clearance of drugs

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  • (177)Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment.
  • Bergmann R1, Meckel M2, Kubíček V3, Pietzsch J1, Steinbach J1, Hermann P3, Rösch F4.
  • EJNMMI research.EJNMMI Res.2016 Dec;6(1):5. doi: 10.1186/s13550-016-0161-3. Epub 2016 Jan 16.
  • BACKGROUND: Metastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression, and pathological fracture, associated with an obvious morbidity. Common treatments including systemic application of bisphosphonate drugs a
  • PMID 26780082
  • The pharmacokinetics change of cefepime after Shuanghuanglian injection administration in subjects with the renal damage.
  • Chen H1, Min J1, Li W1, Zhao W1, Mi S1, Wang N1, Zhu C1.
  • Drug and chemical toxicology.Drug Chem Toxicol.2016 Apr;39(2):129-36. doi: 10.3109/01480545.2015.1053565. Epub 2015 Jun 25.
  • Shuanghuanglian injection (SHLI) has been widely used for administration with cephalosporin in China for long time. The objective of this study was to evaluate the pharmacological properties and biochemical changes of cefepime combined with SHLI. The SD rats included were received either an intraven
  • PMID 26108148
  • Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain.
  • Cevey ÁC1, Mirkin GA1, Penas FN1, Goren NB1.
  • International journal for parasitology. Drugs and drug resistance.Int J Parasitol Drugs Drug Resist.2015 Dec 12;6(1):12-22. doi: 10.1016/j.ijpddr.2015.12.001. eCollection 2016.
  • Chagas disease, caused by Trypanosoma cruzi, is the main cause of dilated cardiomyopathy in the Americas. Antiparasitic treatment mostly relies on benznidazole (Bzl) due to Nifurtimox shortage or unavailability. Both induce adverse drug effects (ADE) of varied severity in many patients, leading to t
  • PMID 26862474


  • CKDと麻酔関連薬物の薬物動態 (特集 慢性腎臓病(CKD)と麻酔管理)
  • 結合自由エネルギー計算を用いた薬物クリアランス経路予測の改善(機械学習によるバイオデータマインニング,一般)
  • 齊藤 有紀,石田 貴士,関嶋 政和,秋山 泰
  • 電子情報通信学会技術研究報告. NC, ニューロコンピューティング 113(111), 83-88, 2013-06-20
  • 近年,薬剤開発に必要な時間や費用が増大しており,薬剤開発の期間短縮や費用削減が求められている.そのための手法としてコンピュータ上でのシミュレーションを用いて,ターゲットとなるタンパク質を阻害する薬物の構造を設計する手法が注目を浴びている.一方で,薬物として使用する化合物は,体内で代謝・排泄されなければならないという条件がある.この条件を満たす薬物の選定のために行われるのが薬物クリアランス経路予測で …
  • NAID 110009773480
  • Genetic Diversity and Lack of Artemisinin Selection Signature on the Plasmodium falciparum ATP6 in the Greater Mekong Subregion
  • Miao Miao,Wang Zenglei,Yang Zhaoqing,Yuan Lili,Parker Daniel M.,Putaporntip Chaturong,Jongwutiwes Somchai,Xangsayarath Phonepadith,Pongvongsa Tiengkham,Moji Hazuhiko,Dinh Tuong Trinh,Abe Tomoko,Nakazawa Shusuke,Kyaw Myat Phone,Yan Guiyun,Sirichaisinthop Jeeraphat,Sattabongkot Jetsumon,Mu Jianbing,Su Xin-zhuan,Kaneko Osamu,Cui Liwang
  • PLoS ONE 8(3), e59192, 2013-03-26
  • … The recent detection of clinical Artemisinin (ART) resistance manifested as delayed parasite clearance in the Cambodia-Thailand border area raises a serious concern. … The mechanism of ART resistance is not clear; … falciparum sarco/endoplasmic reticulum Ca2+-ATPase (PfSERCA or PfATP6) has been speculated to be the target of ARTs and thus a potential marker for ART resistance. …
  • NAID 120005231335


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1. Clin Pharmacokinet. 1983 Jul-Aug;8(4):286-96. Influence of food intake on presystemic clearance of drugs. Melander A, McLean A. Many drugs have a low degree of oral bioavailability even though their gastrointestinal absorption is ...






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「《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)」


  [★] クリアランス

WordNet   license wordnet

「permission to proceed; "the plane was given clearance to land"」

WordNet   license wordnet

「the distance by which one thing clears another; the space between them」

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「〈U〉〈C〉(…の)取り片付け,除去,掃除《+『of』+『名』》 / 〈U〉〈C〉(積荷の)通関手続き,(船の)出港免状 / (またclearance sale)〈C〉大棚ざらいの売出し / 〈U〉〈C〉(手形の)決済,(小切手の)現金化 / 〈U〉〈C〉(二つの物の間の)あき,余裕;(特に)道路面・川の面から橋げたまでの高さ / 〈U〉〈C〉秘密情報の使用許可;(秘密情報を扱う人の)信頼性調査;公安調査」




WordNet   license wordnet

「use recreational drugs」
do drugs

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「administer a drug to; "They drugged the kidnapped tourist"」

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「a substance that is used as a medicine or narcotic」

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「『薬』,薬品,薬剤 / 『麻薬』,麻酔剤 / 〈人〉‘に'薬(特に麻酔剤)を与える / 〈飲食物〉‘に'(麻酔薬・毒薬などの)薬を混ぜる」



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「OLD French古[代]フランス語」