出典: meddic


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「any of a group of proteases that mediate apoptosis」

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  • Regulation of hippocampal Fas receptor and death-inducing signaling complex after kainic acid treatment in mice.
  • Keller B1, García-Sevilla JA2.
  • Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2015 Dec 3;63:54-62. doi: 10.1016/j.pnpbp.2015.04.009. Epub 2015 Jun 2.
  • Kainic acid (KA)-induced brain neuronal cell death (especially in the hippocampus) was shown to be mainly mediated by the intrinsic (mitochondrial) apoptotic pathway. This study investigated the regulation of the extrinsic apoptotic pathway mediated by Fas ligand/Fas receptor and components of the i
  • PMID 26044520
  • NSAID-manufacturing plant effluent induces geno- and cytotoxicity in common carp (Cyprinus carpio).
  • SanJuan-Reyes N1, Gómez-Oliván LM2, Galar-Martínez M3, García-Medina S3, Islas-Flores H1, González-González ED1, Cardoso-Vera JD1, Jiménez-Vargas JM4.
  • The Science of the total environment.Sci Total Environ.2015 Oct 15;530-531:1-10. doi: 10.1016/j.scitotenv.2015.05.088. Epub 2015 May 27.
  • The pharmaceutical industry generates wastewater discharges of varying characteristics and contaminant concentrations depending on the nature of the production process. The main chemicals present in these effluents are solvents, detergents, disinfectants - such as sodium hypochlorite (NaClO) - and p
  • PMID 26026403
  • Guggulsterone and bexarotene induce secretion of exosome-associated breast cancer resistance protein and reduce doxorubicin resistance in MDA-MB-231 cells.
  • Kong JN1, He Q1, Wang G1, Dasgupta S1,2, Dinkins MB1, Zhu G1, Kim A1, Spassieva S3, Bieberich E1.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2015 Oct 1;137(7):1610-20. doi: 10.1002/ijc.29542. Epub 2015 Apr 27.
  • Many breast cancer cells acquire multidrug resistance (MDR) mediated by ABC transporters such as breast cancer resistance protein (BCRP/ABCG2). Here we show that incubation of human breast cancer MDA-MB-231 cells with farnesoid X receptor antagonist guggulsterone (gug) and retinoid X receptor agonis
  • PMID 25833198


  • Carboxylic Derivatives of Vitamin K2 Inhibit Hepatocellular Carcinoma Cell Growth through Caspase/Transglutaminase-Related Signaling Pathways
  • QIN Xian-Yang,FUJII Shinya,SHIMIZU Akitaka [他]
  • Journal of nutritional science and vitaminology 61(4), 285-290, 2015-08
  • NAID 40020570335
  • Apoptosis induction by aluminum phthalocyanine tetrasulfonate-based sonodynamic therapy in HL-60 cells
  • Iwase Yumiko,Yumita Nagahiko,Nishi Koji,Kuwahara Hiroyuki,Fukai Toshio,Ikeda Toshihiko,Chen Fu-shih,Momose Yasunori,Umemura Shin-ichiro
  • Jpn. J. Appl. Phys. 54(7S1), 07HD05, 2015-06-08
  • … Apoptosis was analyzed by cell morphology, DNA fragmentation, and caspase-3 activity. … Furthermore, DNA ladder formation, caspase-3 activation and enhanced nitroxide generation were observed in cells treated with ultrasound and AlPcTS. … Sonodynamically induced apoptosis, caspase-3 activation, and nitroxide generation were significantly suppressed by histidine. …
  • NAID 150000110984
  • プロテアソーム阻害剤およびIMiDsの作用機序研究の進展 (特集 多発性骨髄腫をめぐる最近の進歩と話題)
  • 菊池 次郎,古川 雄祐
  • 血液内科 = Hematology 70(6), 690-697, 2015-06
  • NAID 40020529726


caspaseのcascadeはなかなか複雑で、関連する蛋白質がたくさん登場します。適宜解説を加えてくれているのでたすかりますが、理解を深めるために、重要なタンパク質 (たとえば、 BclやIAPファミリーなど)について、リンクを ...
アポトーシス検出(発光:カスパーゼ-3/7、8、9、2、6) Caspase-Glo Assays* 製品説明 Caspase-Glo ® Assaysは、各種カスパーゼ活性を測定するためのホモジニアスフォーマット発光アッセイシステムです。本アッセイでは、プロテアーゼ ...



拡張検索initiator caspase



ICEファミリープロテアーゼ ICE family protease


Family Caspase Other Name Recognition Target (Truncation site)
caspase-1 caspase-1 ICE WEHD pro IL-1β (FEAD/G, YVHD/A), procaspase-3, procaspase-4
caspase-4 ICErel-II, TX, ICH-2  
caspase-5 ICErel-III, TY  
caspase-2 caspase-2 ICH-1 DEHD PARP (DEVD/G)
caspase-9 ICE-LAP6, Mch6 LEHD PARP, procaspase-3
caspase-3 caspase-3 CPP32, Yama DEVD PARP, SREBP (DEPD/S), U1snRNP (DGPD/G), lamin B, D4-GDI (DELD/S), DNA-PK (DEVD/N), DFF (DETD/S, DAVD/T), actin (ELPD/G) ?, PKCδ (DMQD/N) ?]]
caspase-7 Mch3, ICE-LAP3, CMH-1 DEVD PARP, procaspase-6
caspase-6 Mch2 VEHD lamin A (VEID/N)]]
caspase-8 FLICE, MACH, Mch5 LETD procaspase-3, Bid
caspase-10 Mch4 LEXD  
caspase-11 Ich3    




initiator caspase」



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