dothiepin

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ドチエピン

dosulepin


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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/04/28 00:10:13」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2018/02/12 15:54:57」(JST)

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英文文献

  • Case of epirubicin-induced cardiomyopathy in familial cardiomyopathy.
  • Shipman KE, Arnold I.SourceHorton Hospital, Banbury, Oxfordshire, UK.
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology.J Clin Oncol.2011 Jun 20;29(18):e537-8. Epub 2011 Apr 11.
  • PMID 21482996
  • Successful reversal of life threatening cardiac effect following dosulepin overdose using intravenous lipid emulsion.
  • Boegevig S, Rothe A, Tfelt-Hansen J, Hoegberg LC.SourceDepartment of Anaesthesiology, Bispebjerg University Hospital, Copenhagen, Denmark.
  • Clinical toxicology (Philadelphia, Pa.).Clin Toxicol (Phila).2011 Apr;49(4):337-9. doi: 10.3109/15563650.2011.566880.
  • CONTEXT.?We report a successful acute reversal of potential life threatening QRS complex widening and prolonged QT interval following dosulepin overdose using intravenous lipid emulsion 20% in an unstable patient. CASE DETAILS.?A 36-year-old female following the ingestion of 5.25 g of dosulepin.
  • PMID 21563912

和文文献

  • Effect of Cytochrome P450 2C19 and 2C9 Amino Acid Residues 72 and 241 on Metabolism of Tricyclic Antidepressant Drugs
  • Attia Tamer Zekry,Yamashita Taku,Hammad Mohamed Abdelkhalek,Hayasaki Akinori,Sato Takumi,Miyamoto Masayoshi,Yasuhara Yuki,Nakamura Takashi,Kagawa Yusuke,Tsujino Hirofumi,Omar Mahmoud Ahmed,Abdelmageed Osama Hassan,Derayea Sayed Mohamed,Uno Tadayuki
  • Chemical and Pharmaceutical Bulletin 62(2), 176-181, 2014
  • … Reciprocal mutants for both CYP2C19 and 2C9 were produced, and their metabolic activities and spectroscopic properties were examined using three tricyclic antidepressant (TCA) drugs: amitriptyline, imipramine, and dothiepin. …
  • NAID 130003390760
  • Comparison of Cytochrome P450 Mediated Metabolism of Three Central Nervous System Acting Drugs
  • Attia Tamer Zekry,Yamashita Taku,Miyamoto Masayoshi [他],Koizumi Atsushi,Yasuhara Yuki,Node Jun-ichi,Erikawa Yumi,Komiyama Yumi,Horii Chiaki,Yamada Mayu,Omar Mahmoud Ahmed,Abdelmageed Osama Hassan,Derayea Sayed Mohamed,Uno Tadayuki
  • Chemical and Pharmaceutical Bulletin 60(12), 1544-1549, 2012
  • … In this study, the metabolic activities of three major hepatic CYP isoforms (2C19, 2D6, and 3A4) were investigated on structurally different central nervous system (CNS) acting drugs, amitriptyline, fluphenazine, and dothiepin. … By using our novel in vitro evaluation system, we could compare the kinetic parameters for the metabolism of fluphenazine and dothiepin for the first time. …
  • NAID 130001852550
  • Extractive Colorimetric Method for the Determination of Dothiepin Hydrochloride and Risperidone in Pure and in Dosage Forms
  • Hassan Wafaa El-Sayed
  • Chemical & pharmaceutical bulletin 56(8), 1092-1096, 2008-08-01
  • … Three rapid, simple, reproducible and sensitive extractive colorimetric methods (A-C) for assaying dothiepin hydrochloride (I) and risperidone (II) in bulk sample and in dosage forms were investigated. …
  • NAID 110006838315

関連リンク

Dosulepin (INN), formerly known as dothiepin (BAN), is a tricyclic antidepressant (TCA). It is sold under the brand names Prothiaden, Dothep, Thaden and Dopress. Dosulepin blocks the reuptake of serotonin and norepinephrine in the brain, ...

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dosulepin」

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dosulepin hydrochloridedothiepin


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dothiepin
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