frontotemporal dementia

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/04/08 14:46:04」(JST)

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  • TREM2 mutations are rare in a French cohort of patients with frontotemporal dementia.
  • Lattante S, Le Ber I, Camuzat A, Dayan S, Godard C, Van Bortel I, De Septenville A, Ciura S, Brice A, Kabashi E; French Research Network on FTD and FTD-ALS.SourceCentre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, INSERM UMR_S975, CNRS UMR7225, Université Pierre et Marie Curie-Paris 6, Hôpital Pitié-Salpêtrière, Paris, France.
  • Neurobiology of aging.Neurobiol Aging.2013 Oct;34(10):2443.e1-2. doi: 10.1016/j.neurobiolaging.2013.04.030. Epub 2013 Jun 4.
  • Homozygous mutations in TREM2 have been recently identified by exome sequencing in families presenting with frontotemporal dementia (FTD)-like phenotype. No study has evaluated the exact frequency of TREM2 mutations in cohorts of FTD patients so far. We sequenced TREM2 in 175 patients with pure FTD,
  • PMID 23759145
  • Transgenic models of Alzheimer's disease: Better utilization of existing models through viral transgenesis.
  • Platt TL, Reeves VL, Murphy MP.SourceDepartment of Cellular and Molecular Biochemistry, University of Kentucky, 741 S. Limestone Street, Lexington, KY 40536, USA; Sanders Brown Center on Aging, University of Kentucky, 800 S. Limestone Street, Lexington, KY 40536-0230, USA.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2013 Sep;1832(9):1437-48. doi: 10.1016/j.bbadis.2013.04.017. Epub 2013 Apr 22.
  • Animal models have been used for decades in the Alzheimer's disease (AD) research field and have been crucial for the advancement of our understanding of the disease. Most models are based on familial AD mutations of genes involved in the amyloidogenic process, such as the amyloid precursor protein
  • PMID 23619198
  • Biosensing MAPs as "roadblocks": kinesin-based functional analysis of tau protein isoforms and mutants using suspended microtubules (sMTs).
  • Tarhan MC, Orazov Y, Yokokawa R, Karsten SL, Fujita H.SourceCenter for International Research on Micronano Mechatronics, Institute of Industrial Science, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo, 153-8505, Japan.
  • Lab on a chip.Lab Chip.2013 Aug 21;13(16):3217-24. doi: 10.1039/c3lc50151e. Epub 2013 Jun 18.
  • The concept of a reconstructed microtubule kinesin-based transport system was originally introduced for studies of underlying biophysical mechanisms of intracellular transport and its potential applications in bioengineering at micro- and nanoscale levels. However, several technically challenging sh
  • PMID 23778963


  • 認知症の画像診断
  • 小出 百合,林 俊宏,岩田 淳
  • Japanese Journal of Neurosurgery 22(7), 525-531, 2013
  •  わが国では65歳以上の認知症有病率が14%程度と推定されており, 高齢化に伴って今後も増え続けるといわれる. 近年の画像診断技術の発展は目覚ましく, アルツハイマー病をはじめとする変性性認知症の診断に大きく貢献している. 構造画像では, 以前は非変性性認知症の除外診断が主目的であったが, 最近では, アルツハイマー病での海馬や嗅内野の萎縮など, 積極的に認知症を鑑別するようになってきている. ま …
  • NAID 130003379639
  • Changes in the Clinical Features of Amyotrophic Lateral Sclerosis in Rural Japan
  • Furuta Natsumi,Makioka Kouki,Fujita Yukio,Okamoto Koichi
  • Internal Medicine 52(15), 1691-1696, 2013
  • … The percentage of ALS patients with dementia increased from 0% (1978-82) to 20.2% (2008-12). … Conclusion Our findings demonstrate that, among patients with sporadic ALS, the age at disease onset, the proportion of patients with disease onset at 70 years of age or higher, the proportion of patients with dementia and the proportion of patients with bulbar onset ALS have increased significantly over the past 35 years. …
  • NAID 130003365732
  • 前頭側頭型認知症の特徴を活かした構造化プログラムの有用性に関する研究
  • 竹内 陽子,長谷川 雅美
  • 日本看護研究学会雑誌 = Journal of Japanese Society of Nursing Research 35(4), 13-24, 2012-09-00
  • NAID 40019462598


Frontotemporal dementia (FTD) is the clinical syndrome caused by degeneration of the frontal lobe of the brain. The degeneration may extend to the temporal lobe . FTD is the clinical manifestation of frontotemporal lobar degeneration, and the ...
This factsheet provides some general information about one of the rarer forms of dementia: fronto-temporal dementia. It explains who is likely to be affected, what symptoms they may experience, how it is diagnosed, and what can be done to ...



拡張検索frontotemporal dementia and parkinsonism linked to chromosome 17」「familial frontotemporal dementia



frontotemporal dementia FTD

  • 初期には近時記憶の障害は目立たない (PSY.334)
  • 側頭葉および前頭葉の葉状萎縮。 (PSY.334)
  • 前頭葉優位型:周囲の状況に無関心で自らの慣習的行動に固執する常同行動が目立つ
  • 左側頭葉優位型:言語的意味情報を貯蔵する部位の機能が脱落するために、語彙項目そのものが次第に減少して、音読や復唱が可能な単語の意味が分からない語義失語が特徴的に現れる
  • 右側頭葉優位型:非言語的意味情報が同様に脱落するため、親しい人物の顔を見ても声を聞いても誰だか分からない人物同定の障害、ものを見てもさわっても分からない物品同定の障害が現れる。



frontotemporal lobar degeneration
  • 広義のピック病
  • 前頭葉・側頭葉が神経細胞脱落によって萎縮する疾患群。Pick小体の有無を問わない。






frontotemporal dementia

frontotemporal dementia and parkinsonism linked to chromosome 17」




familial frontotemporal dementia」

  [★] 家族性前頭側頭型認知症


  [★] 認知症

WordNet   license wordnet

「mental deterioration of organic or functional origin」

PrepTutorEJDIC   license prepejdic




  • v.
  • 痴呆になる、発狂する