drug metabolism

出典: meddic

Metabolism of drugs. specific agents
Metabolism of drugs. specific agents

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/01/15 13:38:10」(JST)

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  • A review on the role of quinones in renal disorders.
  • Madeo J, Zubair A, Marianne F.SourceDepartment of Medicine, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554 USA.
  • SpringerPlus.Springerplus.2013 Dec;2(1):139. Epub 2013 Apr 1.
  • Quinones are electron and proton carriers that play a primary role in the aerobic metabolism of virtually every cell in nature. Most physiological quinones are benzoquinones. They undergo highly regulated redox reactions in the mitochondria, Golgi apparatus, plasma membrane and endoplasmic reticulum
  • PMID 23577302
  • A functional variant at miR-24 binding site in B7-H2 alters susceptibility to gastric cancer in a Chinese Han population.
  • Yang P, Tang R, Zhu J, Zou L, Wu R, Zhou H, Mao Y, Li R, Hua D, Wang W, Zhang H.SourceDepartment of Oncology, The Fourth Affiliated Hospital of Soochow University, Wuxi, China; Center of Drug Metabolism and Pharmacokinetics, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
  • Molecular immunology.Mol Immunol.2013 Nov;56(1-2):98-103. doi: 10.1016/j.molimm.2013.04.010. Epub 2013 May 18.
  • A number of single nucleotide polymorphisms (SNPs) within the 3'-UTR of genes have been proved to be contributed to the risk of cancers. Here, we determined an SNP rs4819388 in the 3'-UTR of B7-H2 gene in 183 gastric cancer patients and 348 healthy controls by using polymerase chain reaction-restric
  • PMID 23688438
  • Conjugation of succinic acid to non-ionogenic amphiphilic polymers modulates their interaction with cell plasma membrane and reduces cytotoxic activity.
  • Bondar OV, Sagitova AV, Badeev YV, Shtyrlin YG, Abdullin TI.SourceKazan (Volga Region) Federal University, 18 Kremlyovskaya Street, 420008 Kazan, Russia.
  • Colloids and surfaces. B, Biointerfaces.Colloids Surf B Biointerfaces.2013 Sep 1;109:204-11. doi: 10.1016/j.colsurfb.2013.03.051. Epub 2013 Apr 9.
  • Pluronic block copolymers L61 and L121 were reacted with succinic anhydride to produce, respectively, their mono- and bisderivatives with succinic acid. The critical micelle concentration of Pluronics decreased after modification. The modification of Pluronic L61 promoted its association with the pl
  • PMID 23643917


  • Gastrectomy increases the expression of hepatic cytochrome P450 3A by increasing lithocholic acid-producing enteric bacteria in mice
  • Ishii Makoto,Toda Takahiro,Ikarashi Nobutomo,Kusunoki Yoshiki,Kon Risako,Ochiai Wataru,Machida Yoshiaki,Sugiyama Kiyoshi
  • Biological and Pharmaceutical Bulletin, 2014
  • … We had previously revealed that drug metabolism, as well as the expression level of hepatic cytochrome P450 3A (CYP3A), a drug-metabolizing enzyme, increase 12 weeks after gastrectomy in mice. …
  • NAID 130003382122
  • Repeated Treatment with Furazolidone Induces Multiple Cytochrome P450-Related Activities in Chicken Liver, but Not in Rat Liver
  • SASAKI Nobuo,MATUMOTO Tomoyuki,IKENAKA Yoshinori [他]
  • The journal of veterinary medical science 75(11), 1497-1502, 2013-11
  • NAID 40019886556
  • HOMED-BPで示された家庭血圧に基づく降圧治療のエビデンス
  • 浅山 敬,大久保 孝義,今井 潤
  • 循環器内科 74(4), 405-411, 2013-10
  • NAID 40019840702


DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing ...






drug metabolism
  • 肝臓が貢献。例外的に肺や腎で代謝されることもある


1. 第1相反応:酸化oxidation、還元reduction、加水分解hydrolysis

-OH, -COOH, SH, -O=, -NH2を付与

2. 第2相反応:抱合conjugation


生物異物代謝 (GOO.73)

Phase 1 oxygenases シトクロムP450 cytochrome P450 CYP C, Oの酸化。脱アルキル化
フラビン含有モノオキシゲナーゼ flavin-containing monooxygenase FMO N,S,Pの酸化
エポキシドヒドラーゼ(mEH, sEH) epoxide hydrolases mEH, sEH エポキシドの加水分解
Phase 2 transferases? スルホトランスフェラーゼ sulfotransferase SULT 硫酸の
UDP-グルクロノシルトランスフェラーゼ UDP-glucuronosyltransferase UGT グルクロン酸の付加
グルタチオンS-トランスフェラーゼ glutathione-S-transferase GST グルタチオンの付加
N-アセチルトランスフェラーゼ N-acetyltransferase NAT アセチル基の付加
メチルトランスフェラーゼ methyltransferase MT メチル基の付加
Other enzymes? アルコール脱水素酵素 alcohol dehydrogenases ADH アルコールの還元
アルデヒド脱水素酵素 aldehyde dehydrogenases ALDH アルデヒドの還元
NADPH/キノン酸化還元酵素 NADPH-quinone oxidoreductase NQO キノンの還元




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「use recreational drugs」
do drugs

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「administer a drug to; "They drugged the kidnapped tourist"」

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「a substance that is used as a medicine or narcotic」

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「『薬』,薬品,薬剤 / 『麻薬』,麻酔剤 / 〈人〉‘に'薬(特に麻酔剤)を与える / 〈飲食物〉‘に'(麻酔薬・毒薬などの)薬を混ぜる」


  [★] 代謝

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「the organic processes (in a cell or organism) that are necessary for life」
metabolic process

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