関: cytoplasmic receptor、nuclear hormone receptor、nuclear receptor

WordNet

of or relating to or constituting the nucleus of an atom; "nuclear physics"; "nuclear fission"; "nuclear forces"
(weapons) deriving destructive energy from the release of atomic energy; "nuclear war"; "nuclear weapons"; "atomic bombs" (同)atomic
constituting or like a nucleus; "annexation of the suburban fringe by the nuclear metropolis"; "the nuclear core of the congregation"
of or relating to or constituting the nucleus of a cell; "nuclear membrane"; "nuclear division"
of or relating to cytoplasm (同)cytoplasmatic
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

《語・句・節を対等に結んで》…『と』…,…や…,および / 《数詞を結合して》…『足す』…,…に加えて / …『しかも』…,…して,同時に… / 《時間的に》『そして』,それから,すると(and then) / 《当然の帰結として》…『ので』,…だから(and so) / 《おもに話》《命令文などの後で》『そうすれば』,そうしたら / 《追加・強調して》それに,しかも / 《対照的な内容を導いて》ところが,しかし(but) / 《譲歩的に》それなのに,それでいながら / 《A and Bで一体の関係を表して》《単数扱い》 / 《同一語を反復して多数・継続などを表して》 / 《同一の複数名詞を結合して変化・種類などを表して》 / 《話》《「形容詞+and+形容詞」の形で前の形容詞が後に副詞的に働く》 / 《話》《「動詞come, goなど+and+動詞」の形でandとその後の動詞が不定詞の働きをして》 / 《「動詞+and+動詞」の形で後の動詞が現在分詞の意を表して》 / 《話》《文頭において前の質問・意見などに同意を示して》そうとも,そして(Yes!and) / 《話》《文頭に置いて驚き・疑念・非難などを表して》ほんとうに;…なのに
『核の』,細胞核の / [『原子』]『核の』
細胞質の
=sense organ / 受信装置
(次にくる語の発音が母音で始まるときに用いる) / (子音[h]で始まり第1音節に強勢のない語の場合はanを用いることがある.ただし,この場合は[h]を発音しない)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/17 18:07:05」(JST)

wiki en

Intracellular receptors are receptors located inside the cell rather than on its cell membrane. Classic hormones that use intracellular receptors include thyroid and steroid hormones. Examples are the class of nuclear receptors located in the cell nucleus and cytoplasm and the IP₃ receptor located on the endoplasmic reticulum. The ligands that bind to them are usually intracellular second messengers like inositol trisphosphate (IP₃) and extracellular lipophilic hormones like steroid hormones. Some intracrine peptide hormones also have intracellular receptors.

Examples

transcription factors
- nuclear receptors

other
- Sigma1 (neurosteroids)
- IP₃ receptor (inositol triphosphate, IP₃)

External links

Nuclear Receptor journal homepage
Nuclear receptor resource at Georgetown University
Nuclear receptor signalling atlas (NURSA, open-access journal)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 甲状腺ホルモンの作用 thyroid hormone action
2. T細胞受容体シグナル伝達 t cell receptor signaling
3. 複合免疫不全 combined immunodeficiencies
4. 赤血球産生調節 regulation of erythropoiesis
5. ステロイド抵抗性喘息 glucocorticoid resistant asthma

English Journal

p38 MAP Kinase Links CAR Activation and Inactivation in the Nucleus via Phosphorylation at Threonine 38.

Hori T1, Moore R1, Negishi M2.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2016 Jun;44(6):871-6. doi: 10.1124/dmd.116.070235. Epub 2016 Apr 13.
Nuclear receptor constitutive androstane receptor (CAR, NR1I3), which regulates hepatic drug and energy metabolisms as well as cell growth and death, is sequestered in the cytoplasm as its inactive form phosphorylated at threonine 38. CAR activators elicit dephosphorylation, and nonphosphorylated CA
PMID 27074912

(68)Ga-DOTATATE PET in juvenile angiofibroma.

Gronkiewicz Z1, Kukwa W1, Krolicki L2, Cyran-Chlebicka A3, Pawlak D4, Stankiewicz C5, Krzeski A1, Górnicka B3, Wolosz D3, Kunikowska J2.
Future oncology (London, England).Future Oncol.2016 Jun;12(12):1483-91. doi: 10.2217/fon-2015-0074. Epub 2016 Mar 14.
BACKGROUND: As somatostatin receptors (SSTRs) may be overexpressed in rapidly growing vessels, the aim of this study was the analysis of in vivo and in vitro SSTR2A expression in juvenile angiofibroma (JA).MATERIAL & METHODS: A group of six male adolescents with a diagnosis of primary, recurrent
PMID 26971784

Association between cytoplasmic CRABP2, altered retinoic acid signaling, and poor prognosis in glioblastoma.

Liu RZ1, Li S1, Garcia E1, Glubrecht DD1, Yin Poon H1, Easaw JC2, Godbout R1.
Glia.Glia.2016 Jun;64(6):963-76. doi: 10.1002/glia.22976. Epub 2016 Feb 19.
Retinoic acid (RA), a metabolite of vitamin A, is required for the regulation of growth and development. Aberrant expression of molecules involved in RA signaling has been reported in various cancer types including glioblastoma multiforme (GBM). Cellular retinoic acid-binding protein 2 (CRABP2) has
PMID 26893190

Japanese Journal

Podocyte Injury Caused by Indoxyl Sulfate, a Uremic Toxin and Aryl-Hydrocarbon Receptor Ligand

Ichii Osamu,Otsuka-Kanazawa Saori,Nakamura Teppei,Ueno Masaaki,Kon Yasuhiro,Chen Weiping,Rosenberg Avi Z.,Kopp Jeffrey B.
PLOS one 9(9), e108448, 2014-09-22
… Indoxyl sulfate is a uremic toxin and a ligand of the aryl-hydrocarbon receptor (AhR), a transcriptional regulator. … Elevated serum indoxyl sulfate levels may contribute to progressive kidney disease and associated vascular disease. … We asked whether indoxyl sulfate injures podocytes in vivo and in vitro. …
NAID 120005525223

Fisetin Inhibits Osteoclastogenesis Through Prevention of RANKL-Induced ROS Production by Nrf2-Mediated Up-regulation of Phase Ⅱ Antioxidant Enzymes

Sakai Eiko,Shimada-Sugawara Megumi,Yamaguchi Yu [他],Sakamoto Hiroshi,Fumimoto Reiko,Fukuma Yutaka,Nishishita Kazuhisa,Okamoto Kuniaki,Tsukuba Takayuki
Journal of Pharmacological Sciences 121(4), 288-298, 2013
… Osteoclasts (OCLs) are multinucleated bone-resorbing cells that are differentiated by stimulation with receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor. … Fisetin inhibited the formation of OCLs in a dose-dependent manner and suppressed the bone-resorbing activity of OCLs. …
NAID 130003382582

6,4′-Dihydroxy-7-methoxyflavanone Inhibits Osteoclast Differentiation and Function

Im Nam-Kyung,Choi Je-Yong,Oh Hyuncheol,Kim Youn-Chul,Jeong Gil-Saeng
Biological and
… It has been known that DMF has antioxidant, anti-inflammatory and neuroprotective effects. … In this study, we determined DMF's efficacy on osteoclasts differentiation and function using in vitro bone marrow macrophage osteoclast differentiation culture system. … DMF inhibited receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis dose dependently. …
NAID 130003361434

★リンクテーブル★

リンク元	「nuclear receptor」「nuclear hormone receptor」「cytoplasmic receptor」「細胞質および核内受容体」
関連記事	「cytoplasmic」「nuclear」「nuclear receptor」