出典: meddic


Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/05 22:28:06」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.


  • Autophagy switches to apoptosis in prostate cancer cells infected with melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24).
  • Bhutia SK, Das SK, Azab B, Dash R, Su ZZ, Lee SG, Dent P, Curiel DT, Sarkar D, Fisher PB.SourceDepartment of Human and Molecular Genetics; Virginia Commonwealth University School of Medicine; Richmond, VA USA; Department of Life Science; National Institute of Technology; Rourkela, Orissa India.
  • Autophagy.Autophagy.2011 Sep 1;7(9). [Epub ahead of print]
  • MDA-7/IL-24 has noteworthy potential as an anticancer therapeutic because of its diversity of antitumor properties, its lack of toxicity toward normal cells and tissues, and its safety and efficacy as evidenced in a phase I clinical trial. In a recent study, we document that Ad.mda-7-induced ER stre
  • PMID 21610321
  • Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease.
  • Sagredo O, Pazos MR, Satta V, Ramos JA, Pertwee RG, Fernandez-Ruiz J.SourceDepartamento de Bioquimica y Biologia Molecular, Instituto Universitario de Investigacion en Neuroquimica, Universidad Complutense, Madrid, Spain; Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universidad Complutense, Madrid, Spain; Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), Facultad de Medicina, Universidad Complutense, Madrid, Spain.
  • Journal of neuroscience research.J Neurosci Res.2011 Sep;89(9):1509-18. doi: 10.1002/jnr.22682. Epub 2011 Jun 14.
  • We studied whether combinations of botanical extracts enriched in either Δ(9) -tetrahydrocannabinol (Δ(9) -THC) or cannabidiol (CBD), which are the main constituents of the cannabis-based medicine Sativex, provide neuroprotection in rat models of Huntington's disease (HD). We used rats intoxicated
  • PMID 21674569


  • 胃粘膜防御に果たすカルパインの役割 (特集 NSAIDs潰瘍--最新の予防・治療) -- (特論)
  • 秦 勝志,反町 洋之
  • 日本臨床 69(6), 1116-1122, 2011-06
  • NAID 40018850039
  • 脳虚血による神経細胞死における恒常的活性型カルシニューリンの機能的役割
  • 塩田 倫史,福永 浩司
  • YAKUGAKU ZASSHI 131(1), 13-20, 2011
  • … In a mouse middle cerebral artery occlusion (MCAO) model, calpain, a Ca2+-dependent cysteine protease, converted CaN to the constitutively active form of 48 kDa in vivo. … The calpain-induced CaN activation mediated delayed neuronal death through translocation of nuclear factor of activated T-cells (NFAT) and FKHR, a forkhead box class O family member (FOXO) into neuronal nuclei after brain ischemia. …
  • NAID 130000451520


A calpain is a protein belonging to the family of calcium-dependent, non- lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan ...



拡張検索calpain subunit



カルシウム依存性中性プロテアーゼ calcium dependent neutral protease CDNP, calcium-activated neutral protease
  • プロセシングに関与するシステインプロテアーゼの一種

calpain subunit」

  [★] カルパインサブユニット

"" より作成