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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/03/24 18:07:56」(JST)

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  • Cdc45-ssDNA interaction is important for stalling the helicase during replication stress.
  • Bruck I, Kaplan DL.SourceFlorida State University College of Medicine, United States.
  • The Journal of biological chemistry.J Biol Chem.2013 Feb 4. [Epub ahead of print]
  • Replicative polymerase stalling is coordinated with replicative helicase stalling in eukaryotes, but the mechanism underlying this coordination is not known. Cdc45 activates the Mcm2-7 helicase. We report here that Cdc45 from budding yeast binds tightly to long (>40 nucleotides) genomic single-
  • PMID 23382391
  • Hydroxyurea treatment decreases glomerular hyperfiltration in children with sickle cell anemia.
  • Aygun B, Mortier NA, Smeltzer MP, Shulkin BL, Hankins JS, Ware RE.SourceDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee.
  • American journal of hematology.Am J Hematol.2013 Feb;88(2):116-9. doi: 10.1002/ajh.23365. Epub 2012 Dec 17.
  • Glomerular hyperfiltration and microalbuminuria/proteinuria are early manifestations of sickle nephropathy. The effects of hydroxyurea therapy on these renal manifestations of sickle cell anemia (SCA) are not well defined. Our objective was to investigate the effects of hydroxyurea on glomerular fil
  • PMID 23255310
  • Comparison of hematologic measurements between local and central laboratories: Data from the BABY HUG trial.
  • Kalpatthi R, Thompson B, Lu M, Wang WC, Patel N, Kutlar A, Howard T, Luchtman-Jones L, Miller ST; for the BABY HUG Investigators.SourceChildren's Mercy Hospitals and Clinics, Kansas City, MO, USA. Electronic address: rvkalpatthi@cmh.edu.
  • Clinical biochemistry.Clin Biochem.2013 Feb;46(3):278-281. doi: 10.1016/j.clinbiochem.2012.10.032. Epub 2012 Oct 31.
  • OBJECTIVES: To investigate the concordance of blood count indices measured locally and at a central laboratory.DESIGN AND METHODS: In a multi-center clinical trial of hydroxyurea therapy in infants with sickle cell anemia (BABY HUG), the concordance between blood count indices measured locally and a
  • PMID 23123915


  • Interference in DNA Replication Can Cause Mitotic Chromosomal Breakage Unassociated with Double-Strand Breaks
  • Fujita Mari,Sasanuma Hiroyuki,Yamamoto Kimiyo N.,Harada Hiroshi,Kurosawa Aya,Adachi Noritaka,Omura Masato,Hiraoka Masahiro,Takeda Shunichi,Hirota Kouji
  • PLoS ONE 8(4), 2013-04-03
  • … We measured the number of chromosomal breaks induced by three replication-blocking agents (aphidicolin, 5-fluorouracil, and hydroxyurea) in DSB-repair-proficient wild-type cells and cells deficient in both homologous recombination and nonhomologous end-joining (the two major DSB-repair pathways). …
  • NAID 120005244257
  • Monocytic Crisis of Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitor
  • Tsunemine Hiroko,Arima Hiroshi,Itoh Kiminari,Sakane-Ishikawa Emiko,Akasaka Hiroshi,Kodaka Taiichi,Takahashi Takayuki
  • Journal of Clinical and Experimental Hematopathology 53(3), 227-233, 2013
  • … He was consequently treated with hydroxyurea with partial hematological remission until June 2008. …
  • NAID 130003383998
  • Genotype-phenotype relationship of patients with β-thalassemia taking hydroxyurea : a 13-year experience in Iran
  • International journal of hematology 95(1), 51-56, 2012-01-01
  • NAID 10030266769


ヒドロキシカルバミド(Hydroxycarbamide あるいは Hydroxyurea ;ヒドロキシウレア、 ヒドロキシ尿素とも言う)とは、1869年にドイツのDreslerらによって合成された尿素 誘導体であり、代謝拮抗剤に分類される抗がん剤である。商品名は、ハイドレア( ブリストル・ ...
Features information about dosage, usage, warnings, and side effects.


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hydroxyurea, HU
(化学名)ヒドロキシ尿素、(一般名)ヒドロキシカルバミド hydroxycarbamide、ハイドロキシウレア
ハイドレア Hydrea, Mylocel

  • ヒドロキシ尿素により胎児ヘモグロビンの増加するらしい。