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- 1. 妊娠に対する母体の心血管系および血行動態の適応 maternal cardiovascular and hemodynamic adaptations to pregnancy
- 2. 心血管MRIの臨床的有用性 clinical utility of cardiovascular magnetic resonance imaging
- 3. BおよびTリンパ球の正常な発生 normal b and t lymphocyte development
- 4. ニコチンの心血管系への影響 cardiovascular effects of nicotine
- 5. 肥満、体重減少、および心血管疾患 obesity weight reduction and cardiovascular disease
- Analysis of beat fluctuations and oxygen consumption in cardiomyocytes by scanning electrochemical microscopy.
- Hirano Y1, Kodama M1, Shibuya M2, Maki Y2, Komatsu Y3.Author information 1Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology, Toyohira, Sapporo 062-8517, Japan.2Cosmo Bio Co., Ltd., Nishi-Ku, Sapporo, Japan.3Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology, Toyohira, Sapporo 062-8517, Japan. Electronic address: email@example.com.AbstractThe contractile behavior of cardiomyocytes can be monitored by measuring their action potentials, and the analysis is essential for screening the safety of potential drugs. However, immobilizing cardiac cells on a specific electrode is considerably complicated. In this study, we demonstrate that scanning electrochemical microscopy (SECM) can be used to analyze rapid topographic changes in beating cardiomyocytes in a standard culture dish. Various cardiomyocyte contraction parameters and oxygen consumption based on cell respiration could be determined from SECM data. We also confirmed that cellular changes induced by adding the cardiotonic agent digoxin were conveniently monitored by this SECM system. These results show that SECM can be a potentially powerful tool for use in drug development for cardiovascular diseases.
- Analytical biochemistry.Anal Biochem.2014 Feb 15;447:39-42. doi: 10.1016/j.ab.2013.11.008. Epub 2013 Nov 16.
- The contractile behavior of cardiomyocytes can be monitored by measuring their action potentials, and the analysis is essential for screening the safety of potential drugs. However, immobilizing cardiac cells on a specific electrode is considerably complicated. In this study, we demonstrate that sca
- PMID 24252541
- Physical (in)activity-dependent structural plasticity in bulbospinal catecholaminergic neurons of rat rostral ventrolateral medulla.
- Mischel NA, Llewellyn-Smith IJ, Mueller PJ.Author information Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, 48201.AbstractIncreased activity of the sympathetic nervous system is thought to play a role in the development and progression of cardiovascular disease. Recent work has shown that physical inactivity versus activity alters neuronal structure in brain regions associated with cardiovascular regulation. Our physiological studies suggest that neurons in the rostral ventrolateral medulla (RVLM) are more responsive to excitation in sedentary versus physically active animals. We hypothesized that enhanced functional responses in the RVLM may be due, in part, to changes in the structure of RVLM neurons that control sympathetic activity. We used retrograde tracing and immunohistochemistry for tyrosine hydroxylase (TH) to identify bulbospinal catecholaminergic (C1) neurons in sedentary and active rats after chronic voluntary wheel-running exercise. We then digitally reconstructed their cell bodies and dendrites at different rostrocaudal levels. The dendritic arbors of spinally projecting TH neurons from sedentary rats were more branched than those of physically active rats (P < 0.05). In sedentary rats, dendritic branching was greater in more rostral versus more caudal bulbospinal C1 neurons, whereas, in physically active rats, dendritic branching was consistent throughout the RVLM. In contrast, cell body size and the number of primary dendrites did not differ between active and inactive animals. We suggest that these structural changes provide an anatomical underpinning for the functional differences observed in our in vivo studies. These inactivity-related structural and functional changes may enhance the overall sensitivity of RVLM neurons to excitatory stimuli and contribute to an increased risk of cardiovascular disease in sedentary individuals. J. Comp. Neurol. 522:499-513, 2014. © 2013 Wiley Periodicals, Inc.
- The Journal of comparative neurology.J Comp Neurol.2014 Feb 15;522(3):Spc1. doi: 10.1002/cne.23516.
- Increased activity of the sympathetic nervous system is thought to play a role in the development and progression of cardiovascular disease. Recent work has shown that physical inactivity versus activity alters neuronal structure in brain regions associated with cardiovascular regulation. Our physio
- PMID 24374612
- Cohort Profile: The Fangshan Cohort Study of Cardiovascular Epidemiology in Beijing, China
- Wu Na,Tang Xun,Wu Yiqun,Qin Xueying,He Liu,Wang Jinwei,Li Na,Li Jingrong,Zhang Zongxin,Dou Huidong,Liu Jianjiang,Yu Liping,Xu Haitao,Zhang Jianguo,Hu Yonghua,Iso Hiroyasu
- Journal of Epidemiology, 2014
- … Background: Urbanizing rural areas in China face a rapidly growing cardiovascular disease burden. … The baseline examination included a questionnaire on medical history, health knowledge, and behaviors related to cardiovascular disease, as well as physical and blood biochemical examinations. …
- NAID 130003383372
- 榊原 雅人,及川 欧,Lehrer Paul
- バイオフィードバック研究 40(2), 41-48, 2013-10-25
- 本稿は第41回日本バイオフィードバック学会学術総会にて開催された特別企画ワークショップ「心拍変動バイオフィードバック法」の内容をまとめたものである。心拍変動バイオフィードバック(以下,HRV-BF)は,約0.1Hzの緩徐な呼吸を伴う技法で心拍数,血圧,血管緊張に大きな変動を引き起こすと考えられている.この頻度でペース呼吸を行うと,心拍変動の高周波成分と低周波成分は互いに協調し,呼吸性不整脈と圧反射 …
- NAID 110009661879
- Cardiovascular Links: Fetal Blood Flow values | Mean Fetal Blood Flow | Proportions Ventricular Output | Ventricular Output (colour) | Blood Development | Cardiovascular System Development References ↑ Anita Krishnan, Rajeev ...
- Click here to launch the Simbryo Cardiovascular Development animation (and some really trippy music -you'll understand once the window opens...) I. Development of the Heart A. Generation and fusion of the developing heart tubes ...
- system of rules