WordNet

being long-lasting and recurrent or characterized by long suffering; "chronic indigestion"; "a chronic shortage of funds"; "a chronic invalid"
of long duration; "chronic money problems" (同)continuing
habitual; "a chronic smoker" (同)inveterate
a nonmetallic bivalent element that is normally a colorless odorless tasteless nonflammable diatomic gas; constitutes 21 percent of the atmosphere by volume; the most abundant element in the earths crust (同)O, atomic number 8
the physiological state produced by a poison or other toxic substance (同)toxic condition, intoxication
the act of giving poison to a person or animal with the intent to kill

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Molecular mechanisms of ethanol-associated oro-esophageal squamous cell carcinoma.

Liu Y1, Chen H2, Sun Z3, Chen X4.
Cancer letters.Cancer Lett.2015 Jun 1;361(2):164-73. doi: 10.1016/j.canlet.2015.03.006. Epub 2015 Mar 9.
Alcohol drinking is a major etiological factor of oro-esophageal squamous cell carcinoma (OESCC). Both local and systemic effects of ethanol may promote carcinogenesis, especially among chronic alcoholics. However, molecular mechanisms of ethanol-associated OESCC are still not well understood. In th
PMID 25766659

Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid.

Zhang D1, Lee B1, Nutter A1, Song P2, Dolatabadi N1, Parker J1, Sanz-Blasco S1, Newmeyer T1, Ambasudhan R1, McKercher SR1, Masliah E2, Lipton SA1,2.
Journal of neurochemistry.J Neurochem.2015 Jun;133(6):898-908. doi: 10.1111/jnc.13074. Epub 2015 Mar 11.
Cyanide is a life-threatening, bioterrorist agent, preventing cellular respiration by inhibiting cytochrome c oxidase, resulting in cardiopulmonary failure, hypoxic brain injury, and death within minutes. However, even after treatment with various antidotes to protect cytochrome oxidase, cyanide int
PMID 25692407

PPAR-α agonist fenofibrate protects against the damaging effects of MPTP in a rat model of Parkinson's disease.

Barbiero JK1, Santiago R1, Tonin FS1, Boschen S1, da Silva LM1, Werner MF1, da Cunha C1, Lima MM2, Vital MA3.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2014 Aug 4;53:35-44. doi: 10.1016/j.pnpbp.2014.02.009. Epub 2014 Mar 1.
Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The etiology and pathogenesis of PD are still unknown, however, many evidences suggest a prominent role of oxidative stress, inflam
PMID 24593945

一酸化炭素中毒患者における脳ブドウ糖代謝 : ^<18>F-fluorodeoxyglucose(FDG)positron emission tomography(PET)を用いた検討

河井信行,畠山哲宗,黒田泰弘,山下進,西山佳宏,田宮隆,長尾省吾
脳神経外科ジャーナル 15(6), 473-479, 2006-06-20
急性一酸化炭素(CO)中毒の2症例において,PET検査による脳ブドウ糖(GLU)代謝を測定したので報告する.1症例目は15歳の女性で,高気圧酸素療法を施行後直ちに脳循環代謝とGLU代謝をPETにて測定した.明らかな脳血流量の低下は認められなかったが,両側淡蒼球,視床,前頭葉皮質でのGLU代謝の低下を認めた.2症例目は19歳の男性で,保存的に加療し,入院8日目にGLU代謝をPETにて測定し,両側淡蒼 …
NAID 110004732005