calcium channel antagonist

出典: meddic

カルシウム拮抗薬 = カルシウムチャネル遮断薬カルシウムチャネル拮抗薬カルシウムチャネル阻害薬Ca antagonistcalcium antagonistcalcium blocker

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/14 13:36:40」(JST)

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  • Treatment of Vascular Cognitive Impairment.
  • Ritter A1, Pillai JA.
  • Current treatment options in neurology.Curr Treat Options Neurol.2015 Aug;17(8):367. doi: 10.1007/s11940-015-0367-0.
  • OPINION STATEMENT: Cerebrovascular disease (CVD) is an important cause of cognitive dysfunction and dementia. The term vascular cognitive impairment (VCI) is used to describe the entire spectrum of cognitive dysfunction-ranging from mild impairment to dementia-attributable to all forms of cerebrovas
  • PMID 26094078
  • Levetiracetam, Calcium Antagonism, and Bipolar Disorder.
  • Dubovsky SL1, Daurignac E, Leonard KE, Serotte JC.
  • Journal of clinical psychopharmacology.J Clin Psychopharmacol.2015 Aug;35(4):422-7. doi: 10.1097/JCP.0000000000000343.
  • Hyperactive intracellular calcium ion (Ca) signaling in peripheral cells has been a reliable finding in bipolar disorder. Some established mood stabilizing medications, such as lithium and carbamazepine, have been found to normalize elevated intracellular Ca concentrations ([Ca]i) in platelets and l
  • PMID 26050018
  • TRPV1 modulators: Synthesis and in vitro evaluation of 1-heteroaryl piperidinecarboxamide and piperazinylurea derivatives.
  • Congiu C1, Onnis V2, Balboni G2, Schiano-Moriello A3, Di Marzo V3, De Petrocellis L3.
  • European journal of medicinal chemistry.Eur J Med Chem.2015 Jul 15;100:129-38. doi: 10.1016/j.ejmech.2015.05.041. Epub 2015 Jun 6.
  • A series of new 1-heteroaryl piperidinecarboxamide and piperazinylurea derivatives was synthesized and evaluated as TRPV1 modulators in a Ca(2+) channel assay in HEK-293 cells overexpressing the human recombinant TRPV1 channel. Structural variations in the putative key portions of the molecules affo
  • PMID 26079089


  • Adjuvant Effect of an Alternative Plasticizer, Diisopropyl Adipate, on a Contact Hypersensitivity Mouse Model: Link with Sensory Ion Channel TRPA1 Activation
  • Kurohane Kohta,Kimura Ayako,Terasawa Rie [他],Sahara Yurina,Kobayashi Kamiyu,Suzuki Wakana,Matsuoka Takeshi,Watanabe Tatsuo,Imai Yasuyuki
  • Biological and Pharmaceutical Bulletin 38(7), 1054-1062, 2015
  • … Activation of TRPA1 by DIA was demonstrated by calcium mobilization using Chinese hamster ovary cells expressing TRPA1 in vitro. … The effect of DIA was inhibited by a TRPA1-specific antagonist, HC-030031. …
  • NAID 130005086278
  • Adjuvant effect of an alternative plasticizer, diisopropyl adipate, on a contact hypersensitivity mouse model: link with sensory ion channel TRPA1 activation
  • Kurohane Kohta,Kimura Ayako,Terasawa Rie,Sahara Yurina,Kobayashi Kamiyu,Suzuki Wakana,Matsuoka Takeshi,Watanabe Tatsuo,Imai Yasuyuki
  • Biological and Pharmaceutical Bulletin advpub(0), 2015
  • … Activation of TRPA1 by DIA was demonstrated by calcium mobilization using Chinese hamster ovary cells expressing TRPA1 in vitro. … The effect of DIA was inhibited by a TRPA1-specific antagonist, HC-030031. …
  • NAID 130005068107
  • 海馬歯状回顆粒細胞における樹状突起周辺の入力統合
  • 上條 中庸,早川 博章,福島 康弘 [他],窪田 芳之,磯村 宜和,塚田 稔,相原 威
  • 電子情報通信学会技術研究報告. NC, ニューロコンピューティング 113(500), 1-4, 2014-03-10
  • 海馬歯状回顆粒細胞の樹伏突起は錐体細胞の特性とは異なることが報告されている.例えば、錐体細胞で起こるような樹状突起スパイクの様な非線形な情報伝達は顆粒細胞にはなく線形な情報処理が行われている.しかし、顆粒細胞の樹状突起の詳細な入力統合メカニズムに関しては知られていない.本研究では樹状突起分岐周辺に着目し、時空間的に異なる入力がどの様に処理されているのかを高速グルタメートアンケージング刺激によって調 …
  • NAID 110009862323


A calcium channel blocker (CCB) is a chemical that disrupts the movement of calcium (Ca2+) through calcium channels. CCB drugs devised to target neurons are used as antiepileptics. However, the most widespread clinical usage of calcium ...
Establishes the medication calcium channel blockers (CCBs), which are drugs used for treating high blood pressure, angina, and abnormal heart rhythms like atrial fibrillation.


Calcium Channels, L-Type; Dihydropyridine Calcium channel blockers | Physiology calcium antagonist nursing mnemonics Calcium; Receptors, Calcium ChannelClinical Use of Calcium Channel Antagonist  -activated calcium channels in glucose

先読みカルシウム拮抗薬」「calcium blocker」「Ca antagonist」「calcium antagonist」「カルシウムチャネル拮抗薬
関連記事channel」「antagonist」「calcium」「channels」「calcium channel



calcium antagonist
カルシウムチャネル遮断薬 calcium channel blocker CCB calcium channel blockers CCBs, Ca2+ channel blockerカルシウムチャネル拮抗薬カルシウムチャネル阻害薬カルシウムチャネルブロッカー
カルシウムブロッカー, calcium blocker, Ca blockerカルシウム拮抗薬カルシウム阻害薬Ca拮抗薬


  • 細胞膜の膜電位依存性Caチャネルに特異的に結合し、細胞内へのカルシウムの流入を減少させる作用を有する薬物の総称。



  • 第1世代
ベラパミル  verapamil  心臓
ジルチアゼム diltiazem  心臓 血管
ニフェジピン nifedipine    血管
  • 第2世代
  • 徐放化的製剤 ・・・剤形が変わる
  • 組織特異性・長時間作用
  • 第3世代 ↓
  • 生物学的利用能↑。血中半減期が長い
アムロジピン amlodipine


  • 1. 末梢血管拡張作用による頭痛、顔面紅潮、めまい
  • 2. 不整脈
  • ジルチアゼム、ベラパミル → 洞性徐脈、房室伝導障害
  • ニフェジピン → 反射性頻脈
  • 3. 下腿浮腫  ←  細静脈拡張せずに細動脈が拡張するため
  • 4. 歯肉肥厚


  • 動物実験にて催奇形性がある→妊婦への使用は禁忌→胎児の形成が終わればO.K.

calcium blocker」


Ca antagonistCa blockercalcium antagonistcalcium channel blocker

Ca antagonist」


Ca blockercalcium antagonistcalcium blockercalcium channel blocker

calcium antagonist」

  [★] カルシウム拮抗薬


  [★] カルシウム拮抗薬



  • n.
  • 川床、川底。水路、河道
  • 海峡
  • 水管、導管
  • 経路、ルート。道筋、方向
ion channelionic channel

WordNet   license wordnet

「direct the flow of; "channel information towards a broad audience"」
canalize, canalise

WordNet   license wordnet

「a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels"」
television channel, TV channel

WordNet   license wordnet

「a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"」

WordNet   license wordnet

「(often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms"」
communication channel, line

WordNet   license wordnet

「a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company"」
transmission channel

WordNet   license wordnet

「a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"」

PrepTutorEJDIC   license prepejdic

「〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す」


  [★] 拮抗薬

WordNet   license wordnet

「a drug that neutralizes or counteracts the effects of another drug」

WordNet   license wordnet

「a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"」

PrepTutorEJDIC   license prepejdic




WordNet   license wordnet

「a white metallic element that burns with a brilliant light; the fifth most abundant element in the earth''s crust; an important component of most plants and animals」
Ca, atomic number 20

PrepTutorEJDIC   license prepejdic



  [★] チャネル

WordNet   license wordnet

「official routes of communication; "you have to go through channels"」

calcium channel」

  [★] カルシウムチャネル