differentiating agents

出典: meddic

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  • Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.
  • Veigel D1, Wagner R, Stübiger G, Wuczkowski M, Filipits M, Horvat R, Benhamú B, López-Rodríguez ML, Leisser A, Valent P, Grusch M, Hegardt FG, García J, Serra D, Auersperg N, Colomer R, Grunt TW.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2015 May 1;136(9):2078-90. doi: 10.1002/ijc.29261. Epub 2014 Nov 3.
  • Ovarian cancer (OC) is caused by genetic aberrations in networks that control growth and survival. Importantly, aberrant cancer metabolism interacts with oncogenic signaling providing additional drug targets. Tumors overexpress the lipogenic enzyme fatty acid synthase (FASN) and are inhibited by FAS
  • PMID 25302649
  • An evaluation of a human stem cell line to identify risk of developmental neurotoxicity with antiepileptic drugs.
  • Cao WS1, Livesey JC2, Halliwell RF3.
  • Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2015 Apr;29(3):592-9. doi: 10.1016/j.tiv.2015.01.010. Epub 2015 Jan 27.
  • Determination of the impact of a drug on human brain development relies instead on surrogate animal studies. Here we have exploited the human stem cell line, TERA2.cl.SP12 to differentiate into neurons and addressed their value as an in vitro model to evaluate the risk of developmental neurotoxicity
  • PMID 25637331


  • Differentiation of bacterial and non-bacterial community-acquired pneumonia by thin-section computed tomography.
  • Ito Isao,Ishida Tadashi,Togashi Kaori,Niimi Akio,Koyama Hiroshi,Ishimori Takayoshi,Kobayashi Hisataka,Mishima Michiaki
  • European journal of radiology 72(3), 388-395, 2009-12
  • … BACKGROUND AND OBJECTIVE: The management of community-acquired pneumonia (CAP) depends, in part, on the identification of the causative agents. … The objective of this study was to determine the potential of thin-section computed tomography (CT) in differentiating bacterial and non-bacterial pneumonia. …
  • NAID 120002576696
  • Differentiation-associated alteration in sensitivity to apoptosis induced by (-)-epigallocatechin-3-O-gallate in HL-60 cells
  • Okada Norihisa,Tanabe Hiroki,Tazoe Hideaki,Ishigami Yoko,Fukutomi Ryuuta,Yasui Kensuke,Isemura Mamoru
  • Biomedical Research 30(4), 201-206, 2009
  • … HL-60 cells treated with three differentiating agents were found to be resistant to EGCG-mediated apoptosis as compared with undifferentiated cells. …
  • NAID 130004903753
  • 筋萎縮性側索硬化症の臨床病型(神経内科学教室岩田誠教授退任記念特別号)
  • 佐々木 彰一
  • 東京女子医科大学雑誌 78(臨時増刊号), E19-E25, 2008-02-25
  • … Typical amyotrophlc lateral sclerosis (ALS)/motor neuron disease (MND) is not hard to diagnose, but we may face some difficulties in differentiating between atypical forms of ALS/MND which account for about 20% and other non-ALS diseases. … Clinical trials of new therapeutic agents have been performed, on the assumption that patients with ALS/MND have the same underlying etiology, addressing the heterogeneous population of the patients under a single diagnostic category. …
  • NAID 110007524776


Topics include: molecular control of embryonic stem cell renewal, normal and cancer stem cell niches, therapeutic potential of mesenchymal stem cell differentiation, and cancer differentiating agents in stem cell-based therapy ...
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  • n.
  • 代行者、代理人。代理業者
  • 政府職員、官吏
  • ある後位をする人、ある作用をするもの。動員、動力因、作用因。(文法)動作主。科学的変化を起こさせるもの、薬品、~剤。病原体
agonistagonisticattorneydelegatedrugetiologic agentfomesfomitesmediatorpathogenpathogenicpharmaceutical preparationvectorvehicle

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「a substance that exerts some force or effect」

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「a businessman who buys or sells for another in exchange for a commission」
factor, broker

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「any agent or representative of a federal agency or bureau」
federal agent

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「a representative who acts on behalf of other persons or organizations」

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「an active and efficient cause; capable of producing a certain effect; "their research uncovered new disease agents"」

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「『代理人』;周旋人 / 働き(作用)を起こすもの;作用物,薬剤 / (政府機関,特にFBI,CIAなどの)部員,機関員」