ergotamine

出典: meddic

エルゴタミン

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「an alkaloid derived from ergot that is less toxic than ergot; causes constriction of blood vessels and is used to treat migraine」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/11/20 16:23:23」(JST)

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英文文献

  • Dietary exposure to ergot alkaloids decreases contractility of bovine mesenteric vasculature.
  • Egert AM1, Kim DH, Schrick FN, Harmon DL, Klotz JL.Author information 1Department of Animal and Food Sciences, University of Kentucky, Lexington 40546.AbstractErgot alkaloids are hypothesized to cause vasoconstriction in the midgut, and prior exposure may affect the vasoactivity of these compounds. The objectives of this study were to profile vasoactivity of ergot alkaloids in bovine mesenteric artery (MA) and vein (MV) and determine if previous exposure to endophyte-infected tall fescue seed affected vasoactivity of ergocryptine (ERP), ergotamine (ERT), ergocristine (ERS), ergocornine (ERO), ergonovine (ERN), lysergic acid (LSA), ergovaline-containing tall fescue seed extract (EXT), and 5-hydroxytryptamine (5HT; serotonin). Ruminally cannulated Angus steers (n = 12; BW = 547 ± 31 kg) were paired by weight and randomly assigned to 6 blocks. Steers were ruminally dosed daily with 1 kg of either endophyte-infected (E+; 4.45 mg ergovaline/kg DM) or endophyte-free (E-; 0 mg ergovaline/kg DM) tall fescue seed for 21 d before slaughter. Branches of MA and MV supporting the cranial portion of the ileum were collected after slaughter on d 22, placed in a modified Krebs-Henseleit buffer on ice, cleaned, sectioned, and mounted in a multimyograph chamber. Contractile response was normalized to a maximum KCl response. Inner diameter (P = 0.04) and outer diameter (P = 0.02) of MA were smaller for E+ steers than E- steers. Maximum contractile responses to 120 mM KCl were not different between seed treatments in MA (P = 0.33; E-: 2.67 ± 0.43 g; E+: 3.33 ± 0.43 g) or MV (P = 0.26; E-: 2.01 ± 0.18 g; E+: 1.81 ± 0.18 g). Steers receiving E+ had a smaller (P < 0.01) MA contractile response than E- steers to ERP, ERT, ERS, ERO, ERN, EXT, and 5HT. Steers receiving E+ had a smaller (P < 0.05) MV contractile response than E- steers to ERP, ERT, ERS, ERN, EXT, and 5HT. Lysergic acid failed to induce a contractile response in MA and MV. The contractile response in MA and MV of E- steers produced by 5HT was very large. The EXT was the most potent (P < 0.05) agonist in MV and MA of E+ steers. These data showed that ergot alkaloids were vasoactive in the bovine midgut, and steers exposed to E+ had diminished contractility to some ergot alkaloids in small intestinal vasculature. The findings of this study suggest that dietary exposure to ergot alkaloids has the potential to alter nutrient absorption from the midgut by decreasing blood flow to and from the midgut due to vasoconstriction.
  • Journal of animal science.J Anim Sci.2014 Apr;92(4):1768-79. doi: 10.2527/jas.2013-7141. Epub 2014 Feb 3.
  • Ergot alkaloids are hypothesized to cause vasoconstriction in the midgut, and prior exposure may affect the vasoactivity of these compounds. The objectives of this study were to profile vasoactivity of ergot alkaloids in bovine mesenteric artery (MA) and vein (MV) and determine if previous exposure
  • PMID 24492572
  • Evaluation of the valvular and biventricular functions in Parkinson patients using ergotamine-derived dopamine agonist: an observational study.
  • Ozer N1, Yorgun H, Canpolat U, Elibol B.Author information 1Departments of Cardiology and *Neurology, Faculty of Medicine, Hacettepe University; Ankara-Turkey. dru_canpolat@yahoo.com.AbstractOBJECTIVE: In this study, we aimed to evaluate the impact of cabergoline use in patients with Parkinson's disease on valvular and biventricular functions.
  • Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology.Anadolu Kardiyol Derg.2014 Mar;14(2):121-7. doi: 10.5152/akd.2014.4834. Epub 2014 Jan 14.
  • OBJECTIVE: In this study, we aimed to evaluate the impact of cabergoline use in patients with Parkinson's disease on valvular and biventricular functions.METHODS: In this observational cohort study, patients with Parkinson disease were divided into 2 groups as 34 patients (41.2% female, age; 57.4±1
  • PMID 24449623
  • Bovine lateral saphenous veins exposed to ergopeptine alkaloids do not relax.
  • Pesqueira A1, Harmon DL, Branco AF, Klotz JL.Author information 1Department of Animal and Food Sciences, University of Kentucky, Lexington 40546.AbstractThe ergot alkaloid ergovaline has demonstrated a persistent and sustained contractile response in several different vascular models. It was hypothesized that different alkaloids isolated from tall fescue (Lolium arundinaceum) will contribute to this contractile response differently. The objective was to compare contractile-response patterns of single additions of the ergoline alkaloids lysergic acid, lysergol, and ergonovine and the ergopeptine alkaloids ergotamine, ergocristine, ergocryptine, ergocornine, and ergovaline (provided as tall fescue seed extract). Lateral saphenous veins were collected from 6 Holstein steers (BW = 397 ± 28 kg) immediately after slaughter, sliced into cross-sections, and suspended in myograph chambers containing oxygenated Krebs-Henseleit buffer (95% O2/5% CO2; pH = 7.4; 37°C). Treatments were added at 0 min and buffer was replaced in 15-min intervals for a 120-min incubation. In addition to maximum tension and time to reach maximum tension, percent relaxation and rate of relaxation were determined following maximum tension for each treatment. All compounds tested produced significant contractile responses (P < 0.05). All ergoline alkaloids reached maximum response in less time (P < 0.05) than the remaining compounds and began to relax immediately after first buffer change. Lysergic acid had the greatest (P < 0.05) percent relaxation and ergonovine had the greatest (P < 0.05) rate of relaxation. The ergopeptine alkaloids ergovaline, ergotamine, ergocristine, ergocryptine, and ergocornine had slower developing contractile responses with a longer (P < 0.05) interval until maximum tension was achieved compared to the ergoline alkaloids. Maximal responses to all the ergopeptine alkaloids, however, all persisted for the 120-min duration with negligible relaxation occurring. The different classes of alkaloids differed greatly in the type of contractile response generated in the lateral saphenous vein. Persistence of contractile response is thought to be the primary contributing factor to the vasoconstriction observed in animals demonstrating signs of fescue toxicosis, where different ergot alkaloids can contribute differently.
  • Journal of animal science.J Anim Sci.2014 Mar;92(3):1213-8. doi: 10.2527/jas.2013-7142. Epub 2014 Feb 3.
  • The ergot alkaloid ergovaline has demonstrated a persistent and sustained contractile response in several different vascular models. It was hypothesized that different alkaloids isolated from tall fescue (Lolium arundinaceum) will contribute to this contractile response differently. The objective wa
  • PMID 24492541

和文文献

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  • 自律神経 = The Autonomic nervous system 46(6), 544-550, 2009-12-15
  • NAID 10026904695
  • 身体感覚の気づきの回復過程にて前兆を認めるようになった難治性片頭痛の一症例
  • 蓮尾 英明,神原 憲治,山下 直人,本多 啓介,楠 裕明,福永 幹彦,中井 吉英
  • バイオフィードバック研究 36(1), 63-68, 2009-04-25
  • 症例は30歳代女性.主訴は頭痛.交通外傷後からの前兆のない片頭痛(トリプタン無反応性、アロディニア併存)が病態の中心になっていた.当初,感情の気づきや表現が困難な状態で,身体感覚の気づきも低下していた.そこで,客観的な生理指標の評価として精神生理学的ストレスプロファイル(Psychophysiological Stress Profile,以下PSPと略す)を施行した.その結果,ストレス負荷を契機 …
  • NAID 110007227167
  • 薬物乱用頭痛への心身医学的アプローチ
  • 花岡 啓子,花岡 芳雄,村上 正人 [他],桂 戴作
  • 心身医学 47(5), 317-324, 2007-05-01
  • 片頭痛などの頭痛に急性期治療薬を連用することによって引き起こされる薬物乱用頭痛の治療では,乱用薬物の中止が不可欠であるが,離脱1年目の再発率は38%,4年までは42%との報告があり再発防止が大きな課題である.今回,薬物乱用頭痛患者10名に生活指導や薬物療法などの身体医学的治療のみならず心身医学的アプローチを行ったので,その効果を報告し,治療戦略について考察する.心身医学療法として受容,支持,保証, …
  • NAID 110006278112

関連リンク

古くから片頭痛の治療薬として使われてきたエルゴタミン製剤は、現在ではトリプタン系薬剤を服用できない片頭痛患者さんなどに限定的に使用されています。
酒石酸エルゴタミンergotamine Part 1 ライ麦に生える麦角からとれた ergotは蹴爪の意味 麦角中毒 壊死型 痙攣型 急性中毒型 「悪魔の蹴爪」として恐れられた 麦角は薬剤の宝庫 抗パーキンソン病薬 子宮収縮剤 LSD オウム真理教は ...

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ergotamine
ergotaminum
酒石酸エルゴタミン ergotamine tartrate
パンエルゴットヒポラールクリアミンジヒデルゴット。Cafatine, Cafergot
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dihydroergotamine mesilate」

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dihydroergotamine


ergotamine tartrate」

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