clobazam

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/04/25 15:54:20」(JST)

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英文文献

  • Budget impact analysis of antiepileptic drugs for lennox-gastaut syndrome.
  • Skornicki M1, Clements KM, O'Sullivan AK.Author information 1OptumInsight, 10 Cabot Rd., Ste. 304, Medford, MA 02155, USA. michelle.skornicki@gmail.com.AbstractBACKGROUND: In October 2011, clobazam was FDA-approved for adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS), a debilitating childhood epilepsy characterized by drop attacks, for patients 
2 years and older. 
  • Journal of managed care pharmacy : JMCP.J Manag Care Pharm.2014 Apr;20(4):400-6.
  • BACKGROUND: In October 2011, clobazam was FDA-approved for adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS), a debilitating childhood epilepsy characterized by drop attacks, for patients 
2 years and older. OBJECTIVE: To assess the budget impact of adding clobazam to
  • PMID 24684645
  • Stable dosages of clobazam for Lennox-Gastaut syndrome are associated with sustained drop-seizure and total-seizure improvements over 3 years.
  • Conry JA1, Ng YT, Kernitsky L, Mitchell WG, Veidemanis R, Drummond R, Isojarvi J, Lee D, Paolicchi JM; The OV-1004 Study Investigators.Author information 1Children's National Medical Center, Washington, District of Columbia, U.S.A.AbstractOBJECTIVE: To determine long-term safety and efficacy of adjunctive clobazam for patients with Lennox-Gastaut syndrome (LGS).
  • Epilepsia.Epilepsia.2014 Mar 1. doi: 10.1111/epi.12561. [Epub ahead of print]
  • OBJECTIVE: To determine long-term safety and efficacy of adjunctive clobazam for patients with Lennox-Gastaut syndrome (LGS).METHODS: Eligible patients from two randomized controlled trials (Phase II OV-1002 and Phase III OV-1012) were able to enroll in open-label extension (OLE) study OV-1004 begin
  • PMID 24580023
  • Effectiveness of add-on stiripentol to clobazam and valproate in Japanese patients with Dravet syndrome: Additional supportive evidence.
  • Inoue Y1, Ohtsuka Y2; STP-1 Study Group.Author information 1National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Urushiyama 886, Aoi-ku, Shizuoka 420-8688, Japan. Electronic address: yinoue-jes@umin.net.2Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.AbstractPURPOSE: To evaluate the efficacy and safety of stiripentol as add-on therapy in Japanese patients with Dravet syndrome treated with clobazam (CLB) and valproate (VPA).
  • Epilepsy research.Epilepsy Res.2014 Feb 19. pii: S0920-1211(14)00048-5. doi: 10.1016/j.eplepsyres.2014.02.008. [Epub ahead of print]
  • PURPOSE: To evaluate the efficacy and safety of stiripentol as add-on therapy in Japanese patients with Dravet syndrome treated with clobazam (CLB) and valproate (VPA).METHODS: In this open-label study, patients aged 1-30 years entered a 4-week baseline phase, followed by a 4-week stiripentol dose-a
  • PMID 24630050

和文文献

  • Impact of P-glycoprotein and breast cancer resistance protein on the brain distribution of antiepileptic drugs in knockout mouse models.
  • Nakanishi Haruka,Yonezawa Atsushi,Matsubara Kazuo,Yano Ikuko
  • European journal of pharmacology 710(1-3), 20-28, 2013-06-15
  • … In contrast, the Kpbrain values of phenobarbital, clobazam, zonisamide, gabapentin, tiagabine, and levetiracetam in the Mdr1a/1b(-/-)/Bcrp(-/-) mice were significantly higher than the corresponding ones in Mdr1a/1b(-/-) mice. …
  • NAID 120005289852
  • 臨床研究・症例報告 N-desmethylclobazam濃度高値により眼瞼下垂,構音障害を呈した1例
  • 松浦 隆樹,浜野 晋一郎,大場 温子 [他]
  • 小児科臨床 66(5), 953-958, 2013-05
  • NAID 40019634479
  • Panayiotopoulos症候群に有効な抗てんかん薬についての後方視的検討
  • 平野 嘉子,小国 弘量,大澤 眞木子,HIRANO Yoshiko,OGUNI Hirokazu,OSAWA Makiko
  • 東京女子医科大学雑誌 83(E1), E65-E68, 2013-01-31
  • … 使用していた抗てんかん薬は平均3剤であり、なかでもバルプロ酸ナトリウム(Sodium valproate : VPA)、カルバマゼピン(Carbamazepine : CBZ)クロバザム(Clobazam : CLB)の3剤は有効で長期使用可能であった。 …
  • NAID 110009559392

関連リンク

Clobazam may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: tiredness problems with coordination difficulty speaking or swallowing drooling change in appetite vomiting
When is clobazam used ? Clobazam belongs to a class of medications called benzodiazepines (BEN-zo-di-AZ-ah-peens). Clobazam is effective against all seizure types, although tolerance (lessening of the effect from the same dose ...

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Onfi (Clobazam) - Treatment for Lennox FDA warns that anti-seizure drug Onfi can ClobazamFrisium (Clobazam) 10mg by Sanofi Aventis Clobazam has the following structural Clobazam


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