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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/12/15 17:34:11」(JST)

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  • Comparison of adverse events and efficacy between gefitinib and erlotinib in patients with non-small-cell lung cancer: a retrospective analysis.
  • Yoshida T, Yamada K, Azuma K, Kawahara A, Abe H, Hattori S, Yamashita F, Zaizen Y, Kage M, Hoshino T.SourceDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka, 830-0011, Japan.
  • Medical oncology (Northwood, London, England).Med Oncol.2013 Mar;30(1):349. doi: 10.1007/s12032-012-0349-y. Epub 2012 Dec 22.
  • Previous studies have demonstrated that both gefitinib and erlotinib are markedly effective for the treatment of non-small-cell lung cancer (NSCLC) with somatic activating mutations of the epidermal growth factor receptor gene (EGFR-mt). These agents are considered to act on EGFR through the same me
  • PMID 23263831
  • Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives containing benzodioxole as potential anticancer agents.
  • Wang HH, Qiu KM, Cui HE, Yang YS, Yin-Luo, Xing M, Qiu XY, Bai LF, Zhu HL.SourceState Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.
  • Bioorganic & medicinal chemistry.Bioorg Med Chem.2013 Jan 15;21(2):448-55. doi: 10.1016/j.bmc.2012.11.020. Epub 2012 Nov 24.
  • A series of novel thiazolyl-pyrazoline derivatives containing benzodioxole (C1-C20) have been designed and synthesized. Among of the synthesized compounds, 2-(5-(benzo[d][1,3]dioxol-5-yl)-3-(4-bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-(4-bromophenyl)thiazole (C6) displayed the most potent inhibito
  • PMID 23245802
  • Overcoming erlotinib resistance with tailored treatment regimen in patient-derived xenografts from naïve Asian NSCLC patients.
  • Yang M, Shan B, Li Q, Song X, Cai J, Deng J, Zhang L, Du Z, Lu J, Chen T, Wery JP, Chen Y, Li Q.SourceCrown Bioscience, Inc., 3375 Scott Blvd, suite 108, Santa Clara, CA 95054, USA.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2013 Jan 15;132(2):E74-84. doi: 10.1002/ijc.27813. Epub 2012 Oct 3.
  • Overall benefits of EGFR-TKIs are limited because these treatments are largely only for adenocarcinoma (ADC) with EGFR activating mutation. The treatments also usually lead to development of resistances. We have established a panel of patient-derived xenografts (PDXs) from treatment naïve Asian NSC
  • PMID 22948846



公的会議で取り上げられた国内未承認薬の情報【専門家向け】 厚生労働省の未承認薬使用問題検討会議/医療上の ... 国内販売名:タルセバ錠25mg、100mg 海外販売名:Tarceva/一般名:erlotinib/治験成分記号:R1415 国内承認 ...
Erlotinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: diarrhea loss of appetite nausea vomiting heartburn gas constipation stomach pain mouth sores weight loss






  • 受容体のリガンド結合部を標的とした小分子化合物。


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