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(biochemistry) a class of hemoprotein whose principal biological function is electron transfer (especially in cellular respiration)

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1. 貧食細胞機能の原発性疾患：概要 primary disorders of phagocytic function an overview
2. 慢性肉芽腫性疾患：病因、臨床症状、および診断 chronic granulomatous disease pathogenesis clinical manifestations and diagnosis

The TLR7/8 agonist CL097 primes N-formyl-methionyl-leucyl-phenylalanine-stimulated NADPH oxidase activation in human neutrophils: critical role of p47phox phosphorylation and the proline isomerase Pin1.

Makni-Maalej K, Boussetta T, Hurtado-Nedelec M, Belambri SA, Gougerot-Pocidalo MA, El-Benna J.SourceINSERM, U773, Centre de Recherche Biomédicale Bichat Beaujon, Paris F-75018, France.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2012 Nov 1;189(9):4657-65. doi: 10.4049/jimmunol.1201007. Epub 2012 Sep 21.
Superoxide anion production by the neutrophil NADPH oxidase plays a key role in host defense; however, excessive superoxide production is believed to participate to inflammatory reactions. Neutrophils express several TLR that recognize a variety of microbial motifs or agonists. The interaction betwe
PMID 23002436

Effects of IFN-γ on intracellular trafficking and activity of macrophage NADPH oxidase flavocytochrome b558.

Casbon AJ, Long ME, Dunn KW, Allen LA, Dinauer MC.SourceHerman B Wells Center for Pediatric Research, Department of Pediatrics (Hematology/Oncology), James Whitcomb Riley Hospital for Children and Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Journal of leukocyte biology.J Leukoc Biol.2012 Oct;92(4):869-82. doi: 10.1189/jlb.0512244. Epub 2012 Jul 20.
Flavocytochrome b(558), the catalytic core of the phagocyte NADPH oxidase (NOX2), mediates electron transfer from NADPH to molecular oxygen to generate superoxide, the precursor of highly ROS for host defense. Flavocytochrome b(558) is an integral membrane heterodimer consisting of a large glycosyla
PMID 22822009

Anionic lipid-induced conformational changes in human phagocyte flavocytochrome b precede assembly and activation of the NADPH oxidase complex.

Taylor RM, Riesselman MH, Lord CI, Gripentrog JM, Jesaitis AJ.SourceDepartment of Microbiology, 109 Lewis Hall, Montana State University, Bozeman, MT 59717, USA.
Archives of biochemistry and biophysics.Arch Biochem Biophys.2012 May;521(1-2):24-31. doi: 10.1016/j.abb.2012.01.018. Epub 2012 Mar 10.
Phagocyte NADPH oxidases generate superoxide at high rates in defense against infectious agents, a process regulated by second messenger anionic lipids using incompletely understood mechanisms. We reconstituted the catalytic core of the human neutrophil NADPH oxidase, flavocytochrome b (Cyt b) in 99
PMID 22430035