires vitronec
PMID 24664511

Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction.

Woollard SM1, Bhargavan B1, Yu F2, Kanmogne GD1.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.J Cereb Blood Flow Metab.2014 Mar 26. doi: 10.1038/jcbfm.2014.54. [Epub ahead of print]
HIV-1 genetic differences influence viral replication and progression to AIDS. HIV-1 circulating recombinant form (CRF)02_AG is the predominant viral subtype infecting humans in West and Central Africa, but its effects on HIV neuropathogenesis are not known. In the present study, we investigated the
PMID 24667918

Cai Y1, Yang Q2, Tang Y2, Zhang M3, Liu H4, Zhang G3, Deng Q5, Huang J6, Gao Z7, Zhou B3, Feng CG8, Chen X2.
PloS one.PLoS One.2014 Mar 19;9(3):e92340. doi: 10.1371/journal.pone.0092340. eCollection 2014.
BACKGROUND: Complement functions as an important host defense system and complement C5 and C7 have been implicated in immunopathology of tuberculosis. However, little is known about the role of other complement components in tuberculosis.METHODS: Complement gene expression in peripheral blood mononu
PMID 24647646

Identification of cDNA Sequences Encoding the Complement Components of Zebrafish (Danio rerio)

Vo Kha Tam,Tsujikura Masakazu,Somamoto Tomonori,Nakano Miki
Journal of the Faculty of Agriculture, Kyushu University 54(2), 373-387, 2009-10-29
… Zebrafish can be utilized for immunological research as a fish model that allows gene targeting, but lacks enough molecular and sequence information on the complement system, a humoral innate immune factor. … The present study aimed at identification of all the major complement components at the molecular level with phylogenetic evidence. …
NAID 120001766563

Characterization of the Soluble Membrane Attack Complex (SMAC) of Carp (Cyprinus carpio) Complement

Nakao Miki,Uemura Takeshi,Yano Tomoki
九州大学農学部紀要 48(1/2), 127-134, 2003-10
… The membrane attack complex (MAC) of mammalian complement, which is composed of complement components,C5b, C6, C7, C8 and C9, shows cytolytic activity by distributing the structure of cytoplasmic mambrane. … The soluble form of the membtane attack complex, termed SMAC, of the complement system is innert unlike the membtane attack complex formed on target cell membranes. …
NAID 110001800264

NISHIMUKAI Hiroaki,NISHIMURA Koji,ORIMOTO Chitoshi,OKIURA Tatsuyuki,FUJII Kenji,FUKUMORI Yasuo,HARIHARA Shinji
Legal medicine 5, S198-S200, 2003-03-01
NAID 50000252313