geranylgeranyl pyrophosphate synthase

出典: meddic


geranylgeranyl-diphosphate geranylgeranyltransferase

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  • Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.
  • Yang J, Mou Y, Wu T, Ye Y, Jiang JC, Zhao CZ, Zhu HH, Du CQ, Zhou L, Hu SJ.SourceInstitute of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No.79, Qing-Chun Road, Hangzhou 310003, China.
  • Cardiovascular research.Cardiovasc Res.2013 Mar 1;97(3):490-9. doi: 10.1093/cvr/cvs347. Epub 2012 Nov 24.
  • AIMS: Farnesyl pyrophosphate synthase (FPPS) is a key enzyme in the mevalonate pathway. In our previous study, we found that inhibition of FPPS attenuates cardiac hypertrophy in spontaneously hypertensive rats (SHRs) and prevents angiotensin (Ang) II-induced hypertrophy in cardiomyocytes. Here, we f
  • PMID 23180723
  • Functional characterization of three Coffea arabica L. monoterpene synthases: Insights into the enzymatic machinery of coffee aroma.
  • Del Terra L, Lonzarich V, Asquini E, Navarini L, Graziosi G, Suggi Liverani F, Pallavicini A.Sourceillycaffè SpA, via Flavia 110, 34147 Trieste, Italy. Electronic address:
  • Phytochemistry.Phytochemistry.2013 Feb 8. pii: S0031-9422(13)00027-7. doi: 10.1016/j.phytochem.2013.01.005. [Epub ahead of print]
  • The chemical composition of the coffee beverage is extremely complex, being made up of hundreds of volatile and non-volatile compounds, many of which are generated in the thermal reactions that occur during the roasting process. However, in the raw coffee bean there are also compounds that survive r
  • PMID 23398891
  • Molecular cloning and characterization of GbDXS and GbGGPPS gene promoters from Ginkgo biloba.
  • Xu F, Huang XH, Li LL, Deng G, Cheng H, Rong XF, Li JB, Cheng SY.SourceCollege of Horticulture and Gardening, Yangtze University, Jingzhou, Hubei, China.
  • Genetics and molecular research : GMR.Genet Mol Res.2013 Feb 4;12(1):293-301. doi: 10.4238/2013.February.4.3.
  • Ginkgolides are key pharmaceutical components in Ginkgo biloba leaves. 1-Deoxy-D-xylulose-5-phosphate synthase (GbDXS) and geranylgeranyl pyrophosphate (GbGGPPS) genes are critical genes involved in ginkgolide biosynthesis. In this study, the promoters of GbDXS and GGPPS, with 676 and 570 bp in
  • PMID 23408416


  • Pitavastatin Decreases Tau levels Via the Inactivation of Rho/ROCK
  • HAMANO Tadanori,YEN Shu-Hui,GENDRON Tania,KO Li-wen,KURIYAMA Masaru
  • Neurobiology of Aging 33, 2011-11
  • … The decrease caused by pitavastatin is reversed by the addition of mevalonate, or geranylgeranyl pyrophosphate. … The maturation of small G proteins, including RhoA was disrupted by pitavastatin, as was the activity of glycogen synthase kinase 3β (GSK3β), a major tau kinase. … Rho kinase inhibitor also inactivated glycogen synthase kinase 3β. …
  • NAID 120003593722
  • 骨芽細胞増殖,分化におけるGGPP-RhoカスケードとGGPP synthaseの役割 (第7回日本骨粗鬆症学会 一般演題Highlight)
  • 吉田 知彦
  • オステオポローシスジャパン 14(2), 260-263, 2006
  • NAID 40007315193
  • The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding


Identification Name: Geranylgeranyl pyrophosphate synthase Synonyms GGPP synthase GGPPSase BET2 suppressor protein 1 Geranylgeranyl diphosphate synthase Dimethylallyltranstransferase Geranyltranstransferase
Geranylgeranyl pyrophosphate synthase, chloroplastic; GGPP synthase; GGPS; EC 2.5.1.-; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; EC; Farnesyl diphosphate synthase; EC; ...



リンク元ゲラニルゲラニルピロリン酸合成酵素」「geranylgeranyl-diphosphate geranylgeranyltransferase」「ゲラニルゲラニルピロリン酸シンターゼ



geranylgeranyl pyrophosphate synthase

geranylgeranyl-diphosphate geranylgeranyltransferase」



geranylgeranyl pyrophosphate synthase



geranylgeranyl pyrophosphate synthase


  [★] ピロリン酸二リン酸

bisphosphatediphosphatediphosphoric acidPPi

WordNet   license wordnet

「a salt or ester of pyrophosphoric acid」



  • n.