WordNet
- any of various antibiotics obtained from Penicillium molds (or produced synthetically) and used in the treatment of various infections and diseases
PrepTutorEJDIC
- ペニシリン(坑生物質の一種)
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/01 06:08:10」(JST)
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Benzathine benzylpenicillin
|
Combination of |
Benzylpenicillin |
Antibiotic |
Benzathine |
Stabilizer |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Identifiers |
CAS Registry Number |
1538-09-6 N |
ATC code |
J01CE08 |
PubChem |
CID: 15232 |
ChemSpider |
14498 N |
UNII |
SSZ1S4I0US N |
ChEBI |
CHEBI:51352 N |
ChEMBL |
CHEMBL1200651 N |
N (what is this?) (verify) |
Benzathine benzylpenicillin (rINN) is a form of penicillin also known as benzathine penicillin. It is an antibiotic useful for the treatment of a number of bacterial infections.
It is slowly absorbed into the circulation, after intramuscular injection, and hydrolysed to benzylpenicillin in vivo. It is the drug-of-choice when prolonged low concentrations of benzylpenicillin are required and appropriate, allowing prolonged antibiotic action over 2–4 weeks after a single IM dose. It is marketed by Wyeth under the trade name Bicillin L-A.
Medical uses for benzathine penicillin include: prevention of rheumatic fever and early or latent syphilis.[1]
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[2]
Adverse effects
Further information: Penicillin drug reaction
Compendial status
- British Pharmacopoeia [3]
References
- ^ Rossi S, editor, ed. (2006). Australian Medicines Handbook. Adelaide: Australian Medicines Handbook. ISBN 0-9757919-2-3.
- ^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
- ^ British Pharmacopoeia Commission Secretariat. "Index (BP 2009)" (PDF). Retrieved 26 March 2010.
Antibacterials: cell envelope antibiotics (J01C-J01D)
|
|
Intracellular |
- inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
|
|
Glycopeptide |
- inhibit PG chain elongation: Vancomycin# (Oritavancin
- Telavancin)
- Teicoplanin (Dalbavancin)
- Ramoplanin
|
|
β-lactams/
(inhibit PBP
cross-links) |
|
|
Other |
- polymyxins/detergent
- depolarizing
- hydrolyze NAM-NAG
- Gramicidin
- Isoniazid
- Teixobactin
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
Index of bacterial disease
|
|
Description |
|
|
Disease |
- Gram-positive firmicutes
- Gram-positive actinobacteria
- Gram-negative proteobacteria
- Gram-negative non-proteobacteria
- Cholera
- Tuberculosis
|
|
Treatment |
- Antibiotics
- cell wall
- nucleic acid
- mycobacteria
- protein synthesis
- other
- Antibodies
|
|
|
UpToDate Contents
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English Journal
- A Population Pharmacokinetic Modeling Approach Shows that Serum Penicillin G Concentrations Are Below Inhibitory Concentrations by Two Weeks after Benzathine Penicillin G Injection in the Majority of Young Adults.
- Neely M1, Kaplan EL2, Blumer JL3, Faix DJ4, Broderick MP4.
- Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2014 Nov;58(11):6735-41. doi: 10.1128/AAC.02744-14. Epub 2014 Sep 2.
- Serum penicillin G falls to low levels 2 weeks after injection as benzathine penicillin G (BPG) in young adults. Using Pmetrics and previously reported penicillin G pharmacokinetic data after 1.2 million units were given as BPG to 329 male military recruits, here we develop the first reported popula
- PMID 25182635
- Primary syphilis of the oropharynx: unusual location of a chancre.
- Drago F1, Ciccarese G2, Cogorno L1, Tomasini CF3, Cozzani EC1, Riva SF1, Parodi A1.
- International journal of STD & AIDS.Int J STD AIDS.2014 Sep 4. pii: 0956462414551235. [Epub ahead of print]
- A 33-year-old man presented with a two-week history of an asymptomatic ulcer of the oropharynx and submandibular lymph nodes swelling. Laboratory examinations resulted normal, but serological tests revealed positivity for rapid plasma reagin, Treponema pallidum haemagglutination assay and anti-T. pa
- PMID 25193247
Japanese Journal
- Investigation of DNA damage in lymphocytes exposed to benzathine penicillin G
- KOSEOGLU VEDAT,KISMET EROL,SOYSAL YASEMIN,ULUCAN HAKAN,DUNDAROZ RUSEN,IMIRZAHOGLU NECAT,GOKCAY ERDAL
- Pediatrics international : official journal of the Japan Pediatric Society 46(4), 415-418, 2004-08-01
- NAID 10018369034
- Evaluation of DNA damage using the comet assay in children on long-term benzathine penicillin for secondary prophylaxis of rheumatic fever
- DUNDAROZ RUSEN,ULUCAN HAKAN,DENLI METIN,KARAPINAR KASIM,AYDIN HALIL IBRAHIM,BALTACI VOLKAN
- Pediatrics international : official journal of the Japan Pediatric Society 43(3), 276-280, 2001-06-01
- NAID 10010092369
Related Links
- Find patient medical information for Penicillin G Benzathine Intramuscular on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. ... Precautions Before using this medication ...
- Penicillin G benzathine injection comes as a suspension (liquid) in a prefilled syringe to inject into the muscles of the buttocks or thigh by a doctor or nurse in a medical facility. Penicillin G benzathine injection may be ...
Related Pictures
★リンクテーブル★
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ベンザチンペニシリンG
- 関
- benzathine benzylpenicillin
- 同
- Bicillin