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1. 大顆粒T細胞リンパ球性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of t cell large granular lymphocyte leukemia
2. 2型糖尿病の病因 pathogenesis of type 2 diabetes mellitus
3. 男性における続発性性腺機能低下の原因 causes of secondary hypogonadism in males
4. 血小板生物学 platelet biology
5. 肢帯型筋ジストロフィー limb girdle muscular dystrophy

English Journal

Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/β-catenin pathway.

Wang E1, Wang D2, Li B3, Ma H2, Wang C2, Guan L4, Zhang H5, Yi L5, Li S1.
Oncology reports.Oncol Rep.2017 Jan;37(1):379-387. doi: 10.3892/or.2016.5247. Epub 2016 Nov 15.
Melanoma, as one of the most highly metastatic types of cancer, is resistant to current treatment methods, including popular targeted molecular therapy. Consequently, it is essential to develop a deeper understanding of the mechanisms involved in melanoma progression so that alternative treatments m
PMID 27878263

Effect of protein S-nitrosylation on autolysis and catalytic ability of μ-calpain.

Liu R1, Li Y1, Wang M1, Zhou G1, Zhang W2.
Food chemistry.Food Chem.2016 Dec 15;213:470-7. doi: 10.1016/j.foodchem.2016.06.104. Epub 2016 Jun 30.
The effect of S-nitrosylation on the autolysis and catalytic ability of μ-calpain in vitro in the presence of 50μM Ca(2 +) was investigated. μ-Calpain was incubated with different concentrations of nitric oxide donor S-nitrosoglutathione (GSNO) and subsequently reacted with purified myofibrils. R
PMID 27451206

Sequential cleavage of insulin receptor by calpain 2 and γ-secretase impairs insulin signalling.

Yuasa T1,2, Amo-Shiinoki K3,4, Ishikura S3,5, Takahara M6,7, Matsuoka T6, Kaneto H6,8, Kuroda A9,10, Matsuhisa M9,10, Hashida S11.
Diabetologia.Diabetologia.2016 Dec;59(12):2711-2721. Epub 2016 Sep 30.
AIMS/HYPOTHESIS: Soluble insulin receptor (sIR), the ectodomain of the insulin receptor (IR), has been detected in human plasma and its concentration paralleled that of blood glucose. We have previously developed an in vitro model using HepG2 liver-derived cells, which mimics changes in sIR levels i
PMID 27695899

Effects of Insulin-Like Growth Factor-Ⅰ on the Expression of Atrogin-1/MAFbx in Chick Myotube Cultures

Effects of Fasting and Refeeding on Expression of Atrogin-1/MAFbx in Cardiac Muscle of Broiler Chickens

Effects of Fasting and Refeeding on Expression of Atrogin-1/MAFbx in Cardiac Muscle of Broiler Chickens