UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia.

Liu H1, Zhang Y1, Wu H1, D'Alessandro A1, Yegutkin GG1, Song A1, Sun K1, Li J1, Cheng NY1, Huang A1, Edward Wen Y1, Weng TT1, Luo F1, Nemkov T1, Sun H1, Kellems RE1, Karmouty-Quintana H1, Hansen KC1, Zhao B1, Subudhi AW1, Jameson-Van Houten S1, Julian CG1, Lovering AT1, Eltzschig HK1, Blackburn MR1, Roach RC1, Xia Y2.
Circulation.Circulation.2016 Aug 2;134(5):405-21. doi: 10.1161/CIRCULATIONAHA.116.021311.
BACKGROUND: High altitude is a challenging condition caused by insufficient oxygen supply. Inability to adjust to hypoxia may lead to pulmonary edema, stroke, cardiovascular dysfunction, and even death. Thus, understanding the molecular basis of adaptation to high altitude may reveal novel therapeut
PMID 27482003

Relationship between chronic disturbance of 2,3-diphosphoglycerate metabolism in erythrocytes and Alzheimer disease.

Kosenko EA, Aliev G1, Kaminsky YG.
CNS & neurological disorders drug targets.CNS Neurol Disord Drug Targets.2016;15(1):113-23.
Alzheimer disease (AD) is one of the most common neurodegenerative disorders widely occurring among the elderly. The pathogenic mechanisms involved in the development of this disease are still unknown. In AD, in addition to brain, a number of peripheral tissues and cells are affected, including eryt
PMID 26295825

Microarray and Co-expression Network Analysis of Genes Associated with Acute Doxorubicin Cardiomyopathy in Mice.

Wei SN1,2,3, Zhao WJ1,2,3, Zeng XJ1,2,3, Kang YM4, Du J1,2,3, Li HH5,6,7.
Cardiovascular toxicology.Cardiovasc Toxicol.2015 Oct;15(4):377-93. doi: 10.1007/s12012-014-9306-7.
Clinical use of doxorubicin (DOX) in cancer therapy is limited by its dose-dependent cardiotoxicity. But molecular mechanisms underlying this phenomenon have not been well defined. This study was to investigate the effect of DOX on the changes of global genomics in hearts. Acute cardiotoxicity was i
PMID 25575753