熱ショック応答

WordNet

strike with horror or terror; "The news of the bombing shocked her"
(pathology) bodily collapse or near collapse caused by inadequate oxygen delivery to the cells; characterized by reduced cardiac output and rapid heartbeat and circulatory insufficiency and pallor; "loss of blood is an important cause of shock"
subject to electrical shocks
the violent interaction of individuals or groups entering into combat; "the armies met in the shock of battle" (同)impact
an unpleasant or disappointing surprise; "it came as a shock to learn that he was injured" (同)blow
an instance of agitation of the earths crust; "the first shock of the earthquake came shortly after noon while workers were at lunch" (同)seismic disturbance
a bushy thick mass (especially hair); "he had an unruly shock of black hair"
a pile of sheaves of grain set on end in a field to dry; stalks of Indian corn set up in a field; "corn is bound in small sheaves and several sheaves are set up together in shocks"; "whole fields of wheat in shock"
surprise greatly; knock someones socks off; "I was floored when I heard that I was promoted" (同)floor, ball over, blow out of the water, take aback
strike with disgust or revulsion; "The scandalous behavior of this married woman shocked her friends" (同)offend, scandalize, scandalise, appal, appall, outrage
collect or gather into shocks; "shock grain"
collide violently
provide with heat; "heat the house"
a form of energy that is transferred by a difference in temperature (同)heat energy
make hot or hotter; "the sun heats the oceans"; "heat the water on the stove" (同)heat_up
gain heat or get hot; "The room heated up quickly" (同)hot up, heat_up
the trait of being intensely emotional (同)warmth, passion
the sensation caused by heat energy (同)warmth
a preliminary race in which the winner advances to a more important race
a result; "this situation developed in response to events in Africa"
a phrase recited or sung by the congregation following a versicle by the priest or minister
the manner in which an electrical or mechanical device responds to an input signal or a range of input signals
the 5th letter of the Hebrew alphabet
marked by emotional heat; vehement; "a heated argument"
made warm or hot (`het is a dialectal variant of `heated' (同)heated up, het, het_up

PrepTutorEJDIC

〈C〉(衝突・爆発などの)『衝撃』,(地震の)震動,電撃 / 〈C〉〈U〉(精神的)『打撃』,ショック / 〈U〉ショック症 / 《しばしば受動態で》〈人〉‘を'『ぎょっとさせる』,ひどく驚かせる / (治療のため)〈人・動物〉‘に'電気ショクを与える
(乾燥させるために立てかけた)穀類の刈り束 / 〈穀類〉‘を'刈り束にする
(髪の毛の)もじゃもじゃの固まり《+『of』+『名』》
〈U〉『熱さ』,『暑さ』,熱い状態 / 〈U〉熱度,温度 / 〈U〉(家などの)暖房装置 / 〈U〉熱心,熱烈;(物事の)最高潮《+『of』+『名』》 / 〈U〉(エネルギーとしての)熱 / 〈C〉(競技の)1回,1ラウンド / …‘を'『熱する』,暖める《+『up』+『名,』+『名』+『up』》 / …‘を'興奮させる,怒らせる《+『up』+『名,』+『名』+『up』》 / 熱くなる,暖まる《+『up』》
（雌の）発情（in heatとして使う）・金・銭・緊迫、プレッシャー、批判、批評、警察の追跡
〈C〉(…に対する)『返事』,『返答』《+『to』+『名』》 / 〈C〉〈U〉(…に対する)『反応』,『反響』《『to』+『名』》 / 〈C〉応答歌,応唱(牧師にならって合唱隊・会衆が短い祈り・歌を応答すること)
彼は,彼が / 《指す人の性別が分からないか,または分かる必要のない場合に》その人,あの人,自分 / 《he who(that)の形で》《文》…するものはだれでも / (動物の)おす(雄)
鬼ごっこ(tag,tick,tig)
熱せられた / 興奮した,怒った

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/20 16:01:54」(JST)

wiki en

In biochemistry, heat shock is the effect of subjecting a cell to a higher temperature than that of the ideal body temperature of the organism from which the cell line was derived.

Heat shock response

The cellular response to heat shock includes the transcriptional up-regulation of genes encoding heat shock proteins (HSPs) as part of the cell's internal repair mechanism.^[1] They are also called stress-proteins.^[2] and respond to heat, cold and oxygen deprivation by activating several cascade pathways. HSPs are also present in cells under perfectly normal conditions.^[2] Some HSPs, called chaperones, ensure that the cell’s proteins are in the right shape and in the right place at the right time.^[1]^[2] For example, HSPs help new or misfolded proteins to fold into their correct three-dimensional conformations, which is essential for their function.^[2] They also shuttle proteins from one compartment to another inside the cell, and target old or terminally misfolded proteins to proteases for degradation.^[2] Heat shock proteins are also believed to play a role in the presentation of pieces of proteins (or peptides) on the cell surface to help the immune system recognize diseased cells.^[3]

The up-regulation of HSPs during heat shock is generally controlled by a single transcription factor; in eukaryotes this regulation is performed by heat shock factor (HSF), while σ³² is the heat shock sigma factor in Escherichia coli.^[1]

Inducing heat shock

In fish that survive at 0°C, heat shock can be induced with temperatures as low as 5°C, whereas thermophilic bacteria that proliferate at 50°C will not express heat shock proteins until temperatures reach approximately 60°C.^[4] The process of heat shocking can be done in a CO₂ incubator, O₂ incubator, or a hot water bath.

References

^ ^a ^b ^c Guisbert, E., Yura, T., Rhodius, V.A., and Gross, C.A. 2008. Convergence of molecular, modeling and systems approaches for an understanding of the Escherichia coli heat shock response. Microbiol. Mol. Biol. Rev. 72: 545-554. doi:10.1128/MMBR.00007-08
^ ^a ^b ^c ^d ^e Vabulas, R.M,, Raychaudhuri, S., Hayer-Hartl, M. and Hartl, F.U. 2010. Protein Folding in the Cytoplasm and the Heat Shock Response. Cold Spring Harb. Perspect. Biol. doi:10.1101/cshperspect.a004390
^ Tsan, M. and Gao, B. 2009. Heat shock proteins and immune system. Journal of Leukocyte Biology. 85( 6): 905-910. doi:10.1189/jlb.0109005.
^ Lindquist, S. and Craig, E.A. 1988. The Heat-Shock Proteins. Annual Review of Genetics. 22: 631-677.[1] doi:10.1146/annurev.ge.22.120188.003215

This protein-related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 敗血症性ショック：小児における初期評価およびマネージメント septic shock initial evaluation and management in children
2. 小児における熱射病 heat stroke in children
3. 成人における重度高熱（熱射病） severe hyperthermia heat stroke in adults
4. 連鎖球菌性毒素性ショック症候群の疫学、臨床症状、および診断 epidemiology clinical manifestations and diagnosis of streptococcal toxic shock syndrome
5. 成人におけるショック：種類、症状、および診断的アプローチ shock in adults types presentation and diagnostic approach

English Journal

Neurotoxicity induced by arsenic in Gallus Gallus: Regulation of oxidative stress and heat shock protein response.

Zhao P1, Guo Y2, Zhang W2, Chai H2, Xing H3, Xing M4.
Chemosphere.Chemosphere.2017 Jan;166:238-245. doi: 10.1016/j.chemosphere.2016.09.060. Epub 2016 Sep 30.
Arsenic, a naturally occurring heavy metal pollutant, is one of the functioning risk factors for neurological toxicity in humans. However, little is known about the effects of arsenic on the nervous system of Gallus Gallus. To investigate whether arsenic induce neurotoxicity and influence the oxidat
PMID 27697713

Differentially expressed transcripts in stomach of Penaeus monodon in response to AHPND infection.

Soonthornchai W1, Chaiyapechara S2, Klinbunga S2, Thongda W3, Tangphatsornruang S4, Yoocha T4, Jarayabhand P5, Jiravanichpaisal P2.
Developmental and comparative immunology.Dev Comp Immunol.2016 Dec;65:53-63. doi: 10.1016/j.dci.2016.06.013. Epub 2016 Jun 20.
Acute Hepatopancreatic Necrosis Disease (AHPND) is an emerging disease in aquacultured shrimp caused by a pathogenic strain of Vibrio parahaemolyticus. As with several pathogenic bacteria, colonization of the stomach appeared to be the initial step of the infection for AHPND-causing Vibrio. To under
PMID 27339467

Effect of thermal dose on heat shock protein expression after radio-frequency ablation with and without adjuvant nanoparticle chemotherapies.

Moussa M1, Goldberg SN1,2, Kumar G1, Levchenko T3, Torchilin V3, Ahmed M1.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.Int J Hyperthermia.2016 Dec;32(8):829-841. Epub 2016 Sep 6.
PURPOSE: The aim of this study was to evaluate the effect of different radio-frequency ablation (RFA) thermal doses on coagulation and heat shock protein (HSP) response with and without adjuvant nanotherapies.MATERIALS AND METHODS: First, Fischer rats were assigned to nine different thermal doses of
PMID 27600101