WordNet

staining readily with basic dyes
a leukocyte with basophilic granules easily stained by basic stains (同)basophile

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/12 19:42:01」(JST)

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Basophilic stippling aka Punctate basophilia refers to an observation found when observing a blood smear in which erythrocytes display small dots at the periphery. These dots are the visualization of ribosomes and can often be found in the peripheral blood smear, even in some normal individuals.^[1]

It is associated with several conditions, including:

Myelodysplastic Syndrome

Sideroblastic anemia^[2]

Lead poisoning (normocytic anemia)^[3]

Arsenic poisoning

Beta thalassemia (though some have questioned this)^[4]

Alpha-thalassemia, HbH Disease

Hereditary Pyrimidine 5'-Nucleotidase Deficiency
Thrombotic thrombocytopenic purpura

References

^ Cheson, B. D.; Rom, W. N.; Webber, R. C. (1984). "Basophilic stippling of red blood cells: A nonspecific finding of multiple etiology". American journal of industrial medicine 5 (4): 327–34. PMID 6202140.
^ "Pathology". Retrieved 2009-02-08.
^ Valentine WN, Paglia DE, Fink K, Madokoro G (October 1976). "Lead poisoning: association with hemolytic anemia, basophilic stippling, erythrocyte pyrimidine 5'-nucleotidase deficiency, and intraerythrocytic accumulation of pyrimidines". J. Clin. Invest. 58 (4): 926–32. doi:10.1172/JCI108545. PMC 333255. PMID 965496.
^ Harrington AM, Ward PC, Kroft SH (March 2008). "Iron deficiency anemia, beta-thalassemia minor, and anemia of chronic disease: a morphologic reappraisal". Am. J. Clin. Pathol. 129 (3): 466–71. doi:10.1309/LY7YLUPE7551JYBG. PMID 18285271.

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1. 末梢血塗抹標本の評価 evaluation of the peripheral blood smear
2. 小児期の鉛中毒：臨床症状および診断 childhood lead poisoning clinical manifestations and diagnosis
3. 成人に生じる業務上の鉛中毒 adult occupational lead poisoning
4. 赤血球産生調節 regulation of erythropoiesis
5. 重症疾患に関連する神経筋脱力 neuromuscular weakness related to critical illness

English Journal

Lead Poisoning and Anemia Associated with Use of Ayurvedic Medications Purchased on the Internet--Wisconsin, 2015.

Meiman J, Thiboldeaux R, Anderson H.
MMWR. Morbidity and mortality weekly report.MMWR Morb Mortal Wkly Rep.2015 Aug 21;64(32):883.
On April 30, 2015, the Wisconsin Division of Public Health (WDPH) was notified by a local health department of an elevated blood lead level (BLL) in a female patient aged 64 years. All Wisconsin laboratories are required to provide BLL testing results performed on any state resident to WDPH, and WDP
PMID 26292208

Prominent basophilic stippling and hemochromatosis in glucose-6-phosphate dehydrogenase deficiency.

Vander Meeren S1, Van Damme A, Jochmans K.
International journal of hematology.Int J Hematol.2015 Feb;101(2):112-3. doi: 10.1007/s12185-014-1716-6. Epub 2014 Dec 9.
PMID 25487752

Pyrimidine-5'-nucleotidase Campinas, a new mutation (p.R56G) in the NT5C3 gene associated with pyrimidine-5'-nucleotidase type I deficiency and influence of Gilbert's Syndrome on clinical expression.

Santos Ad1, Dantas LE1, Traina F1, Albuquerque DM1, Chaim EA1, Saad ST2.
Blood cells, molecules & diseases.Blood Cells Mol Dis.2014 Dec;53(4):246-52. doi: 10.1016/j.bcmd.2014.05.009. Epub 2014 Aug 18.
Pyrimidine-5'-nucleotidase type I (P5'NI) deficiency is an autosomal recessive condition that causes nonspherocytic hemolytic anemia, characterized by marked basophilic stippling and pyrimidine nucleotide accumulation in erythrocytes. We herein present two African descendant patients, father and dau
PMID 25153905

Japanese Journal

Age-Related Hematological Changes in Normal F344 Rats: during the Neonatal Period

Kojima Sayuri,Haruta Junko,Enomoto Akiko [他],FUJISAWA Hideki,HARADA Takanori,MAITA Keizo
Experimental animals 48(3), 153-159, 1999-07-00
… Microscopic examination of blood smears revealed that erythrocytes at birth had characteristic morphological features such as anisocytosis, polychromasia, basophilic stippling, Howell-Jolly body, and erythroblastosis. …
NAID 10007347917

インスリン非依存型糖尿病に発症した漢方薬(珍〓降糖)による鉛中毒

山田祐也,迫田寛人,井上徹,久保正治,伏見尚子,南武志,亀山正邦
糖尿病 41(10), 933-936, 1998-10-30
NAID 10005567681

Lead poisoning. Association with hemolytic anemia, basophilic stippling, erythrocyte pyrimidine 5'-nucleotidase deficiency, and intraerythrocytic accumulation of pyrimidines