desipramine

出典: meddic

デシプラミン

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「a tricyclic antidepressant drug that activates the psychomotor system」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/01/18 21:11:46」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/29 16:25:22」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/10/28 21:58:50」(JST)

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UpToDate Contents

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英文文献

  • Effects of desvenlafaxine on the pharmacokinetics of desipramine in healthy adults.
  • Nichols AI, Madelyn A, Chen Y, Behrle JA, Frick G, Paul J.SourceaPfizer Inc., formerly Wyeth Research, Collegeville, Pennsylvania bDepartment of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York, USA.
  • International clinical psychopharmacology.Int Clin Psychopharmacol.2013 Mar;28(2):99-105. doi: 10.1097/YIC.0b013e32835c1f49.
  • The results of two single-center, two-period, open-label trials that evaluated the effects of multiple doses of desvenlafaxine on the pharmacokinetics of desipramine, a cytochrome P450 (CYP) 2D6 enzyme substrate, are presented. Healthy individuals aged 18-45 years were administered a single oral dos
  • PMID 23221858
  • Active behaviours produced by antidepressants and opioids in the mouse tail suspension test.
  • Berrocoso E, Ikeda K, Sora I, Uhl GR, Sánchez-Blázquez P, Mico JA.SourceNeuropsychopharmacology Research Group, Psychobiology Area, Department of Psychology, University of Cadiz, Cadiz, Spain.
  • The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP).Int J Neuropsychopharmacol.2013 Feb;16(1):151-62. doi: 10.1017/S1461145711001842. Epub 2012 Jan 5.
  • Most classical preclinical tests to predict antidepressant activity were initially developed to detect compounds that influenced noradrenergic and/or serotonergic activity, in accordance with the monoaminergic hypothesis of depression. However, central opioid systems are also known to influence the
  • PMID 22217458

和文文献

  • Pharmacological Interaction With the Sigma1 (σ1)-Receptor in the Acute Behavioral Effects of Antidepressants
  • Villard Vanessa,Meunier Johann,Chevallier Nathalie,Maurice Tangui
  • Journal of Pharmacological Sciences 115(3), 279-292, 2011
  • … The SSRI fluoxetine and sertraline, but not fluvoxamine, and the tricyclic antidepressants imipramine, desipramine, and amitriptyline were also effective. …
  • NAID 130000663391
  • A Novel Approach to the Prediction of Drug-Drug Interactions in Humans Based on the Serum Incubation Method
  • SHIBATA Yoshihiro,TAKAHASHI Hiroyuki,CHIBA Masato,ISHII Yasuyuki
  • Drug metabolism and pharmacokinetics 23(5), 328-339, 2008-10-25
  • NAID 10024384558

関連リンク

Desipramine (also known as desmethylimipramine) is a tricyclic antidepressant ( TCA). It inhibits the reuptake of norepinephrine and to a lesser extent serotonin. It is used to treat depression, but not considered a first line treatment since the ...
The anticholinergic actions of desipramine are responsible for many of the commonly observed side effects of the drug. Desipramine causes ECG changes such as prolongation of the P-R interval and a decreased magnitude with an increased ...

関連画像

Desipramine 25mg (180 pills)Desipramine hydrochloride C18H22N2.HCl [58 Description Desipramine.pngDescription Desipramine.svgwhat is desipramine norpramin desipramine Desipramine hydrochloride ≥98% (TLC


★リンクテーブル★
リンク元抗うつ薬」「三環系抗うつ薬」「デシプラミン

抗うつ薬」

  [★]

antidepressant, antidepressants
薬理学、そううつ病、精神疾患

作用機序

三環系抗うつ薬 tricyclic antidepressant

  • 2つの説がある。
  • 1. (急性作用)シナプス前膜におけるノルアドレナリン、セロトニンの再取り込み↓→シナプス間隙における薬剤濃度↑
  • 2. (慢性作用)(2週間後)シナプス後膜における受容体の数↓
  • 慢性作用はシナプス間隙のノルアドレナリン、セロトニン濃度が上昇した結果、シナプス後膜の受容体が減少したために出現すると考えられる。

抗うつ薬

  • 三環系
  • 四環系
ミルナシプラン milnacipran
  • 非定型抗うつ薬 atypical agent




三環系抗うつ薬」

  [★]

tricyclic antidepressant, tricyclic anti-depressant agent
抗うつ薬四環系抗うつ薬
イミプラミン

概念

  • 環状の構造を三つ持つ抗うつ薬
  • 治療効果発現には2-3週間必要

種類

作用機序

副作用

  • 抗コリン作用
視力障害、口渇、便秘、尿閉
頻脈
  • α1ブロック作用
起立性低血圧
血中ノルアドレナリンの上昇
  • 抗ヒスタミン作用
鎮静、眠気



デシプラミン」

  [★]

desipramine
塩酸デシプラミン desipramine hydrochloride
デスメチルイミプラミン desmethylimipramine
Norpramin, Pertofrane
抗うつ薬





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