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「digitalis preparation used to treat congestive heart failure or cardiac arrhythmia」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/03 00:04:19」(JST)

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  • Simultaneous quantification of digoxin, digitoxin, and their metabolites in serum using high performance liquid chromatography-tandem mass spectrometry.
  • Bylda C1, Thiele R, Kobold U, Volmer DA.
  • Drug testing and analysis.Drug Test Anal.2015 Mar 4. doi: 10.1002/dta.1781. [Epub ahead of print]
  • The study describes an LC-MS/MS method for simultaneous quantification of the cardiac glycosidic drugs digoxin and digitoxin and several of their metabolites. The assay represents a useful reference method for immunoassay-based tests, which are easily biased by the presence of metabolites of the tar
  • PMID 25735870
  • Cardiac glycoside activities link Na(+)/K(+) ATPase ion-transport to breast cancer cell migration via correlative SAR.
  • Magpusao AN1, Omolloh G, Johnson J, Gascón J, Peczuh MW, Fenteany G.
  • ACS chemical biology.ACS Chem Biol.2015 Feb 20;10(2):561-9. doi: 10.1021/cb500665r. Epub 2014 Nov 26.
  • The cardiac glycosides ouabain and digitoxin, established Na(+)/K(+) ATPase inhibitors, were found to inhibit MDA-MB-231 breast cancer cell migration through an unbiased chemical genetics screen for cell motility. The Na(+)/K(+) ATPase acts both as an ion-transporter and as a receptor for cardiac gl
  • PMID 25334087
  • Rapid quantification of digitoxin and its metabolites using differential ion mobility spectrometry-tandem mass spectrometry.
  • Bylda C1, Thiele R, Kobold U, Bujotzek A, Volmer DA.
  • Analytical chemistry.Anal Chem.2015 Feb 17;87(4):2121-8. doi: 10.1021/ac503187z. Epub 2015 Jan 26.
  • This study focuses on the quantitative analysis of the cardiac glycoside drug digitoxin and its three main metabolites digitoxigenin-bisdigitoxose, digitoxigenin-monodigitoxose, and digitoxigenin using electrospray ionization-differential ion mobility spectrometry-tandem mass spectrometry (ESI-DMS-M
  • PMID 25588102


  • Perfectly regioselective acylation of a cardiac glycoside, digitoxin, via catalytic amplification of the intrinsic reactivity
  • Yoshida Keisuke,Furuta Takumi,Kawabata Takeo
  • Tetrahedron Letters 51(37), 4830-4832, 2010-09-15
  • … Organocatalytic regioselective acylation of digitoxin has been developed. …
  • NAID 120002484958
  • Interaction of Polyphenols with Proteins : Binding of (-)-Epigallocatechin Gallate to Serum Albumin, Estimated by Induced Circular Dichroism
  • NOZAKI Akiko,HORI Mami,KIMURA Toshikiro,ITO Hideyuki,HATANO Tsutomu
  • Chemical & pharmaceutical bulletin 57(2), 224-228, 2009-02-01
  • … Double-reciprocal plot analyses showed the competitive relations with the site-I-(PB and tolbutamide, TB) and site-II-binding drugs (DP and ibuprofen, IP) indicating the binding of EGCG to sites I and II on HSA, while digitoxin (DG), a site-III-binding drug, did not affect the binding of EGCG. …
  • NAID 110007042056
  • Interaction of Polyphenolic Metabolites with Human Serum Albumin: A Circular Dichroism Study
  • Nozaki Akiko,Kimura Toshikiro,Ito Hideyuki,Hatano Tsutomu
  • Chemical and Pharmaceutical Bulletin 57(9), 1019-1023, 2009
  • … The addition of digitoxin did not affect the induced CD of the polyphenolic acids examined. …
  • NAID 130000124205


Digitoxinとは?goo Wikipedia (ウィキペディア) 。出典:Wikipedia(ウィキペディア)フリー百科事典。 Digitoxinとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ メニューへスキップ 本文へ ...
digitoxin 【名】《薬学》ジギトキシン - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。 ... 英和・和英 対訳データオンライン検索 ...


Description Digitoxin.pngDigitoxin:ジギトキシン (digitoxin Digitoxin (above) and digoxin (below DigitoxinFile:Digitoxin.svg




cardiac glycoside, cardiotonic glycoside
強心ステロイド cardiotonic steroid、植物心臓毒 plant heart poison