UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. エーリキアの生物学 biology of ehrlichiae
2. 貧食細胞機能の原発性疾患：概要 primary disorders of phagocytic function an overview
3. 慢性肉芽腫性疾患：病因、臨床症状、および診断 chronic granulomatous disease pathogenesis clinical manifestations and diagnosis

English Journal

Curcumin and resveratrol act by different ways on NADPH oxidase activity and reactive oxygen species produced by equine neutrophils.

Derochette S, Franck T, Mouithys-Mickalad A, Ceusters J, Deby-Dupont G, Lejeune JP, Neven P, Serteyn D.SourceCenter for Oxygen, R&D (CORD), Institute of Chemistry, B6a, University of Liège, Allée de la Chimie 3, B-4000 Liège, Belgium. Electronic address: sderochette@ulg.ac.be.
Chemico-biological interactions.Chem Biol Interact.2013 Nov 25;206(2):186-93. doi: 10.1016/j.cbi.2013.09.011. Epub 2013 Sep 20.
In neutrophils (PMNs), superoxide anion (O2(-)), the first reactive oxygen species (ROS) produced to kill pathogenic agents, is generated by NADPH oxidase, an enzymatic complex formed by the translocation of cytosolic subunits to the membrane flavocytochrome b558. In horses, excessive activation of
PMID 24060679

The TLR7/8 agonist CL097 primes N-formyl-methionyl-leucyl-phenylalanine-stimulated NADPH oxidase activation in human neutrophils: critical role of p47phox phosphorylation and the proline isomerase Pin1.

Makni-Maalej K, Boussetta T, Hurtado-Nedelec M, Belambri SA, Gougerot-Pocidalo MA, El-Benna J.SourceINSERM, U773, Centre de Recherche Biomédicale Bichat Beaujon, Paris F-75018, France.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2012 Nov 1;189(9):4657-65. doi: 10.4049/jimmunol.1201007. Epub 2012 Sep 21.
Superoxide anion production by the neutrophil NADPH oxidase plays a key role in host defense; however, excessive superoxide production is believed to participate to inflammatory reactions. Neutrophils express several TLR that recognize a variety of microbial motifs or agonists. The interaction betwe
PMID 23002436

Effects of IFN-γ on intracellular trafficking and activity of macrophage NADPH oxidase flavocytochrome b558.

Casbon AJ, Long ME, Dunn KW, Allen LA, Dinauer MC.SourceHerman B Wells Center for Pediatric Research, Department of Pediatrics (Hematology/Oncology), James Whitcomb Riley Hospital for Children and Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Journal of leukocyte biology.J Leukoc Biol.2012 Oct;92(4):869-82. doi: 10.1189/jlb.0512244. Epub 2012 Jul 20.
Flavocytochrome b(558), the catalytic core of the phagocyte NADPH oxidase (NOX2), mediates electron transfer from NADPH to molecular oxygen to generate superoxide, the precursor of highly ROS for host defense. Flavocytochrome b(558) is an integral membrane heterodimer consisting of a large glycosyla
PMID 22822009

岡村美湖,遠藤彰,吉川俊輔,森尾友宏
日本臨床免疫学会会誌 37(4), 360a-360a, 2014
… に関連する指標に関して健常者の好中球と同時に解析し，重症度との関連性を検討した．表面抗原としては，好中球の遊走を制御する因子とされるCXCR2，PILRalpha，活性酸素産生の指標とされるFlavocytochrome b558を解析した結果，患者好中球の遊走能・活性酸素産生能に明らかに健常者との差が認められた．刺激物質による活性酸素種の測定でも患者好中球がプライミング状態であり活性酸素産生能が高 …
NAID 130004694287