出典: meddic


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「a gastrointestinal hormone produced by epithelial cells lining the fundus of the stomach; appears to be a stimulant for appetite and feeding, but is also a strong stimulant of growth hormone secretion from the anterior pituitary」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/06/08 22:59:26」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/09/05 10:42:44」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/10/01 00:37:52」(JST)

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  • Effects of weight loss diet therapy on anthropometric measurements and biochemical variables in schizophrenic patients.
  • Urhan M1, Ergün C, Aksoy M, Ayer A.
  • Nordic journal of psychiatry.Nord J Psychiatry.2015 Jul;69(5):323-30. doi: 10.3109/08039488.2014.981288. Epub 2015 May 18.
  • BACKGROUND: Prevalence of obesity in schizophrenic patients is two to three times higher than in the general population and unhealthy dietary patterns, a sedentary lifestyle and antipsychotic medication use may contribute to the higher levels of obesity among schizophrenic patients.AIMS: We evaluate
  • PMID 25981354
  • Ghrelin-reactive immunoglobulins and anxiety, depression and stress-induced cortisol response in adolescents. The TRAILS study.
  • François M1, Schaefer JM2, Bole-Feysot C1, Déchelotte P1, Verhulst FC2, Fetissov SO3.
  • Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2015 Jun 3;59:1-7. doi: 10.1016/j.pnpbp.2014.12.011. Epub 2015 Jan 3.
  • BACKGROUND: Ghrelin, a hunger hormone, has been implicated in the regulation of stress-response, anxiety and depression. Ghrelin-reactive immunoglobulins (Ig) were recently identified in healthy and obese humans showing abilities to increase ghrelin's stability and orexigenic effects. Here we studie
  • PMID 25562566
  • Appetite and gut hormone responses to moderate-intensity continuous exercise versus high-intensity interval exercise, in normoxic and hypoxic conditions.
  • Bailey DP1, Smith LR2, Chrismas BC2, Taylor L2, Stensel DJ3, Deighton K3, Douglas JA3, Kerr CJ4.
  • Appetite.Appetite.2015 Jun;89:237-45. doi: 10.1016/j.appet.2015.02.019. Epub 2015 Feb 17.
  • This study investigated the effects of continuous moderate-intensity exercise (MIE) and high-intensity interval exercise (HIIE) in combination with short exposure to hypoxia on appetite and plasma concentrations of acylated ghrelin, peptide YY (PYY), and glucagon-like peptide-1 (GLP-1). Twelve healt
  • PMID 25700630
  • Fed and fasted chicks from lines divergently selected for low or high body weight have differential hypothalamic appetite-associated factor mRNA expression profiles.
  • Yi J1, Gilbert ER1, Siegel PB1, Cline MA2.
  • Behavioural brain research.Behav Brain Res.2015 Jun 1;286:58-63. doi: 10.1016/j.bbr.2015.02.008. Epub 2015 Feb 10.
  • We have demonstrated that chicken lines which have undergone intense divergent selection for either low (LWS) or high (HWS) body weight (anorexic and obese containing, respectively) have differential food intake threshold responses to a range of intracerebroventricular injected neurotransmitters. Th
  • PMID 25677648


  • Ghrelin-induced hypophagia is mediated by the β₂ adrenergic receptor in chicken
  • Zendehdel Morteza,Hassanpour Shahin
  • The journal of physiological sciences 64(5), 383-391, 2014-09
  • NAID 40020178499
  • グレリン,グルカゴン様ペプチド1と迷走神経 (第5土曜特集 肥満の医学 : 臨床と研究の最先端) -- (中枢と末梢の臓器間ネットワーク)
  • 十枝内 厚次,ワイズ T. M. ザベット,中里 雅光
  • 医学のあゆみ 250(9), 773-777, 2014-08-30
  • NAID 40020171511
  • 迷走神経を介した消化管ペプチドによる摂食調節
  • 十枝内 厚次,Waise TM Zaved,中里 雅光
  • 内分泌・糖尿病・代謝内科 39(1), 62-68, 2014-07
  • NAID 40020175887
  • 神経内分泌学の歴史と現状 (特集 拡がりゆく神経内分泌学の現状と展望)
  • 山口 秀樹,中里 雅光,寒川 賢治
  • 内分泌・糖尿病・代謝内科 39(1), 2-9, 2014-07
  • NAID 40020175681



Elusive Ligand Ghrelin Could Have Numerous Preproghrelin mit Ghrelin (grün) nach PDB ghrelinStructural Model of GhrelinGhrelin?leptin and ghrelinWhen ghrelin increases to increase Ghrelin

拡張検索ghrelin receptor



anterior pituitary hormone


GOO. chapter 55

名称 構造 分泌細胞 下垂体前葉細胞
染色性 サブユニット 残基数
成長ホルモン GH ペプチド somatotroph 40-50% 好酸性   1 191 22  
プロラクチン PRL mammotroph 10-25% 好酸性   1 199 23  
副腎皮質刺激ホルモン ACTH corticotroph 0.1 好塩基性 嫌色素性 1 39 4.5 POMC由来
甲状腺刺激ホルモン TSH 糖タンパク thyrotroph 0.05 好塩基性   2 α: 92, β:118 28 αサブユニットは共通
卵胞刺激ホルモン FSH gonadotroph 10-15% 好塩基性   2 α: 92, β:111 32.6
黄体形成ホルモン LH 好塩基性   2 α: 92, β:121 29.4


Table 333-1 Anterior Pituitary Hormone Expression and Regulation
Cell corticotrope somatotrope lactotrope thyrotrope gonadotrope
Tissue-specific transcription factor T-Pit Prop-1, Pit-1 Prop-1, Pit-1 Prop-1, Pit-1, TEF SF-1, DAX-1
Fetal appearance 6 weeks 8 weeks 12 weeks 12 weeks 12 weeks
Chromosomal locus 2p 17q 6 -6q; -1p -11p; -19q
Protein ポリペプチド 糖タンパク
Amino acids 266 (ACTH 1–39) 191 199 211 210 204
Stimulators CRH, AVP, gp-130 cytokines GHRH, ghrelin, bromocriptine(1) estrogen, TRH, VIP TRH GnRH, activins, estrogen
Inhibitors glucocorticoids somatostatin, IGF-I dopamine T3, T4, dopamine, somatostatin, glucocorticoids sex steroids, inhibin
Target gland adrenal liver, other tissues breast, other tissues thyroid ovary, testis
Trophic effect steroid production IGF-I production, growth induction, insulin antagonism milk production T4 synthesis and secretion sex steroid production, follicle growth, germ cell maturation





ghrelin receptor」


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