アクア・リン4
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- AQP4
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/20 17:30:41」(JST)
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| Aquaporin 4 |
Double layered 2D crystal structure of aquaporin-4 (AQP4M23) at 3.2 a resolution by electron crystallography. |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
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3GD8
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| Identifiers |
| Symbols |
AQP4 ; HMIWC2; MIWC |
| External IDs |
OMIM: 600308 MGI: 107387 HomoloGene: 37507 IUPHAR: AQP4 ChEMBL: 5964 GeneCards: AQP4 Gene |
| Gene ontology |
| Molecular function |
• water transmembrane transporter activity
• water channel activity
• porin activity
|
| Cellular component |
• cytoplasm
• plasma membrane
• integral to plasma membrane
• cell-cell junction
• external side of plasma membrane
• basolateral plasma membrane
• T-tubule
• protein complex
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| Biological process |
• transport
• water transport
• nervous system development
• female pregnancy
• excretion
• sensory perception of sound
• response to radiation
• carbon dioxide transport
• hyperosmotic salinity response
• multicellular organismal water homeostasis
• protein homooligomerization
• response to glucocorticoid stimulus
• transmembrane transport
• renal water absorption
• cellular response to interferon-gamma
• cellular response to estradiol stimulus
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| Sources: Amigo / QuickGO |
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| Orthologs |
| Species |
Human |
Mouse |
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| Entrez |
361 |
11829 |
|
| Ensembl |
ENSG00000171885 |
ENSMUSG00000024411 |
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| UniProt |
P55087 |
P55088 |
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| RefSeq (mRNA) |
NM_001650 |
NM_009700 |
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| RefSeq (protein) |
NP_001641 |
NP_033830 |
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| Location (UCSC) |
Chr 18:
24.43 – 24.45 Mb |
Chr 18:
15.39 – 15.4 Mb |
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| PubMed search |
[1] |
[2] |
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Aquaporin 4 also known as AQP4 is a protein which in humans is encoded by the AQP4 gene.[1] AQP4 belongs to the aquaporin family of integral membrane proteins that conduct water through the cell membrane.
Contents
- 1 Function
- 2 Pathology
- 3 See also
- 4 References
- 5 Further reading
- 6 External links
Function
AQP4 is constitutively expressed in the basolateral cell membrane of principal collecting duct cells in the kidney and provide a pathway for water to exit these cells.[2]
AQP4 is also expressed in astrocytes and is upregulated by direct insult to the central nervous system.[3]
Pathology
Aquaporin-4 has been proposed as the primary autoimmune target in neuromyelitis optica.[4][5]
See also
References
- ^ Jung JS, Bhat RV, Preston GM, Guggino WB, Baraban JM, Agre P (December 1994). "Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance". Proceedings of the National Academy of Sciences of the United States of America 91 (26): 13052–6. doi:10.1073/pnas.91.26.13052. PMC 45579. PMID 7528931.
- ^ Agre P, Nielsen S (1996). "The aquaporin family of water channels in kidney". Nephrologie 17 (7): 409–15. PMID 8987045.
- ^ Nagelhus EA, Mathiisen TM, Ottersen OP (2004). "Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1". Neuroscience 129 (4): 905–13. doi:10.1016/j.neuroscience.2004.08.053. PMID 15561407.
- ^ Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR (August 2005). "IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel". J. Exp. Med. 202 (4): 473–7. doi:10.1084/jem.20050304. PMC 2212860. PMID 16087714.
- ^ Bradl M, Lassmann DH (September 2008). "Anti-aquaporin-4 antibodies in neuromyelitis optica: how to prove their pathogenetic relevance?". International MS Journal / MS Forum 15 (3): 75–8. PMID 18812056.
Further reading
- Strand L, Moe SE, Solbu TT et al. (2009). "Roles of aquaporin-4 isoforms and amino acids in square array assembly". Biochemistry 48 (25): 5785–93. doi:10.1021/bi802231q. PMID 19445480.
- Goodyear MJ, Crewther SG, Junghans BM (2009). "A role for aquaporin-4 in fluid regulation in the inner retina". Vis. Neurosci. 26 (2): 159–65. doi:10.1017/S0952523809090038. PMID 19366470.
- Matsushita T, Matsuoka T, Isobe N et al. (2009). "Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders". Tissue Antigens 73 (2): 171–6. doi:10.1111/j.1399-0039.2008.01172.x. PMID 19140826.
- Rubino E, Rainero I, Vaula G et al. (2009). "Investigating the genetic role of aquaporin4 gene in migraine". The journal of headache and pain 10 (2): 111–4. doi:10.1007/s10194-009-0100-z. PMID 19209385.
- Benarroch EE (2007). "Aquaporin-4, homeostasis, and neurologic disease". Neurology 69 (24): 2266–8. doi:10.1212/01.wnl.0000286385.59836.e2. PMID 18071147.
- Ho JD, Yeh R, Sandstrom A et al. (2009). "Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance". Proc. Natl. Acad. Sci. U.S.A. 106 (18): 7437–42. doi:10.1073/pnas.0902725106. PMC 2678640. PMID 19383790.
- Assereto S, Mastrototaro M, Stringara S et al. (2008). "Aquaporin-4 expression is severely reduced in human sarcoglycanopathies and dysferlinopathies". Cell Cycle 7 (14): 2199–207. doi:10.4161/cc.7.14.6272. PMID 18641458.
- Dibas A, Yang MH, He S et al. (2008). "Changes in ocular aquaporin-4 (AQP4) expression following retinal injury". Mol. Vis. 14: 1770–83. PMC 2559817. PMID 18836575.
- Sorani MD, Zador Z, Hurowitz E et al. (2008). "Novel variants in human Aquaporin-4 reduce cellular water permeability". Hum. Mol. Genet. 17 (15): 2379–89. doi:10.1093/hmg/ddn138. PMC 2733814. PMID 18511455.
- Ng WH, Hy JW, Tan WL et al. (2009). "Aquaporin-4 expression is increased in edematous meningiomas". Journal of Clinical Neuroscience 16 (3): 441–3. doi:10.1016/j.jocn.2008.04.028. PMID 19153045.
- Nishiyama S, Ito T, Misu T et al. (2009). "A case of NMO seropositive for aquaporin-4 antibody more than 10 years before onset". Neurology 72 (22): 1960–1. doi:10.1212/WNL.0b013e3181a82621. PMID 19487655.
- Misu T, Fujihara K, Itoyama Y (May 2008). "Neuromyelitis optica and anti-aquaporin 4 antibody – an overview". Brain Nerve (in Japanese) 60 (5): 527–37. PMID 18516975.
- Dibas AI, Mia AJ, Yorio T (1998). "Aquaporins (water channels): role in vasopressin-activated water transport". Proc. Soc. Exp. Biol. Med. 219 (3): 183–99. doi:10.3181/00379727-219-44332. PMID 9824541.
- Doi H, Matsushita T, Isobe N et al. (2009). "Hypercomplementemia at relapse in patients with anti-aquaporin-4 antibody". Mult. Scler. 15 (3): 304–10. doi:10.1177/1352458508099139. PMID 19028829.
- Pittock SJ, Lennon VA (2008). "Aquaporin-4 autoantibodies in a paraneoplastic context". Arch. Neurol. 65 (5): 629–32. doi:10.1001/archneur.65.5.629. PMID 18474738.
- Matsushita T, Isobe N, Matsuoka T et al. (2009). "Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese". Mult. Scler. 15 (7): 834–47. doi:10.1177/1352458509104595. PMID 19465451.
- Graber DJ, Levy M, Kerr D, Wade WF (2008). "Neuromyelitis optica pathogenesis and aquaporin 4". Journal of neuroinflammation 5: 22. doi:10.1186/1742-2094-5-22. PMC 2427020. PMID 18510734.
- Baba T, Nakashima I, Kanbayashi T et al. (2009). "Narcolepsy as an initial manifestation of neuromyelitis optica with anti-aquaporin-4 antibody". J. Neurol. 256 (2): 287–8. doi:10.1007/s00415-009-0139-4. PMID 19266146.
- Xu H, Zhang Y, Wei W et al. (2009). "Differential expression of aquaporin-4 in human gastric normal and cancer tissues". Gastroenterol. Clin. Biol. 33 (1 Pt 1): 72–6. doi:10.1016/j.gcb.2008.07.010. PMID 19112001.
- Kadohira I, Abe Y, Nuriya M et al. (2008). "Phosphorylation in the C-terminal domain of Aquaporin-4 is required for Golgi transition in primary cultured astrocytes". Biochem. Biophys. Res. Commun. 377 (2): 463–8. doi:10.1016/j.bbrc.2008.09.155. PMID 18854171.
External links
- Aquaporin 4 at the US National Library of Medicine Medical Subject Headings (MeSH)
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Membrane transport protein: ion channels (TC 1A)
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Ca2+: Calcium channel
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| Ligand-gated |
- Inositol trisphosphate receptor
- Ryanodine receptor
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| Voltage-gated |
- L-type/Cavα
- N-type/Cavα2.2
- P-type/Cavα
- Q-type/Cavα2.1
- R-type/Cavα2.3
- T-type/Cavα
- α2δ-subunits
- β-subunits
- γ-subunits
- Cation channels of sperm
- Two-pore channel
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Na+: Sodium channel
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| Constitutively active |
- Epithelial sodium channel
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| Proton-gated |
- Amiloride-sensitive cation channel
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| Voltage-gated |
- Navα
- 1.1
- 1.2
- 1.3
- 1.4
- 1.5
- 1.6
- 1.7
- 1.8
- 1.9
- 7A
- Navβ
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K+: Potassium channel
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| Calcium-activated |
- BK channel
- SK channel
- IK channel
- KCa
- 1.1
- 2.1
- 2.2
- 2.3
- 3.1
- 4.1
- 4.2
- 5.1
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| Inward-rectifier |
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| Tandem pore domain |
- K2P
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 9
- 10
- 12
- 13
- 15
- 16
- 17
- 18
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| Voltage-gated |
- Kvα1-6
- 1.1
- 1.2
- 1.3
- 1.4
- 1.5
- 1.6
- 1.7
- 1.8
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-
-
-
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- Kvβ
- KCNIP
- minK/ISK
- minK/ISK-like
- MiRP
- Shaker gene
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Miscellaneous
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| Cl-: Chloride channel |
- Calcium-activated chloride channels
- Anoctamin
- Bestrophin
- Chloride Channel Accessory
- CFTR
- CLCN
- CLIC
- CLNS
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| H+: Proton channel |
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| M+: CNG cation channel |
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| M+: TRP cation channel |
- TRPA (1)
- TRPC
- TRPM
- TRPML
- TRPN
- TRPP
- TRPV
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| H2O (+ solutes): Porin |
- Aquaporin
- Voltage-dependent anion channel
- General bacterial porin family
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| Cytoplasm: Gap junction |
- Connexin: A
- GJA1
- GJA3
- GJA4
- GJA5
- GJA8
- GJA9
- GJA10
- B
- GJB1
- GJB2
- GJB3
- GJB4
- GJB5
- GJB6
- GJB7
- C
- D
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By gating mechanism
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| Ion channel class |
- Ligand-gated
- Light-gated
- Voltage-gated
- Stretch-activated
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see also disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), other
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UpToDate Contents
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English Journal
- Calcitonin gene-related peptide prevents blood-brain barrier injury and brain edema induced by focal cerebral ischemia reperfusion.
- Liu Z, Liu Q, Cai H, Xu C, Liu G, Li Z.SourceDepartment of Anatomy, Shandong University School of Medicine, Jinan 250012, China.
- Regulatory peptides.Regul Pept.2011 Nov 10;171(1-3):19-25. Epub 2011 Jun 28.
- Cerebral ischemia is one of the diseases that most compromise the human species. Therapeutic recovery of blood-brain barrier (BBB) disruption represents a novel promising approach to reduce brain injury after stroke. To determine the effects of calcitonin gene-related peptide (CGRP) on the BBB parti
- PMID 21718723
- Seropositive antiaquaporin-4 antibody associated with multisegmental myelitis in a patient with paracoccidioidomycosis.
- Brum DG, Donadi EA, Dos Santos AC, Takayanagui OM, Marques W Jr, Barreira AA.SourceDepartment of Neurosciences, Medical School of Ribeirao Preto, University of Sao Paulo, Brazil.
- Journal of the neurological sciences.J Neurol Sci.2011 Oct 15;309(1-2):151-3. Epub 2011 Jul 30.
- Since the description of the association between neuromyelitis optica (Devic's disease) and aquaporin 4 IgG antibody (NMO-IgG), the search for this antibody has been considered a highly recommended laboratory test when centromedullary multisegmental lesions are observed by magnetic resonance imaging
- PMID 21803375
Japanese Journal
- Autonomic Nerve-Regulated AQP5 Distribution in Salivary Glands and AQP5 Release into Saliva
- WANG Di,ISHIKAWA Yasuko
- Journal of oral biosciences 53(1), 38-47, 2011-02-20
- NAID 10027793648
- Vacuolar Proton Pumps and Aquaporins Involved in Rapid Internode Elongation of Deepwater Rice
- MUTO Yukari,SEGAMI Shoji,HAYASHI Hidehiro,SAKURAI Junko,MURAI HATANO Mari,HATTORI Yoko,ASHIKARI Motoyuki,MAESHIMA Masayoshi
- Bioscience, biotechnology, and biochemistry 75(1), 114-122, 2011-01-23
- … The increase in aquaporin expression might support quick elongation of internodes. …
- NAID 10027896894
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