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  • Atypical presentations of genital herpes simplex virus in HIV-1 and HIV-2 effectively treated by imiquimod.
  • McKendry A1, Narayana S2, Browne R2.
  • International journal of STD & AIDS.Int J STD AIDS.2015 May;26(6):441-3. doi: 10.1177/0956462414538951. Epub 2014 Jun 9.
  • Atypical presentations of genital herpes simplex virus have been described in HIV. We report two cases with hypertrophic presentations which were effectively treated with imiquimod, one of which is the first reported case occurring in a patient with HIV-2. © The Author(s) 2014 Reprints and permissi
  • PMID 24912536
  • Imiquimod-induced AMPK activation causes translation attenuation and apoptosis but not autophagy.
  • Wang ST1, Huang SW1, Kao JK2, Liang SM3, Chen YJ4, Chen YY1, Wu CY5, Shieh JJ6.
  • Journal of dermatological science.J Dermatol Sci.2015 May;78(2):108-16. doi: 10.1016/j.jdermsci.2015.02.008. Epub 2015 Feb 23.
  • BACKGROUND: AMP-activated protein kinase (AMPK), a principal intracellular energy sensor, plays a crucial role in cell growth, proliferation, apoptosis and autophagy. Imiquimod (IMQ) directly exhibits anti-tumor activity through the induction of apoptosis and autophagic cell death.OBJECTIVE: To eval
  • PMID 25766763
  • Inhibitory effect of cucurbitacin B on imiquimod-induced skin inflammation.
  • Li ZJ1, Shin JM1, Choi DK1, Lim SK1, Yoon TJ2, Lee YH3, Sohn KC1, Im M1, Lee Y1, Seo YJ1, Kim CD1, Lee JH4.
  • Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Apr 17;459(4):673-8. doi: 10.1016/j.bbrc.2015.03.001. Epub 2015 Mar 10.
  • Psoriasis is a common skin disease, of which pathogenesis involves the increase of inflammatory reaction in epidermal cells. In an attempt to find therapeutics for psoriasis, we found that cucurbitacin B has an inhibitory potential on imiquimod-induced inflammation of keratinocytes. Cucurbitacin B s
  • PMID 25767074


  • 症例 5%イミキモドクリームで加療したボーエン様丘疹症の1例
  • 加瀬 貴美,黄倉 真恵,山下 利春
  • 西日本皮膚科 = The Nishinihon journal of dermatology : 日本皮膚科学会西部支部機関誌 74(6), 619-622, 2012-12-00
  • NAID 40019534398
  • イミキモドクリームが奏効した乳房外パジェット病の1例
  • 松澤 高光,小川 陽一,猪爪 隆史 [他]
  • 日本皮膚科学会雑誌 = The Japanese journal of dermatology 122(12), 2885-2890, 2012-12-00
  • NAID 40019487329
  • 症例 イミキモドが奏効した炎症性線状疣贅状表皮母斑の1例
  • 豊田 徳子,小寺 雅也,臼田 俊和 [他]
  • 皮膚科の臨床 54(5), 753-756, 2012-05-00
  • NAID 40019311559


推奨文:5% imiquimodクリームは十分に有用であり、とくに表在型基底細胞癌の手術不能例では適応を検討する価値がある。ただし、本邦では本剤は今のところ個人輸入でしか購入できない。
Imiquimod (R837), an imidazoquinoline amine analog to guanosine, is an immune response modifier with potent indirect antiviral activity. The antiviral activity of imiquimod was first shown in guinea pigs infected with herpes simplex ...