出典: meddic

  • n.

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「violent and bitter exasperation; "his foolishness was followed by an exacerbation of their quarrel"」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/07/20 14:54:28」(JST)

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  • Patterned changes in urge ratings with tic suppression in youth with chronic tic disorders.
  • Brabson LA1, Brown JL1, Capriotti MR2, Ramanujam K3, Himle MB3, Nicotra CM1, Ostrander R1, Kelly LM1, Grados MA1, Walkup JT1, Perry-Parrish C1, Reynolds EK1, Hankinson JC1, Specht MW4.
  • Journal of behavior therapy and experimental psychiatry.J Behav Ther Exp Psychiatry.2016 Mar;50:162-70. doi: 10.1016/j.jbtep.2015.07.004. Epub 2015 Jul 13.
  • BACKGROUND: Premonitory urges are central to emerging behavioral models of chronic tic disorders (CTD). Urge reduction has been proposed as a behavioral explanation for tic maintenance and exacerbation as well as the efficacy of behavioral treatments. Prior investigations have produced inconsistent
  • PMID 26255052
  • Pediatric Respiratory Emergencies.
  • Richards AM1.
  • Emergency medicine clinics of North America.Emerg Med Clin North Am.2016 Feb;34(1):77-96. doi: 10.1016/j.emc.2015.08.006.
  • Respiratory emergencies are 1 of the most common reasons parents seek evaluation for the their children in the emergency department (ED) each year, and respiratory failure is the most common cause of cardiopulmonary arrest in pediatric patients. Whereas many respiratory illnesses are mild and self-l
  • PMID 26614243
  • Management of Acute Exacerbation of Asthma and Chronic Obstructive Pulmonary Disease in the Emergency Department.
  • Suau SJ1, DeBlieux PM2.
  • Emergency medicine clinics of North America.Emerg Med Clin North Am.2016 Feb;34(1):15-37. doi: 10.1016/j.emc.2015.08.002.
  • Acute asthma and chronic obstructive pulmonary disease (COPD) exacerbations are the most common respiratory diseases requiring emergent medical evaluation and treatment. Asthma and COPD are chronic, debilitating disease processes that have been differentiated traditionally by the presence or absence
  • PMID 26614239
  • Infections and mixed infections with the selected species of Borrelia burgdorferi sensu lato complex in Ixodes ricinus ticks collected in eastern Poland: a significant increase in the course of 5 years.
  • Wójcik-Fatla A1, Zając V2, Sawczyn A2, Sroka J2,3, Cisak E2, Dutkiewicz J2.
  • Experimental & applied acarology.Exp Appl Acarol.2016 Feb;68(2):197-212. doi: 10.1007/s10493-015-9990-4. Epub 2015 Nov 21.
  • In the years 2008-2009 and 2013-2014, 1620 and 1500 questing Ixodes ricinus ticks, respectively, were examined on the territory of the Lublin province (eastern Poland). The presence of three pathogenic species causing Lyme disease was investigated: Borrelia burgdorferi sensu stricto, B. afzelii and
  • PMID 26590929


  • 抗IL-5療法 (特集 アレルギー性疾患における新規治療戦略)
  • 中込 一之,永田 真
  • 臨床免疫・アレルギー科 = Clinical immunology & allergology 64(2), 154-159, 2015-08
  • NAID 40020563147
  • Pathological and radiological correlation in an autopsy case of combined pulmonary fibrosis and emphysema
  • Karata Hiroki,Tanaka Tomonori,Egashira Ryoko,Tabata Kazuhiro,Otani Kyoko,Hayashi Ryuji,Hori Takashi,Fukuoka Junya
  • International Journal of Chronic Obstructive Pulmonary Disease 10(1), 1299-1303, 2015-07-08
  • … The patient eventually developed acute exacerbation of background interstitial pneumonia. …
  • NAID 120005627354
  • Surgical resection of a pulmonary artery pseudoaneurysm after middle lobectomy: Report of a case
  • Miyazaki Takuro,Yamasaki Naoya,Tsuchiya Tomoshi,Matsumoto Keitaro,Shimoyama Koichiro,Taniguchi Daisuke,Kinoshita Naoe,Nagayasu Takeshi
  • Acta medica Nagasakiensia 60(1), 25-27, 2015-07
  • … The patient's postoperative course following repeat thoracotomy was complicated, including exacerbation of interstitial pneumonia and tracheostomy. …
  • NAID 120005627333
  • 増悪 (特集 COPD(慢性閉塞性肺疾患) : 内科医の診断と治療の向上を目指して) -- (COPD病態・治療)
  • 橋本 修
  • 日本内科学会雑誌 104(6), 1098-1107, 2015-06-10
  • NAID 40020510646




リンク元100Cases 14」「deteriorate」「acerb」「exaggerate」「aggravation

100Cases 14」


☆case14 複視
diplopia n. 複視
筋力低下筋無力筋脱力 muscle weakness, muscular weakness
vt. sinkのpp.
3,4-ジアミノピリジン 3,4-diaminopyridine 3,4-DAP K+チャネル阻害薬;ランバートイートン筋無力治療
43-year-old woman
cheif complaint: diplopia
present history: diplopia and holding her head up ; more marked in the evenings, for the last 3 months. difficulty of chewing. voice has become quieter. weight loss (3kg / 6months). non-smoker. drinks about 15 units/week. no regular medication.
past history: no significant previous medical illnesses.
family history: lives with her husband and three children.
診察 examination
looks well.
organ systems: normal; cardiovascular, respiratory, and abdominal systems.
muscle power; grossly normal. decrease after testing a movement repetitively.
motor function: normal; tone, coordination, reflexes and sensation.
bilateral ptosis. exacerbated by prolonged upward gaze
eye: normal; pupillary reflexes, eye movements, and funduscopy
diagnosis: myathenia gravis
differential diagnoses:
上位and/or下位運動ニューロン motor neurone disease 運動ニューロン疾患線維束性攣縮進行例では筋力低下
muscular dystrophy 筋ジストロフィー:ある種の筋肉選択的筋力低下する。家族歴がある。
dystrophia myotonica 強直性筋ジストロフィー咬筋側頭筋胸鎖乳突筋筋萎縮四肢遠位端の筋萎縮顔貌特徴的(前頭部脱毛、無表情、窪んだ頬)。家族歴ある。筋電図診断有用(急降下爆撃音)。
polymyositis 多発筋炎普通皮疹関節痛出現CK上昇筋生検診断有用
myopathy ミオパチー:甲状腺中毒性ミオパチー甲状腺機能低下症によるミオパチークッシング症候群によるミオパチーアルコール性のミオパチー
神経筋接合部non-metastatic associations of malignancy (paraneoplastic syndrome(傍腫瘍性症候群 = 腫瘍随伴症候群)のこと):胸腺腫症例の10%に重症筋無力症がみられる。ランバートイートン筋無力症候群小細胞癌関連がある。
Treatment with penicillamine (used for scleroderma or rheumatoid arthritis) may result in true autoimmune MG, but the weakness is usually mild, and recovery occurs within weeks or months after discontinuing its use.
Aminoglycoside antibiotics or procainamide can cause exacerbation of weakness in myasthenic patients; very large doses can cause neuromuscular weakness in normal individuals.
HIM = Harrison's Principles of Internal Medicine 17th Edition
CASES = 100 Cases in Clinical Medicine Second edition
IMD = 内科診断学第2版



(de-(悪化)+ -terior(より悪く) + -ate )より一層悪くする
  • vi.
  • 悪くなる、(~に)悪化する(into)。(道徳などが)低下する、堕落する。衰える
As the disease progresses and speech deteriorates communication may be helped by using computers.(病気が悪化し、発話が悪くなったとき、コンピュータの使用で会話は補助されうる)
  • vt.
  • (価値・品質など)を悪くする、悪化させる。~を悪化させる
aggravate, aggravation, alter, alteration, deterioration, exacerbate, exacerbation, exaggerate, exaggeration, worsen

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「become worse or disintegrate; "His mind deteriorated"」

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「…‘を'悪化させる;…‘の'品質などを低下させる / 〈人格・品質・価値などが〉悪化する,低下する」



  • adj.
  • 酸っぱい、渋い、苦い、渋い
  • (ことば、態度、気質などが)とげとげしい、辛辣な
(vt.)exacerbate, (n.)exacerbation

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「sour or bitter in taste」
acerbic, astringent

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「(味が)すっぱい(sour),苦い,渋い / (ことば・態度が)厳しい,しんらつな」

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「harsh or corrosive in tone; "an acerbic tone piercing otherwise flowery prose"; "a barrage of acid comments"; "her acrid remarks make her many enemies"; "bitter words"; "blistering criticism"; "caustic jokes about political assassination, talk-show hosts and medical ethics"; "a sulfurous denunciation"; "a vitriolic critique"」
acerbic, acid, acrid, bitter, blistering, caustic, sulfurous, sulphurous, virulent, vitriolic



  • vt.
  • 大げさに言う、誇張する。誇大に考える、過大視する。際だたせる
  • (病気、状態を)悪化させる、激化させる。(器官を)肥大させる
Pulsus paradoxus may also be manifest by other conditions in which inspiration is exaggerated, including severe asthma and chronic obstructive airway disease.
Exaggerated perifollicular neovascularization with some of the new blood vessels exhibiting increased permeability.(uptodate)()
  • vi.
  • 誇張した言い方をする

(adj.)exaggerated 誇大な、過度の。(動)異常に大きな、肥大した
aggravate, aggravation, deteriorate, deterioration, exacerbate, exacerbation, exaggeration, worsen

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「…‘を'『誇張する』,大げさに言う(考える) / 誇張する,大げさに言う」



  • n.
  • 悪化、重大化。悪化させるもの/事柄。(怒り・いらだち・不快感・反感を誘う)挑発(行為)

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「action that makes a problem or a disease (or its symptoms) worse; "the aggravation of her condition resulted from lack of care"」

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「unfriendly behavior that causes anger or resentment」
irritation, provocation

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「an exasperated feeling of annoyance」

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「悪化,深刻化 / 〈C〉《話》腹立ちの原因」