aromatase inhibitors

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/05/19 00:12:37」(JST)

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  • Adjuvant treatments of breast cancer increase the risk of depressive disorders: A population-based study.
  • Chang CH1, Chen SJ2, Liu CY3.
  • Journal of affective disorders.J Affect Disord.2015 Aug 15;182:44-9. doi: 10.1016/j.jad.2015.04.027. Epub 2015 Apr 23.
  • BACKGROUND: Previous studies have posited conflicting results regarding depressive disorders among breast cancer survivors who received adjuvant therapies including chemotherapy, radiotherapy, selective estrogen receptor modulator (e.g. tamoxifen), third-generation aromatase inhibitors (AIs; e.g. an
  • PMID 25973782
  • Synthesis and molecular docking of 1,2,3-triazole-based sulfonamides as aromatase inhibitors.
  • Pingaew R1, Prachayasittikul V2, Mandi P3, Nantasenamat C3, Prachayasittikul S4, Ruchirawat S5, Prachayasittikul V6.
  • Bioorganic & medicinal chemistry.Bioorg Med Chem.2015 Jul 1;23(13):3472-80. doi: 10.1016/j.bmc.2015.04.036. Epub 2015 Apr 17.
  • A series of 1,4-disubstituted-1,2,3-triazoles (13-35) containing sulfonamide moiety were synthesized and evaluated for their aromatase inhibitory effects. Most triazoles with open-chain sulfonamide showed significant aromatase inhibitory activity (IC50=1.3-9.4μM). Interestingly, the meta analog of
  • PMID 25934226
  • Pattern of hormone receptors and human epidermal growth factor receptor 2 status in sub-Saharan breast cancer cases: Private practice experience.
  • Nwafor CC1, Keshinro SO.
  • Nigerian journal of clinical practice.Niger J Clin Pract.2015 Jul-Aug;18(4):553-8. doi: 10.4103/1119-3077.156905.
  • INTRODUCTION: Breast cancer is the most common cancer among women globally. With immunohistochemistry (IHC), breast cancer is classified into four groups based on IHC profile of estrogen receptor (ER)/progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2/neu) expression, posi
  • PMID 25966732


  • p53 accumulation is a strong predictor of recurrence in estrogen receptor-positive breast cancer patients treated with aromatase inhibitors
  • Yamamoto Mitsugu,Hosoda Mitsuchika,Nakano Kiichiroh,Jia Shusheng,Hatanaka Kanako C.,Takakuwa Emi,Hatanaka Yutaka,Matsuno Yoshihiro,Yamashita Hiroko
  • Cancer science 105(1), 81-88, 2014-01
  • Aromatase inhibitors have played a central role in endocrine therapy for estrogen receptor (ER)-positive breast cancer in postmenopausal women. … However, factors predictive of the efficacy of aromatase inhibitors, and prognostic factors, both for early and late recurrence in women treated with adjuvant aromatase inhibitors have not been identified. …
  • NAID 120005411143
  • Third-generation Aromatase Inhibitor Improved Adult Height in a Japanese Boy with Testotoxicosis
  • , , , , ,
  • Clinical Pediatric Endocrinology 23(2), 53-58, 2014
  • … A572V] in the LH/CGR gene, who was the first boy treated with a third-generation aromatase inhibitor (AI) and reached his adult height in Japan. …
  • NAID 130004853602
  • レトロゾールによる内分泌療法が有効であった91歳男性乳癌の1例
  • 中田 琢巳,森川 あけみ,杉山 保幸,山田 鉄也
  • 日本臨床外科学会雑誌 75(4), 906-910, 2014
  • 症例は91歳,男性.併存症として,閉塞性動脈硬化症・狭心症・2型糖尿病・高血圧症などがあり,当院内科での治療中に左乳頭下に3.5cmの腫瘤を自覚するようになり当科を受診した.男性乳癌と診断されたが初期治療としては合併症を考慮してレトロゾール内服による内分泌療法が選択された.投与開始後から腫瘍の縮小が認められ,約6カ月間で腫瘤は1.7cmまでの縮小を認め,自覚症状は著明に改善した.症例の少なさから女 …
  • NAID 130004713878


Aromatase inhibitors stop the production of estrogen in postmenopausal women. Aromatase inhibitors work by blocking the enzyme aromatase, which turns the hormone androgen into small amounts of estrogen in the body. This ...
Aromatase inhibitors (drugs that lower estrogen levels) may someday prove to be as good as or even better than tamoxifen or raloxifene in reducing breast cancer risk, but they haven’t been well studied for this use. More ...


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aromatase inhibitor



  • n.

WordNet   license wordnet

「a substance that retards or stops an activity」

PrepTutorEJDIC   license prepejdic

「抑制する人(物) / 化学反応抑制剤」