dyschromatosis symmetrica hereditaria

遺伝性対側性色素異常症

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/06 17:54:26」(JST)

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Dyschromatosis symmetrica hereditaria (also known as "Reticulate acropigmentation of Dohi," and "Symmetrical dyschromatosis of the extremities") is a rare autosomally inherited dermatosis. It is characterized by progressively pigmented and depigmented macules, often mixed in a reticulate pattern, concentrated on the dorsal extremities.. It presents primarily in the Japanese, but has also been found to affect individuals from Europe, India and the Caribbean.

Genetics

This disease is caused by mutation in the double stranded RNA specific adenosine deaminase (ADAR1) gene. This gene is located on the long arm of chromosome 1 (1q21)

See also

• Skin lesion

References

UpToDate Contents

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• 1. 色素沈着過剰を有する患者へのアプローチ approach to the patient with hyperpigmentation disorders
• 2. The dyschromatoses

English Journal

• Mutations in the ADAR1 gene in 2 Chinese families with dyschromatosis symmetrica hereditaria.

• Zhang GL, Shi HJ, Shao MH, Li M, Mu HJ, Gu Y, Du XF, Xie P.SourceDepartment of Dermatology, Affiliated Wuxi People's Hospital, Nanjing Medical University, Wuxi, China zglamu@163.com.
• Genetics and molecular research : GMR.Genet Mol Res.2013 Jan 4;12(AOP). [Epub ahead of print]
• We investigated 2 Chinese families with dyschromatosis symmetrica hereditaria (DSH) and to search for mutations in the ADAR1 gene in these 2 pedigrees. We performed a mutation analysis of the ADAR1 gene in 2 Chinese families with DSH and reviewed all published articles regarding ADAR1 mutations re
• PMID 23315877

• What is the novel clinical finding in dyschromatosis symmetrica hereditaria?

• Tomita Y.SourceCommunity Clinic Kamisakuragi, Miyagi, Japan.
• The Journal of dermatology.J Dermatol.2013 Jan;40(1):85. doi: 10.1111/j.1346-8138.2012.01668.x. Epub 2012 Sep 14.
• PMID 22974199

Japanese Journal

• Dermoscopic features in a case of dyschromatosis symmetrica hereditaria

• OISO Naoki,MURATA Ichidai,HAYASHI Masahiro,AMATSU Akinori,YOSHIDA Masuki,SUZUKI Tamio,KAWADA Akira
• Journal of dermatology 38(1), 91-93, 2011-01-01
• NAID 10027902883

• Two novel splice site mutations of the ADAR1 gene in Chinese families with dyschromatosis symmetrica hereditaria

• WANG Xiao-Peng,LIU Yan,WANG Jun-Min,XIAO Sheng-Xiang
• Journal of dermatology 37(12), 1051-1052, 2010-12-01
• NAID 10028276015

Related Links

• 16 B．色素増加を主体とするもの

体幹とくに背部にみられる網状.

Related Pictures

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★リンクテーブル★

リンク元	「色素異常症」「遺伝性対側性色素異常症」
関連記事	「symmetric」「dyschromatosis」

「色素異常症」

　　[★]

英

pigmentation disorder, disorder of skin color

同

皮膚色素異常症

関

色素沈着障害, シャンバーグ病, 色素欠乏性色素失調症

色素異常症 NDE.258

• A. 色素の脱失を主体とするもの

• 1. 眼皮膚白皮症

• 1) OCA1型
• 2) OCA2型
• 3) OCA3型
• 4) OCA4型
• 5) Hermansky-Pudlak症候群
• 6) Chediak-Higashi症候群

• 2. 尋常性白斑
• 3. ぶち症/まだら症
• 4. Sutton母斑
• 5. Vogt-小柳-原田病
• 6. 老人性白斑
• 7. 脱色素性母斑
• 8. 偽梅毒性白斑

• B. 色素増加を主体とするもの

• 1. 雀卵斑
• 2. 肝斑
• 3. Riehl黒皮症
• 4. 摩擦黒皮症
• 5. 遺伝性対側性色素異常症
• 6. 老人性色素斑
• 7. Addison病
• 8. 光線性花弁状色素斑
• 9. 色素異常性固定紅斑

• C. 異物沈着によるもの

• 1. 柑皮症
• 2. 銀皮症
• 3. 刺青

狭義の色素異常症 dyschromatosis (1)

• 遺伝的な色素異常症は古典的には二種類ある。
• 1. 遺伝性汎発性色素異常症 dyschromatosis universalis hereditaria, DHU
• 2. 遺伝性対側性色素異常症 dyschromatosis symmetrica hereditaria, DSH

=acropigmentation symmetrica of Dohi

いずれの疾患も多くの小さい色素斑と脱色斑(macules of hypo- and hyperpigmentation)が子供のうちに出現する。

参考文献

• 1. Textbook of Pediatric Dermatology 2nd edition, Wiley-Blackwell p.1031

「遺伝性対側性色素異常症」

　　[★]

ラ

dyschromatosis symmetrica hereditaria

同

対称性先端色素沈着症 acropigmentatio symmetrica

「symmetric」

　　[★]

• adj.

• 対称性の、対称な、対称的な、対側の

関

contralateral、symmetrical、symmetrically、symmetry

「dyschromatosis」

　　[★]

• 色素異常症, 色素異常