dimercaprol

出典: meddic

ジメルカプロール

2,3-dimercaptopropanol, British antilewisite, BAL



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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/05/30 17:45:05」(JST)

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英文文献

  • Differences in the substrate binding regions of renal organic anion transporters 1 (OAT1) and 3 (OAT3).
  • Astorga B, Wunz TM, Morales M, Wright SH, Pelis RM.SourceDept. of Pharmacology, College of Medicine, University of Arizona, Tucson, USA.
  • American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2011 Aug;301(2):F378-86. Epub 2011 May 4.
  • This study examined the selectivity of organic anion transporters OAT1 and OAT3 for structural congeners of the heavy metal chelator 2,3-dimercapto-1-propanesulfonic acid (DMPS). Thiol-reactive reagents were also used to test structural predictions based on a homology model of OAT1 structure. DMPS w
  • PMID 21543413
  • Metal mercury poisoning in two boys initially treated for brucellosis in Mashhad, Iran.
  • Sasan MS, Hadavi N, Afshari R, Mousavi SR, Alizadeh A, Balali-Mood M.SourceDepartment of Pediatrics, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Human & experimental toxicology.Hum Exp Toxicol.2011 Aug 1. [Epub ahead of print]
  • Elemental mercury (Hg) is the only metal which evaporates in room temperature and its inhalation may cause toxicity. Hg poisoning may occur by mishandling the metal, particularly in children who play with it. Wide-spectrum of the clinical presentations of chronic Hg poisoning may cause misdiagnosis,
  • PMID 21803782
  • Differential stability of lead sulfide nanoparticles influences biological responses in embryonic zebrafish.
  • Truong L, Moody IS, Stankus DP, Nason JA, Lonergan MC, Tanguay RL.SourceNanotoxicology Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.
  • Archives of toxicology.Arch Toxicol.2011 Jul;85(7):787-98. Epub 2010 Dec 8.
  • As the number of nanoparticle-based products increase in the marketplace, there will be increased potential for human exposures to these engineered materials throughout the product life cycle. We currently lack sufficient data to understand or predict the inherent nanomaterial characteristics that d
  • PMID 21140132

和文文献

  • Strategies for Safe and Effective Therapeutic Measures for Chronic Arsenic and Lead Poisoning
  • KALIA Kiran,FLORA Swaran J. S.
  • Journal of occupational health 47(1), 1-21, 2005-01
  • … 2, 3-dimercaprol (BAL) has long been the mainstay of chelation therapy for lead or arsenic poisoning. …
  • NAID 110004568615
  • Cuprin Sulfate Intoxication with Rhabdomyolysis, Treated with Chelating Agents and Blood Purification
  • TAKEDA Taichi,YUKIOKA Tetuo,SHIMAZAKI Syuji
  • Internal medicine 39(3), 253-255, 2000-03
  • … The patient was successfully treated with dimercaprol, penicillamine, direct hemoperfusion and hemodiafiltration. …
  • NAID 10006994818
  • STUDY ON THE MECHANISM BEHIND ADJUVANT ACTION OF DIETHYLETHOXYMETHYLENE MALONATE ENHANCING THE RECTAL ABSORPTION OF CEFMETAZOLE AND LYSOZYME
  • NISHIHATA TOSHIAKI,MIYAKE MASATOSHI,KAMADA AKIRA
  • Journal of pharmacobio-dynamics 7(9), 607-613, 1984-09
  • … Since an increase of cefmetazole transport was found when concentration of nonprotein sulfhydryls in rectal tissue was decreased by the presence of either DEEMM or DEM in the study using in vitro everted sac method and the enhancement of cefmetazole absorption by the coadministration of either DEEMM or DEM was suppressed by the treatment with dimercaprol, membrane permeability of rectal tissue seems to be regulated by the concentration of nonprotein sulfhydryls in rectal tissue. …
  • NAID 110003637797

関連リンク

dimercaprol [di″mer-kap´rol] a colorless, liquid chelating agent used in the treatment of heavy metal poisoning; it forms a relatively stable compound with arsenic, mercury, gold, and certain other metals, thus protecting the vital ...
dimercaprol di·mer·cap·rol (dī'mər-kāp'rôl, -rōl) n. A chelating agent developed as an antidote for lewisite and other arsenical poisons, also used as an antidote for antimony, bismuth, chromium, mercury, gold, and nickel poisoning.

関連画像

Dimercaprol Injection - Wuhan Grand Dimercaprol - brand name list from Drugs File: Dimercaprol -3D-balls.pngOpiniones de DimercaprolDimercaprolDimercaprol


★リンクテーブル★
リンク元ジメルカプロール」「BAL

ジメルカプロール」

  [★]

dimercaprol
dimercaprolum
BAL(British anti-Lewisite)
バル


  • 毒ガスのルイサイト(Lewisite)を解毒する薬物として見いだされた
  • C3H8OS2
1つのヒドロキシル基と2つのSH基をもつ
  • キレート剤。重金属解毒剤
  • 金属イオンに対して高親和性を有する

作用機序

  • 金属イオン-SH基間の結合を阻害
  • 金属イオンの排泄を促進する

適応

  • ヒ素、水銀、鉛、銅、ビスマス、クロム、アンチモンの中毒

注意

  • 鉄、カドミウム、セレンの中毒には使用不可


BAL」

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