enterochromaffin-like cells

腸クロム親和性細胞様細胞 ECL cells

WordNet

1. want to have; "Id like a beer now!"
2. a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
3. a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
4. equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
5. resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
6. be fond of; "I like my nephews"
7. feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
8. find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
9. small room in which a monk or nun lives (同)cubicle
10. a device that delivers an electric current as the result of a chemical reaction (同)electric cell
11. a room where a prisoner is kept (同)jail cell, prison cell
12. (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
13. any small compartment; "the cells of a honeycomb"
14. a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
15. a feeling of pleasure and enjoyment; "Ive always had a liking for reading"; "she developed a liking for gin"
16. found pleasant or attractive; often used as a combining form; "a well-liked teacher"
17. Chinese distance measure; approximately 0.5 kilometers

PrepTutorEJDIC

1. …‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
2. (外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
3. (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
4. (…の)『好み』,趣味《+『for』(『to』)+『名』》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/22 17:26:00」(JST)

wiki en

[Wiki en表示]

Not to be confused with Enterochromaffin cell.

Enterochromaffin-like cell
Control of stomach acid secretions. (ECL-cell at top center.)
Details
Identifiers
Latin	endocrinocytus ECL
MeSH	Enterochromaffin-like+Cells
Code	TH H3.04.02.0.00030
Anatomical terminology [edit on Wikidata]

Enterochromaffin-like cells or ECL cells are a type of neuroendocrine cells found in the gastric glands of the gastric mucosa beneath the epithelium, in particular in the vicinity of parietal cells, that aid in the production of gastric acid via the release of histamine. They are also considered a type of enteroendocrine cell.

Function

Histamine

ECL cells synthesize and secrete histamine. These cells are stimulated by the hormones gastrin and pituitary adenylyl cyclase-activating peptide. G cells are stimulated by vagal stimulation through the neurotransmitter gastrin-releasing peptide; this causes the G cells to secrete gastrin, which in turn stimulates ECL cells to release histamine. Note that this circuit is not activated by acetylcholine, which is of particular importance because the administration of atropine will not block the vagal stimulation of the G cells, as ACh is not the neurotransmitter for these cells.

However, ECL cells are activated directly by ACh on M1 receptors from direct vagal innervation leading to histamine release. This pathway will be inhibited by atropine.

Gastrin is transferred from a specific type of G cell in the gastric epithelium to the ECL cells by blood. Histamine and gastrin act synergistically as the most important stimulators of hydrochloric acid secretion from parietal cells and stimulators of secretion of pepsinogen from chief cells. The most important inhibitor of the ECL cell is somatostatin from oxyntic D cells.

Enterochromaffin-like cells also produce pancreastatin and probably other peptide hormones and growth factors.

Pathology

A prolonged stimulation of these cells causes their hyperplasia. This is especially important in gastrinoma (the tumors in which there is an excessive secretion of gastrin), as this is one of the factors contributing to Zollinger–Ellison's syndrome. It was once believed that tumors of ECL origin form after a prolonged inhibition of gastric acid secretion, however there is no data to support this conclusion and proton pump inhibitors are not thought to contribute to gastric cancer.

Name

The name is derived from their location in the enteric system and their chromaffin-like staining pattern in histologic sections, which is characterized by silver staining.

References

See also

• Enterochromaffin cell
• Chromaffin cell

UpToDate Contents

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• 1. 大型の胃粘膜ひだ：過形成および非過形成性の胃疾患 large gastric folds hyperplastic and nonhyperplastic gastropathies
• 2. ガストリンの生理学 physiology of gastrin
• 3. ゾリンジャー - エリソン症候群（ガストリノーマ）の臨床症状および診断 clinical manifestations and diagnosis of zollinger ellison syndrome gastrinoma
• 4. 胃ポリープ gastric polyps
• 5. 非転移性カルチノイド腫瘍の治療およびサーベイランス treatment and surveillance of non metastatic carcinoid tumors

English Journal

• Gastric Carcinoids.

• Grozinsky-Glasberg S1, Alexandraki KI2, Angelousi A2, Chatzellis E2, Sougioultzis S3, Kaltsas G4.
• Endocrinology and metabolism clinics of North America.Endocrinol Metab Clin North Am.2018 Sep;47(3):645-660. doi: 10.1016/j.ecl.2018.04.013. Epub 2018 Jul 11.
• PMID 30098721

• The Onset and Progression of Chronic Colitis Parallels Increased Mucosal Serotonin Release via Enterochromaffin Cell Hyperplasia and Downregulation of the Serotonin Reuptake Transporter.

• Stavely R1,2, Fraser S3, Sharma S2, Rahman AA1,4, Stojanovska V1,5, Sakkal S1, Apostolopoulos V3, Bertrand P6, Nurgali K1,2.
• Inflammatory bowel diseases.Inflamm Bowel Dis.2018 Apr 23;24(5):1021-1034. doi: 10.1093/ibd/izy016.
• PMID 29668991

• Histamine-enhanced contractile responses of gastric smooth muscle via interstitial cells of Cajal in the Syrian hamster.

• Naganuma S1, Shiina T1, Yasuda S1, Suzuki Y1, Shimizu Y1,2.
• Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.Neurogastroenterol Motil.2018 Apr;30(4):e13255. doi: 10.1111/nmo.13255. Epub 2017 Nov 21.
• PMID 29159902

Japanese Journal

• 幽門洞切除によって全腫瘍を消失しえたA型胃炎に伴う多発性胃カルチノイドの1例

• 日本消化器外科学会雑誌 45(1), 30-37, 2012
• NAID 130004908080

• Pleotropic Effects of Proton Pump Inhibitors Guest Editor: Yuji NaitoGastric Epithelial Cell Modality and Proton Pump Inhibitor

• Journal of Clinical Biochemistry and Nutrition 42(3), 191-196, 2008
• NAID 130004466514

• 多発内分泌腺腫I型に合併したZollinger-Ellison症候群に多発胃カルチノイドを発症した1例

• 日本消化器外科学会雑誌 40(12), 1893-1897, 2007-12-01
• NAID 110006475256

Related Links

• Preferred Label : enterochromaffin-like cells;

Preferred Label: enterochromaffin-like cells; MeSH definition: Neuroendocrine cells in the glands of the GASTRIC MUCOSA. They produce HISTAMINE and peptides such as CHROMOGRANINS. ECL cells respond to ...

• enterochromaffin-like cells - Definition

enterochromaffin-like cells definition from the mondofacto online medical dictionary ... Bookmark with: word visualiser Go and visit our forums

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★リンクテーブル★

リンク元	「腸クロム親和性細胞様細胞」
関連記事	「like」「enterochromaffin」「cell」

「腸クロム親和性細胞様細胞」

　　[★]

英

enterochromaffin-like cell, ECL cell,enterochromaffin-like cells, ECL cells

同

ECL細胞

• 胃の壁細胞に近接して存在し、ヒスタミンを分泌する。これにより壁細胞からの胃酸分泌を促す。

「like」

　　[★]

• v.

• 好む

• prep.

• 似ている、同様の

関

alike、as well as、care for、correspond、correspondingly、equally、favor、identically、likewise、prefer、resemble、same、similar、similarly、such

　 　 　 　 　 　 　 　 　 　

「enterochromaffin」

　　[★]

• 腸クロム親和性の、エンテロクロマフィン

「cell」

　　[★] 細胞