chloride-bicarbonate exchanger

出典: meddic


chloride-bicarbonate antiporterCl- HCO3- exchanger、Cl-HCO3 exchanger

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/02/01 18:49:04」(JST)

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  • Regulation of SLC26A3 activity by NHERF4 PDZ-mediated interaction.
  • Lee JH, Nam JH, Park J, Kang DW, Kim JY, Lee MG, Yoon JS.SourceDepartment of Pharmacology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea.
  • Cellular signalling.Cell Signal.2012 Sep;24(9):1821-30. Epub 2012 May 22.
  • SLC26A3 functions as a chloride/bicarbonate anion exchanger expressed in the secretory epithelial cells in the intestine, pancreas, and salivary glands. SLC26A3 has a C-terminal class I PDZ binding motif that assembles regulatory factors or other transporters by anchoring to various PDZ scaffold pro
  • PMID 22627094
  • Efflux of glutathione and glutathione complexes from human erythrocytes in response to vanadate.
  • Cakir Y, Yildiz D.AbstractThe main objective of the present study was to investigate if vanadate is extruded from the cells in a glutathione dependent manner resulting in the appearance of extracellular glutathione and complexes of glutathione with vanadium. Vanadate significantly depleted intracellular non-protein sulfhydryl (NPSH) levels in a time- and concentration-dependent manner. The intracellular NPSH level was decreased to 0.0±0.0μmol/ml erythrocyte when exposed to 10mM of vanadate for 4h. Extracellular NPSH level was increased concomitantly with the intracellular decrease and reached to 0.1410±0.005μmol/ml erythrocyte in 4h. Intracellular decrease and extracellular increase in NPSH levels were significantly inhibited in the presence of DIDS, a chloride-bicarbonate exchanger which also mediates phosphate and arsenate transport in erythrocytes. In parallel with the increase in extracellular NPSH levels, significant increases in extracellular glutathione levels were detected following exposure to vanadate. Extracellular glutathione levels reached to 0.0150±0.0.001, 0.0330±0.001, and 0.0576±0.002μmol/ml erythrocyte with 1, 5, and 10mM of vanadate respectively. Dimercaptosuccinic acid treatment of supernatants significantly increased the glutathione levels measured in the extracellular media. Utilization of MK571 an MRP inhibitor decreased the rate of glutathione efflux from erythrocytes suggesting a role for this membrane transporter in the process. A known methylation inhibitor periodate oxidized adenosine decreased the rate of glutathione efflux from erythrocytes. This observed decrease in extracellular GSH levels suggests that GSH release partly requires a proper cellular methylation process and that part of GSH detected in the extracellular media may arise from GSH-vandium complexes. The results of the present study indicate that human erythrocyte efflux glutathione in reduced free form and in conjugated form/s that can be recovered with dimercaptosuccinic acid when exposed to vanadate.
  • Blood cells, molecules & diseases.Blood Cells Mol Dis.2012 Jul 22. [Epub ahead of print]
  • The main objective of the present study was to investigate if vanadate is extruded from the cells in a glutathione dependent manner resulting in the appearance of extracellular glutathione and complexes of glutathione with vanadium. Vanadate significantly depleted intracellular non-protein sulfhydry
  • PMID 22824382



Meaning of Chloride-bicarbonate exchanger medical term. What does Chloride-bicarbonate exchanger mean? Chloride-bicarbonate exchanger | definition of Chloride-bicarbonate exchanger by Medical dictionary http://medical ? ...
Abstract Bicarbonate/chloride (HCO − 3 /Cl −) exchangers regulate intracellular pH in the alkaline range. Previously, it has been shown that mouse embryos at the two-cell stage exhibit this activity, but that the otherwise ...



リンク元Cl-/HCO3-交換輸送体」「chloride-bicarbonate antiporter」「塩素イオン・炭酸水素イオン交換輸送体」「Cl- HCO3- exchanger



Cl- HCO3- exchanger、Cl-HCO3 exchanger、chloride-bicarbonate exchangerchloride-bicarbonate antiporter

chloride-bicarbonate antiporter」


chloride-bicarbonate exchangerCl- HCO3- exchanger、Cl-HCO3 exchanger



chloride-bicarbonate exchangerchloride-bicarbonate antiporterCl- HCO3- exchanger

Cl- HCO3- exchanger」


chloride-bicarbonate antiporterchloride-bicarbonate exchanger、Cl-HCO3 exchanger



  • n.
  • v.
  • 交換する

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「hand over one and receive another, approximately equivalent; "exchange prisoners"; "exchange employees between branches of the company"」

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「chemical process in which one atom or ion or group changes places with another」

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「reciprocal transfer of equivalent sums of money (especially the currencies of different countries); "he earns his living from the interchange of currency"」

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「the act of changing one thing for another thing; "Adam was promised immortality in exchange for his disobedience"; "there was an interchange of prisoners"」

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「(chess) gaining (or losing) a rook in return for a knight or bishop; "black lost the exchange"」

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「(chess) the capture by both players (usually on consecutive moves) of pieces of equal value; "the endgame began after the exchange of queens"」

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「a workplace for buying and selling; open only to members」

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「the act of giving something in return for something received; "deductible losses on sales or exchanges of property are allowable"」

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「a mutual expression of views (especially an unpleasant one); "they had a bitter exchange"」

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「…‘を'『取り替える』;(…と)…‘を'取り替える《+『名』+『for』+『名』》 / …‘を'『取り交わす』;(人と)…‘を'取り交わす《+『名』+『with』+『名』〈人〉》 / (化幣が)両替される / 〈U〉〈C〉(物の物との)『取り替え』《+『of』+『名』+『for』+『名』》;(相手と物を)『交換すること』《+『of』+『名』(複数)+『with』+『名』〈人〉》 / 〈C〉交換物,取り替え品 / 〈C〉取引所;(電話の)交換局 / 〈U〉両替;為替(かわせ),為替相場 / 〈C〉=employment exchange」

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「give to, and receive from, one another; "Would you change places with me?"; "We have been exchanging letters for a year"」
change, interchange


  [★] 塩素イオン

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「any compound containing a chlorine atom」

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「any salt of hydrochloric acid (containing the chloride ion)」

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  [★] 重炭酸

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「a salt of carbonic acid (containing the anion HCO3) in which one hydrogen atom has been replaced; an acid carbonate」
hydrogen carbonate

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「one whose business is to exchange the money of one country for that of another country」
money changer