WordNet

remove the bones from; "bone the turkey before roasting it" (同)debone
the porous calcified substance from which bones are made (同)osseous_tissue
consisting of or made up of bone; "a bony substance"; "the bony framework of the body"
a shade of white the color of bleached bones (同)ivory, pearl, off-white
rigid connective tissue that makes up the skeleton of vertebrates (同)os
any of various squash plants grown for their elongated fruit with smooth dark green skin and whitish flesh (同)marrow squash, vegetable_marrow
the fatty network of connective tissue that fills the cavities of bones (同)bone_marrow
very tender and very nutritious tissue from marrowbones (同)bone_marrow
large elongated squash with creamy to deep green skins (同)vegetable_marrow
having bones as specified; "his lanky long-boned body"
having had the bones removed; "a boneless rib roast"; "a boned (or deboned) fish" (同)deboned
a percussion instrument consisting of a pair of hollow pieces of wood or bone (usually held between the thumb and fingers) that are made to click together (as by Spanish dancers) in rhythm with the dance (同)castanets, clappers, finger cymbals

PrepTutorEJDIC

〈C〉骨 / 〈U〉骨を作っている物質,骨質 / 《複数形で》骨格;死骸(がい) / 〈魚など〉‘の'骨を取る
髄(ずい),骨髄 / 精髄,粋 / 力,活力
(魚など)骨を取り除いた / (衣服が)(コルセットなどで)骨で張りをつけた[ような]
(体内にできる)新生物;腫瘍(しゅよう)

UpToDate Contents

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1. 骨髄穿刺塗抹標本の評価 evaluation of bone marrow aspirate smears
2. 芽球性形質細胞様樹状細胞腫瘍 blastic plasmacytoid dendritic cell neoplasm
3. 鎌状赤血球症における骨関節合併症 bone and joint complications in sickle cell disease
4. 小児および思春期における良性骨腫瘍：概要 benign bone tumors in children and adolescents an overview
5. 骨髄炎の疑いがある状況での画像検査法 approach to imaging modalities in the setting of suspected osteomyelitis

English Journal

Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc.

Stoddart A, Wang J, Fernald AA, Karrison T, Anastasi J, Le Beau MM.Author information Department of Medicine.AbstractTherapy-related myeloid neoplasms (t-MN) are a late complication of the successful use of cytotoxic therapy for patients with cancer. A heterozygous deletions of the long arm of chromosome 5 [del(5q)], observed in 40% of patients, is associated with prior exposure to alkylating agents, and a high frequency of TP53 loss or mutation. In previous studies, we demonstrated that haploinsufficiency of 2 del(5q) genes, Egr1, and Apc, individually play a role in the pathogenesis of hematologic disease in mice. We now show that loss of one copy of Egr1 or Tp53 in an Apc haploinsufficient background (Apc (del/+)) accelerated the development of a macrocytic anemia with monocytosis, early features of t-MN. The development of anemia was significantly accelerated by treatment of mice with the alkylating agent, N-ethyl-N-nitrosourea (ENU), regardless of the levels of expression of Egr1 and Tp53. Transplantation of either wild type; Egr1(+/-); Tp53(+/-); Apc(del/+); or Egr1(+/-), Apc(del/+) bone marrow cells into lethally irradiated Apc(del/+) recipients resulted in rapid development of anemia that was further accelerated by administration of ENU to recipients, demonstrating that the Apc(del/+)-induced anemia was cell extrinsic and potentiated by ENU mutagenesis. These data emphasize the synergistic role of cell intrinsic and cell extrinsic (microenvironment) factors in the pathogenesis of t-MN, and raise awareness of the deleterious effects of cytotoxic therapy on the stromal microenvironment.
Blood.Blood.2014 Jan 9;123(2):228-38. doi: 10.1182/blood-2013-05-506568. Epub 2013 Nov 21.
Therapy-related myeloid neoplasms (t-MN) are a late complication of the successful use of cytotoxic therapy for patients with cancer. A heterozygous deletions of the long arm of chromosome 5 [del(5q)], observed in 40% of patients, is associated with prior exposure to alkylating agents, and a high fr
PMID 24264229

Epstein-Barr virus-driven bone marrow aplasia and plasmacytosis mimicking a plasma cell neoplasm.

Desborough MJ, Grech H.
British journal of haematology.Br J Haematol.2014 Jan 9. doi: 10.1111/bjh.12721. [Epub ahead of print]
PMID 24405048

NF-kappa B mediated Up-regulation of CCCTC-binding factor in pediatric acute lymphoblastic leukemia.

Zhang H, Zhu L, He H, Zhu S, Zhang W, Liu X, Zhao X, Gao C, Mei M, Bao S, Zheng H.AbstractBACKGROUND: Acute lymphoblastic leukemia (ALL) is the most frequently occurring malignant neoplasm in children. Despite advances in treatment and outcomes for ALL patients, the pathogenesis of the disease remains unclear. Microarray analysis of samples from 100 Chinese children with ALL revealed the up-regulation of CTCF (CCCTC binding factor). CTCF is a highly conserved 11-zinc finger protein that is involved in many human cancers; however, the biological function of CTCF in pediatric ALL is unknown.
Molecular cancer.Mol Cancer.2014 Jan 7;13(1):5. [Epub ahead of print]
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most frequently occurring malignant neoplasm in children. Despite advances in treatment and outcomes for ALL patients, the pathogenesis of the disease remains unclear. Microarray analysis of samples from 100 Chinese children with ALL revealed the
PMID 24393203