chondro-4-sulfatase

• コンドロ-4-スルファターゼ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/03 07:49:45」(JST)

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Chondro-4-sulfatase
Identifiers
EC number	3.1.6.9
CAS number	9045-75-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a chondro-4-sulfatase (EC 3.1.6.9) is an enzyme that catalyzes the chemical reaction

4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate + H₂O 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine + sulfate

The 3 substrates of this enzyme are 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine, 4-sulfate, and H₂O, whereas its two products are 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine and sulfate.

This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name of this enzyme class is 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-su lfate 4-sulfohydrolase. This enzyme is also called chondroitin-4-sulfatase.

References

• Held E, Buddecke E (1967). "[Studies on the chemistry of the arterial wall, XI. Demonstration, purification and properties of a chondroitin-4-sulfatase from bovine aorta]". Hoppe. Seylers. Z. Physiol. Chem. 348 (8): 1047–60. PMID 5595107. 
• Roy AB (1976). "Sulphatases, lysosomes and disease". Aust. J. Exp. Biol. Med. Sci. 54 (2): 111–35. doi:10.1038/icb.1976.13. PMID 13772. 
• Yamagata T, Saito H, Habuchi O, Suzuki S (1968). "Purification and properties of bacterial chondroitinases and chondrosulfatases". J. Biol. Chem. 243 (7): 1523–35. PMID 5647268. 

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English Journal

• Development of a mouse monoclonal antibody against the chondroitin sulfate-protein linkage region derived from shark cartilage.

• Akatsu C, Fongmoon D, Mizumoto S, Jacquinet JC, Kongtawelert P, Yamada S, Sugahara K.SourceLaboratory of Proteoglycan Signaling and Therapeutics, Graduate School of Life Science, Hokkaido University, Frontier Research Center for Post-Genomic Science and Technology, Nishi 11-choume, Kita 21-jo, Kita-ku, Sapporo, Hokkaido, 001-0021, Japan.
• Glycoconjugate journal.Glycoconj J.2010 May;27(4):387-99. doi: 10.1007/s10719-010-9286-1. Epub 2010 Mar 25.
• Glycosaminoglycans (GAGs) like chondroitin sulfate (CS) and heparan sulfate (HS) are synthesized on the tetrasaccharide linkage region, GlcAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser, of proteoglycans. The Xyl can be modified by 2-O-phosphate in both CS and HS, whereas the Gal residues can be sulfate
• PMID 20336366

• Development of a novel analytical method for determination of chondroitin sulfate using an in-capillary enzyme reaction.

• Okamoto H, Nakajima T, Ito Y, Shimada K, Yamato S.SourceAnalytical Laboratory, Taisho Pharmaceutical Co. Ltd., 403 Yoshino-cho 1-chome, Kita-ku, Saitama 331-9530, Japan. h.okamoto@po.rd.taisho.co.jp
• Journal of chromatography. A.J Chromatogr A.2004 Apr 30;1035(1):137-44.
• A novel analytical method for determination of total amount of chondroitin sulfate (CS) based on its conversion to desulfated chondro-disaccharide via an enzyme-catalyzed reaction, was developed. Using the in-capillary enzyme reaction, the method was also applied to the successful construction of an
• PMID 15117083

• Microanalysis of enzyme digests of hyaluronan and chondroitin/dermatan sulfate by fluorophore-assisted carbohydrate electrophoresis (FACE).

• Calabro A, Benavides M, Tammi M, Hascall VC, Midura RJ.SourceDepartment of Biomedical Engineering/ND20, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
• Glycobiology.Glycobiology.2000 Mar;10(3):273-81.
• Hyaluronan and chondroitin/dermatan sulfate are glycosaminoglycans that play major roles in the biomechanical properties of a wide variety of tissues, including cartilage. A chondroitin/dermatan sulfate chain can be divided into three regions: (1) a single linkage region oligosaccharide, through whi
• PMID 10704526

Japanese Journal

• Development of a mouse monoclonal antibody against the chondroitin sulfate-protein linkage region derived from shark cartilage

• Akatsu Chizuru,Fongmoon Duriya,Mizumoto Shuji,Jacquinet Jean-Claude,Kongtawelert Prachya,Yamada Shuhei,Sugahara Kazuyuki
• Glycoconjugate Journal 27(4), 387-399, 2010-05
• … Glycosaminoglycans (GAGs) like chondroitin sulfate (CS) and heparan sulfate (HS) are synthesized on the tetrasaccharide linkage region, GlcAβ1-3Galβ1-3Galβ1-4Xylβ1-O-Ser, of proteoglycans. … The Xyl can be modified by 2-O-phosphate in both CS and HS, whereas the Gal residues can be sulfated at C-4 and/or C-6 in CS but not in HS. … It did not react to the CS linkage region modified by 4-O-sulfation. …
• NAID 120004043736

Related Links

• Chondro-4-Sulfatase - RightDiagnosis.com - Right Diagnosis

Chondro-4-Sulfatase information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Chondro-4-Sulfatase Description of Chondro-4-Sulfatase Chondro-4-Sulfatase: An ...

• Chondro-4-sulfatase: Definition with Chondro-4-sulfatase ...

Medical Definition of Chondro-4-sulfatase 1. An arylsulfatase that catalyses the hydrolysis of the 4-sulfate groups of the disaccharide repeating units from chondroitin sulfate n-acetylgalactosamine 4-sulfate. The deficiency of chondro-4 ...

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