dihydropteroate synthase

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/16 14:16:26」(JST)

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  • Pneumocystis jirovecii dihydropteroate synthase gene mutations in a group of HIV-negative immunocompromised patients with Pneumocystis pneumonia.
  • Long Y, Zhang C, Su L, Que C.
  • Experimental and therapeutic medicine.Exp Ther Med.2014 Dec;8(6):1825-1830. Epub 2014 Oct 3.
  • The purpose of this study was to investigate dihydropteroate synthase (DHPS) mutations and their clinical context in non-HIV-infected patients with Pneumocystis pneumonia (PCP). DHPS genes in respiratory samples collected from HIV-negative patients with PCP presented between January 2008 and April 2
  • PMID 25371739
  • Structure-Based Design and Development of Functionalized Mercaptoguanine Derivatives as Inhibitors of the Folate Biosynthesis Pathway Enzyme 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus.
  • Dennis ML1, Chhabra S, Wang ZC, Debono A, Dolezal O, Newman J, Pitcher NP, Rahmani R, Cleary B, Barlow N, Hattarki M, Graham B, Peat TS, Baell JB, Swarbrick JD.
  • Journal of medicinal chemistry.J Med Chem.2014 Nov 26;57(22):9612-26. doi: 10.1021/jm501417f. Epub 2014 Nov 12.
  • 6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK), an enzyme from the folate biosynthesis pathway, catalyzes the pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin and is a yet-to-be-drugged antimicrobial target. Building on our previous discovery that 8-mercaptoguanine (
  • PMID 25357262
  • AIDS-related Pneumocystis jirovecii genotypes in French Guiana.
  • Le Gal S1, Blanchet D2, Damiani C3, Guéguen P4, Virmaux M5, Abboud P2, Guillot G2, Kérangart S5, Merle C5, Calderon E6, Totet A3, Carme B7, Nevez G8.
  • Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.Infect Genet Evol.2014 Nov 5;29C:60-67. doi: 10.1016/j.meegid.2014.10.021. [Epub ahead of print]
  • The study described Pneumocystis jirovecii (P. jirovecii) multilocus typing in seven AIDS patients living in French Guiana (Cayenne Hospital) and seven immunosuppressed patients living in Brest, metropolitan France (Brest Hospital). Archival P. jirovecii specimens were examined at the dihydropteroat
  • PMID 25445659


  • ニューモシスチスにおける薬物標的分子の変異と今後の展開
  • 高橋 孝
  • 日本医真菌学会雑誌 = Japanese journal of medical mycology 50(2), 67-73, 2009-04-30
  • … ソキサゾールとトリメトプリム)合剤を第1選択として,ペンタミジンやアトバコンなどが第2選択として選択される.<I>Pc</I>に対する薬物標的は,(1)サルファメソキサゾール → dihydropteroate synthase(DHPS),(2)トリメトプリム → dihydrofolate reductase,(3)アトバコン → cytochrome <I>b</I>であり,その耐性機序として標的をコードする遺伝子変異がいわれている.特に,DHPSの活性中心で …
  • NAID 10024793243
  • 沖縄県の豚由来Toxoplasma gondiiの遺伝子型別(短報)(寄生虫病学)
  • 座喜味 聡,喜屋 武向子,大城 守,杉本 千尋,藤崎 幸蔵
  • The journal of veterinary medical science 68(4), 401-404, 2006-04-25
  • … から得た有病変豚リンパ節101検体のDNAを抽出後,Toxoplasma gondiiのSAG2遺伝子をターゲットにnested PCRを実施したところ57検体が陽性だった.そのうち49が制限酵素による型別が可能で,22(44.9%)がI型,23(46.9%)がII型,4(8.2%)がIII型だった.またサルファ剤耐性と関連するとされるdihydropteroate synthase遺伝子がnested PCRにより57検体中40で増幅され,制限酵素パターンとシーケンスによるとこれらは全て野生型(感受性)だった. …
  • NAID 110004758098
  • らい菌のダプソン耐性変異
  • 甲斐 雅規
  • 日本ハンセン病学会雑誌 = Japanese journal of leprosy 73(3), 221-226, 2004-09-30
  • … The relation between diaminodiphenylsulfone (called dapsone)-resistance and point mutations of the dihydropteroate synthase (DHPS) gene was analyzed using dapsone resistant <I>Mycobacterium leprae</I> …
  • NAID 130000760206


I. Introduction Dihydropteroate synthase (DHPS) is an enzyme involved in the Bacillus anthracis folate synthesis pathway. The enzyme has two binding pockets: one which binds dihydropterin pyrophosphate (DHPP) and one which ...
In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthase, DHPS. DHPS catalyses the conversion of PABA (para-aminobenzoate) to dihydropteroate, a key step in folate synthesis.


Dihydropteroate Synthase; Dihydropteroate Dihydropteroate synthase; Dihydropteroate Image Details Add to favoritesDihydropteroate Synthase Gene Mutations in www.biomedcentral.com - FigureDihydropteroate Synthase (Dihydropteroate




dihydropteroate synthase



dihydropteroate synthase



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