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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/19 15:40:12」(JST)

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Arachidonate 12-lipoxygenase (EC 1.13.11.31) is an enzyme that catalyzes the chemical reaction

arachidonate + O₂ (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate

Thus, the two substrates of this enzyme are arachidonate and oxygen, whereas its product is (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is arachidonate:oxygen 12-oxidoreductase. Other names in common use include Delta12-lipoxygenase, 12-lipoxygenase, 12Delta-lipoxygenase, C-12 lipoxygenase, 12S-lipoxygenase, leukotriene A4 synthase, and LTA4 synthase. This enzyme participates in arachidonic acid metabolism. At least one compound, 3-methoxytropolone is known to inhibit this enzyme.

References

Hamberg M, Samuelsson B (1974). "Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets". Proc. Natl. Acad. Sci. U.S.A. 71 (9): 3400–4. doi:10.1073/pnas.71.9.3400. PMC 433780. PMID 4215079.
Nugteren DH (1975). "Arachidonate lipoxygenase in blood platelets". Biochim. Biophys. Acta. 380 (2): 299–307. doi:10.1016/0005-2760(75)90016-8. PMID 804329.
Wallach DP, Brown VR (1981). "A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases". Biochim. Biophys. Acta. 663 (2): 361–72. doi:10.1016/0005-2760(81)90165-x. PMID 6783111.

UpToDate Contents

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English Journal

Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer.

Li S, Zhao X, Wu Z, Li Y, Zhu L, Cui B, Dong X, Tian S, Hu F, Zhao Y.SourceDepartment of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang Province, People's Republic of China.
Familial cancer.Fam Cancer.2013 Dec;12(4):755-65. doi: 10.1007/s10689-013-9659-2.
Cyclooxygenase-2 (COX-2), 12-lipoxygenase (12-LOX) and phospholipaseA2 (PLA2) played important roles in the modulation of apoptosis, angiogenesis, carcinogenesis and invasion of colorectal cancer (CRC). The polymorphisms in COX-2, 12-LOX and PLA2 may affect their roles. Therefore, we investigated if
PMID 23715757

Systemic Disease during Streptococcus pneumoniae Acute Lung Infection Requires 12-Lipoxygenase-Dependent Inflammation.

Bhowmick R, Tin Maung NH, Hurley BP, Ghanem EB, Gronert K, McCormick BA, Leong JM.SourceDepartment of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111;
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2013 Nov 15;191(10):5115-23. doi: 10.4049/jimmunol.1300522. Epub 2013 Oct 2.
Acute pulmonary infection by Streptococcus pneumoniae is characterized by high bacterial numbers in the lung, a robust alveolar influx of polymorphonuclear cells (PMNs), and a risk of systemic spread of the bacterium. We investigated host mediators of S. pneumoniae-induced PMN migration and the role
PMID 24089193

Development of a new colorimetric assay for lipoxygenase activity.

Lu W, Zhao X, Xu Z, Dong N, Zou S, Shen X, Huang J.SourceShanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Analytical biochemistry.Anal Biochem.2013 Oct 15;441(2):162-8. doi: 10.1016/j.ab.2013.06.007. Epub 2013 Jun 26.
Lipoxygenases (LOXs) are a family of non-heme iron-containing dioxygenases that catalyze the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure. A rapid and reliable colorimetric assay for determination of the activity of three human functional lipoxygenase isoforms (5-lipoxy
PMID 23811155

Japanese Journal

Comparison of 12-lipoxygenase expression in vascular smooth muscle cells from old normotensive Wistar-Kyoto rats with spontaneously hypertensive rats

KIM Hye Young,JEONG Dae Won,PARK Ho Sun,LEE Tae Yoon,KIM Hee Sun
Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 36(1), 65-73, 2013-01-01
NAID 10031163287

アラキドン酸12-リポキシゲナーゼによって誘発された酸化ストレスと炎症は，糖尿病性心筋症の発症を促進する (第129回成医会総会一般演題)

鈴木博史,坂本昌也,香山洋介,井内裕之,東條克能,吉村道博,宇都宮一典
東京慈恵会医科大学雑誌 127(6), 236-236, 2012-11-15
NAID 120005104551

Angiotensin II inhibits chemokine CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats

YUN Young Hyun,KIM Hye Young,DO Byung Soo,KIM Hee Sun
Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 34(12), 1313-1320, 2011-12-01
NAID 10030278057

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arachidonate 12-lipoxygenase
Identifiers
EC number	1.13.11.31
CAS number	82391-43-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
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