cGMP-dependent protein kinase

出典: meddic

cyclic GMP-dependent protein kinaseG-kinaseprotein kinase G

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/11/25 12:35:57」(JST)

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  • A PKG inhibitor increases Ca2+-regulated exocytosis in guinea pig antral mucous cells: cAMP accumulation via PDE2A inhibition.
  • Tanaka S, Tanaka R, Harada S, Kohda Y, Matsumura H, Shimamoto C, Sawabe Y, Marunaka Y, Kuwabara H, Takahashi Y, Ito S, Nakahari T.SourceDept. of Physiology, Osaka Medical College, Takatsuki 569-8686, Japan.
  • American journal of physiology. Gastrointestinal and liver physiology.Am J Physiol Gastrointest Liver Physiol.2013 May;304(9):G773-80. doi: 10.1152/ajpgi.00281.2012. Epub 2013 Feb 28.
  • In antral mucous cells, acetylcholine (ACh, 1 μM) activates Ca(2+)-regulated exocytosis, consisting of an initial peak that declines rapidly (initial transient phase) followed by a second slower decline (late phase) lasting during ACh stimulation. The addition of 8-bromo-cGMP (8-BrcGMP) enhanced th
  • PMID 23449671
  • Inhibition of diuretic stimulation of an insect secretory epithelium by a cGMP-dependent protein kinase.
  • Ruka KA, Miller AP, Blumenthal EM.SourceDept. of Biological Sciences, Marquette Univ., P.O. Box 1881, Milwaukee, WI 53201-1881.
  • American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2013 May;304(9):F1210-6. doi: 10.1152/ajprenal.00231.2012. Epub 2013 Feb 27.
  • The rate of urine secretion by insect Malpighian tubules (MTs) is regulated by multiple diuretic and antidiuretic hormones, often working either synergistically or antagonistically. In the Drosophila melanogaster MT, only diuretic factors have been reported. Two such agents are the biogenic amine ty
  • PMID 23445619


  • Cyclic GMP-Dependent Signaling in Cardiac Myocytes
  • Circulation journal : official journal of the Japanese Circulation Society 76(8), 1819-1825, 2012-07-25
  • … Cyclic GMP (cGMP) and its effector kinase PKG regulate diverse cellular functions. … In cardiac myocytes, cGMP is produced by soluble and particulate guanylyl cyclases (GCs), the former stimulated by nitric oxide and the latter by natriuretic peptides, and is hydrolyzed to inactive 5′-GMP by cGMP-phosphodiesterases (PDEs). … cGMP-PKG modulates cardiac contractility, hypertrophy and remodeling, and exerts cardioprotection. …
  • NAID 10030504080
  • Hydrogen Peroxide Enhances Vasodilatation by Increasing Dimerization of cGMP-Dependent Protein Kinase Type Iα
  • DOU Dou,ZHENG Xiaoxu,LIU Juan,XU Xiaojian,YE Liping,GAO Yuansheng
  • Circulation journal : official journal of the Japanese Circulation Society 76(7), 1792-1798, 2012-06-25
  • … Background: cGMP-dependent protein kinase type I (PKG I) plays a key role in vasodilatation caused by cGMP-elevating agents. … In isolated porcine coronary arteries, H2O2 increased the dimers of total PKG I in a concentration-dependent manner, but had no effect on dimerization of PKG Iβ. …
  • NAID 10030503931
  • Stabilization of cGMP-dependent protein kinase G (PKG) expression in vascular smooth muscle cells : contribution of 3'UTR of its mRNA
  • Sellak Hassan,Lincoln Thomas M.,Choi Chung-Sik
  • The journal of biochemistry 149(4), 433-441, 2011-04-01
  • NAID 10030584717


Genes and proteins [edit] PKG are serine/threonine kinases that are present in a variety of eukaryotes ranging from the unicellular organism Paramecium to humans. Two PKG genes, coding for PKG type I (PKG-I) and type II (PKG-II ...
プロテインキナーゼ cGMP-Dependent Protein Kinase 製品説明 cGMP-Dependent Protein Kinaseは、セリン/スレオニンをリン酸化するプロテインキナーゼで、平滑筋に存在し、その他の様々な組織にも微量ながら存在します。細胞内cGMP ...


cGMP - dependent protein kinasecGMP-Dependent Protein Kinases and cGMP Click on image to view larger version.Frontiers in Bioscience 12, 1814-1832  cGMP dependent protein kinase (PKGFigure 1. Sildenafil, PKG-1 and

リンク元サイクリックGMP依存性タンパク質リン酸化酵素」「cGMP依存性タンパク質リン酸化酵素」「G-kinase」「cyclic GMP-dependent protein kinase
関連記事dependent」「protein」「kinase」「kina」「protein kinase



cGMP-dependent protein kinaseprotein kinase GG-kinase



cGMP-dependent protein kinase




cGMP-dependent protein kinaseprotein kinase G

cyclic GMP-dependent protein kinase」


cGMP-dependent protein kinaseprotein kinase G



  • adj.
  • 依存性の、依存的な、依存型の、依存の

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「relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"」

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「『頼っている』,依存している,従属している / 扶養される人(家族)」

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「addicted to a drug」
dependant, drug-addicted, hooked, strung-out

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「contingent on something else」
dependant, qualified

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「(of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence"」


  [★] 蛋白質

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「any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"」

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  [★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase

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「an enzyme that catalyzes the conversion of a proenzyme to an active enzyme」



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「the basic unit of money in Papua New Guinea」

protein kinase」

  [★] プロテインキナーゼ

protein kinases