cardiovascular system development

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英文文献

  • Analysis of beat fluctuations and oxygen consumption in cardiomyocytes by scanning electrochemical microscopy.
  • Hirano Y1, Kodama M1, Shibuya M2, Maki Y2, Komatsu Y3.Author information 1Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology, Toyohira, Sapporo 062-8517, Japan.2Cosmo Bio Co., Ltd., Nishi-Ku, Sapporo, Japan.3Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology, Toyohira, Sapporo 062-8517, Japan. Electronic address: komatsu-yasuo@aist.go.jp.AbstractThe contractile behavior of cardiomyocytes can be monitored by measuring their action potentials, and the analysis is essential for screening the safety of potential drugs. However, immobilizing cardiac cells on a specific electrode is considerably complicated. In this study, we demonstrate that scanning electrochemical microscopy (SECM) can be used to analyze rapid topographic changes in beating cardiomyocytes in a standard culture dish. Various cardiomyocyte contraction parameters and oxygen consumption based on cell respiration could be determined from SECM data. We also confirmed that cellular changes induced by adding the cardiotonic agent digoxin were conveniently monitored by this SECM system. These results show that SECM can be a potentially powerful tool for use in drug development for cardiovascular diseases.
  • Analytical biochemistry.Anal Biochem.2014 Feb 15;447:39-42. doi: 10.1016/j.ab.2013.11.008. Epub 2013 Nov 16.
  • The contractile behavior of cardiomyocytes can be monitored by measuring their action potentials, and the analysis is essential for screening the safety of potential drugs. However, immobilizing cardiac cells on a specific electrode is considerably complicated. In this study, we demonstrate that sca
  • PMID 24252541
  • Physical (in)activity-dependent structural plasticity in bulbospinal catecholaminergic neurons of rat rostral ventrolateral medulla.
  • Mischel NA, Llewellyn-Smith IJ, Mueller PJ.Author information Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, 48201.AbstractIncreased activity of the sympathetic nervous system is thought to play a role in the development and progression of cardiovascular disease. Recent work has shown that physical inactivity versus activity alters neuronal structure in brain regions associated with cardiovascular regulation. Our physiological studies suggest that neurons in the rostral ventrolateral medulla (RVLM) are more responsive to excitation in sedentary versus physically active animals. We hypothesized that enhanced functional responses in the RVLM may be due, in part, to changes in the structure of RVLM neurons that control sympathetic activity. We used retrograde tracing and immunohistochemistry for tyrosine hydroxylase (TH) to identify bulbospinal catecholaminergic (C1) neurons in sedentary and active rats after chronic voluntary wheel-running exercise. We then digitally reconstructed their cell bodies and dendrites at different rostrocaudal levels. The dendritic arbors of spinally projecting TH neurons from sedentary rats were more branched than those of physically active rats (P < 0.05). In sedentary rats, dendritic branching was greater in more rostral versus more caudal bulbospinal C1 neurons, whereas, in physically active rats, dendritic branching was consistent throughout the RVLM. In contrast, cell body size and the number of primary dendrites did not differ between active and inactive animals. We suggest that these structural changes provide an anatomical underpinning for the functional differences observed in our in vivo studies. These inactivity-related structural and functional changes may enhance the overall sensitivity of RVLM neurons to excitatory stimuli and contribute to an increased risk of cardiovascular disease in sedentary individuals. J. Comp. Neurol. 522:499-513, 2014. © 2013 Wiley Periodicals, Inc.
  • The Journal of comparative neurology.J Comp Neurol.2014 Feb 15;522(3):Spc1. doi: 10.1002/cne.23516.
  • Increased activity of the sympathetic nervous system is thought to play a role in the development and progression of cardiovascular disease. Recent work has shown that physical inactivity versus activity alters neuronal structure in brain regions associated with cardiovascular regulation. Our physio
  • PMID 24374612

和文文献

  • Cohort Profile: The Fangshan Cohort Study of Cardiovascular Epidemiology in Beijing, China
  • Wu Na,Tang Xun,Wu Yiqun,Qin Xueying,He Liu,Wang Jinwei,Li Na,Li Jingrong,Zhang Zongxin,Dou Huidong,Liu Jianjiang,Yu Liping,Xu Haitao,Zhang Jianguo,Hu Yonghua,Iso Hiroyasu
  • Journal of Epidemiology, 2014
  • … Background: Urbanizing rural areas in China face a rapidly growing cardiovascular disease burden. … The baseline examination included a questionnaire on medical history, health knowledge, and behaviors related to cardiovascular disease, as well as physical and blood biochemical examinations. …
  • NAID 130003383372
  • 心拍変動バイオフィードバック法(ワークショップ)
  • 榊原 雅人,及川 欧,Lehrer Paul
  • バイオフィードバック研究 40(2), 41-48, 2013-10-25
  • 本稿は第41回日本バイオフィードバック学会学術総会にて開催された特別企画ワークショップ「心拍変動バイオフィードバック法」の内容をまとめたものである。心拍変動バイオフィードバック(以下,HRV-BF)は,約0.1Hzの緩徐な呼吸を伴う技法で心拍数,血圧,血管緊張に大きな変動を引き起こすと考えられている.この頻度でペース呼吸を行うと,心拍変動の高周波成分と低周波成分は互いに協調し,呼吸性不整脈と圧反射 …
  • NAID 110009661879

関連リンク

Cardiovascular Links: Fetal Blood Flow values | Mean Fetal Blood Flow | Proportions Ventricular Output | Ventricular Output (colour) | Blood Development | Cardiovascular System Development References ↑ Anita Krishnan, Rajeev ...
Click here to launch the Simbryo Cardiovascular Development animation (and some really trippy music -you'll understand once the window opens...) I. Development of the Heart A. Generation and fusion of the developing heart tubes ...

関連画像

Mouse-coronary vessel formation.jpgCardiovascular System - Lymphatic gray473.pngEmbryo renal venous cartoon.jpg


★リンクテーブル★
関連記事development」「system」「cardiovascular

development」

  [★]

  • n.
buildupdeploymentdevelopdevelopmentalemergenceengenderevolutionexpandexploitexploitationgenerategenerationgrowthoccuroccurrenceonsettranspireunfold
growth and development


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「processing a photosensitive material in order to make an image visible; "the development and printing of his pictures took only two hours"」
developing

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「a process in which something passes by degrees to a different stage (especially a more advanced or mature stage); "the development of his ideas took many years"; "the evolution of Greek civilization"; "the slow development of her skill as a writer"」
evolution

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「a state in which things are improving; the result of developing (as in the early part of a game of chess); "after he saw the latest development he changed his mind and became a supporter"; "in chess your should take care of your development before moving your queen"」

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「act of improving by expanding or enlarging or refining; "he congratulated them on their development of a plan to meet the emergency"; "they funded research and development"」

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「(music) the section of a composition or movement (especially in sonata form) where the major musical themes are developed and elaborated」

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「a district that has been developed to serve some purpose; "such land is practical for small park developments"」

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「a recent event that has some relevance for the present situation; "recent developments in Iraq"; "what a revolting development!"」

PrepTutorEJDIC   license prepejdic

「〈U〉〈C〉『発達』,発展,発育,成長;『開発』;進化 / 〈U〉(写真の)現像 / 〈C〉発達(発展)の結果できたもの / 〈C〉開発した土地(地区);(特に)住宅団地(housing development) / 〈C〉(最近の)でき事,新事実」


system」

  [★]

  • n.
methodseriesstrain


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「(physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide"」

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「a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going"」
scheme

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「a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender"」
system of rules

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「a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion"」

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「a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation"」

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「the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system"」

PrepTutorEJDIC   license prepejdic

「〈C〉(関連した部分から成る)『体系』,系統,組織[網],装置 / 〈C〉(教育・政治などの)『制度』,機構;《the~》体制 / 〈C〉(思想・学問などの)『体系』,学説 / 〈C〉(…の)『方法』,方式,やり方《+of doing》 / 〈U〉正しい方針(筋道,順序) / 〈U〉《the~》(身体の)組織,系統 / 〈U〉《the~,one's~》身体,全身」

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「instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer"」


cardiovascular」

  [★]

  • adj.
  • 心血管の、心血管系の、循環器の、循環器系の、心血管性の
cardiovascular systemcirculatory system

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「of or pertaining to or involving the heart and blood vessels; "cardiovascular conditioning"」

PrepTutorEJDIC   license prepejdic

「心臓と血管の(に影響する)」




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