betaine-homocysteine S-methyltransferase

出典: meddic


betaine-homocysteine methyltransferase

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/12/19 15:52:47」(JST)

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  • Splicing variants of the porcine betaine-homocysteine S-methyltransferase gene: implications for mammalian metabolism.
  • Ganu R, Garrow T, Koutmos M, Rund L, Schook LB.SourceDivision of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA.
  • Gene.Gene.2013 Oct 25;529(2):228-37. doi: 10.1016/j.gene.2013.07.103. Epub 2013 Aug 13.
  • Betaine-homocysteine S-methyltransferase (BHMT) activity is only detected in the liver of rodents, but in both the liver and kidney cortex of humans and pigs; therefore, the pig was chosen as a model to define the spatial and temporal expression of BHMT during development. During fetal development,
  • PMID 23948084
  • Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G polymorphisms influence on leukocyte genomic DNA methylation level.
  • Weiner AS, Boyarskikh UA, Voronina EN, Mishukova OV, Filipenko ML.SourceInstitute of Chemical Biology and Fundamental Medicine, Lavrentjeva, 8, 630090 Novosibirsk, Russia; Novosibirsk State University, Pirogova Street, 2, 630090 Novosibirsk, Russia.
  • Gene.Gene.2013 Oct 5. pii: S0378-1119(13)01332-2. doi: 10.1016/j.gene.2013.09.098. [Epub ahead of print]
  • Methionine synthase (MTR) and methylenetetrahydrofolate reductase (MTHFR) enzymes are involved in the metabolism of methyl groups, and thus have an important role in the maintenance of proper DNA methylation level. In our study we aimed to evaluate the effect of the polymorphism A2756G (rs1805087) i
  • PMID 24103477
  • Effects of hyperhomocysteinemia and betaine-homocysteine S-methyltransferase inhibition on hepatocyte metabolites and the proteome.
  • Selicharová I, Kořínek M, Demianová Z, Chrudinová M, Mládková J, Jiráček J.SourceInstitute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Praha, Czech Republic.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2013 Aug;1834(8):1596-606. doi: 10.1016/j.bbapap.2013.05.009. Epub 2013 May 18.
  • Both cardiovascular disease and liver injury are major public health issues. Hyperhomocysteinemia has been linked to cardiovascular diseases, and defects in methyl group metabolism, often resulting in hyperhomocysteinemia, are among the key molecular events postulated to play a role in liver injury.
  • PMID 23689031


  • L-serine attenuate steatosis by suppression of hyperhomocysteinemia
  • Hepatic Cystathionine β-Synthase Activity Does Not Increase in Response to Methionine Supplementation in Rats Fed a Low Casein Diet : Association with Plasma Homocysteine Concentrations
  • Journal of nutritional science and vitaminology 55(2), 178-185, 2009-04-01
  • NAID 10025970986
  • High Casein Diet Decreases Plasma Homocysteine Concentration in Rats
  • Journal of nutritional science and vitaminology 55(1), 22-30, 2009-02
  • NAID 110007110612







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