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1. Neuromyelitis optica spectrum disorders
2. 成人における多発性硬化症の診断 diagnosis of multiple sclerosis in adults
3. Manifestations of hyponatremia and hypernatremia in adults
4. 脊髄および後根神経節に影響を与える腫瘍随伴性症候群 paraneoplastic syndromes affecting the spinal cord and dorsal root ganglia
5. 遺伝性痙性対麻痺 hereditary spastic paraplegia

English Journal

Detection of aquaporin-4 antibody using aquaporin-4 extracellular loop-based carbon nanotube biosensor for the diagnosis of neuromyelitis optica.

Son M1, Kim D2, Park KS3, Hong S4, Park TH5.
Biosensors & bioelectronics.Biosens Bioelectron.2016 Apr 15;78:87-91. doi: 10.1016/j.bios.2015.11.029. Epub 2015 Nov 12.
Here we propose a carbon nanotube (CNT) field-effect transistor (FET) functionalized with aquaporin-4 (AQP4) extracellular loop peptides for the rapid detection of AQP4 antibody without pretreatment. Neuromyelitis optica (NMO) is a rare disease of the central nerve system that affects the optic nerv
PMID 26594890

Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis.

Metz I1, Beißbarth T1, Ellenberger D1, Pache F1, Stork L1, Ringelstein M1, Aktas O1, Jarius S1, Wildemann B1, Dihazi H1, Friede T1, Brück W1, Ruprecht K1, Paul F1.
Neurology® neuroimmunology & neuroinflammation.Neurol Neuroimmunol Neuroinflamm.2016 Feb 2;3(2):e204. doi: 10.1212/NXI.0000000000000204. eCollection 2016.
OBJECTIVE: To assess in an observational study whether serum peptide antibody reactivities may distinguish aquaporin-4 (AQP4) antibody (Ab)-positive and -negative neuromyelitis optica spectrum disorders (NMOSD) and relapsing-remitting multiple sclerosis (RRMS).METHODS: We screened 8,700 peptides tha
PMID 26894206

Optic neuritis with positive HLA-B27: Characteristic phenotype in the Chinese population.

Zhao S1, Zhou H2, Peng X3, Zhu J4, Wang W5, Kang H2, Chen T2, Xu Q6, Wei S7.
Journal of the neurological sciences.J Neurol Sci.2016 Mar 15;362:100-5. doi: 10.1016/j.jns.2016.01.027. Epub 2016 Jan 18.
PURPOSE: This study retrospectively reviewed the clinical features of optic neuritis (ON) with positive HLA-B27.METHOD: Clinical data were reviewed for HLA-B27-positive ON in the Chinese People's Liberation Army General Hospital from January 2009 through June 2015. The prevalence of HLA-B27 and spon
PMID 26944126

Japanese Journal

疾患からみた細胞表面機能分子(第4回)視神経脊髄炎におけるAQP4

千原典夫
分子リウマチ治療 8(2), 96-99, 2015-05
NAID 40020464986

Antibodies to myelin oligodendrocyte glycoprotein in idiopathic optic neuritis

Nakajima Hideki,Motomura Masakatsu,Tanaka Keiko,Fujikawa Azusa,Nakata Ruka,Maeda Yasuhiro,Shima Tomoaki,Mukaino Akihiro,Yoshimura Shunsuke,Miyazaki Teiichiro,Shiraishi Hirokazu,Kawakami Atsushi,Tsujino Akira
BMJ Open 5(4), e007766, 2015-04-02
… Sera from patients were tested for antibodies to MOG and aquaporin-4 (AQP4) with a cell-based assay. … Results: 27.6% (8/29) were positive for MOG antibodies and 3.4% (1/29) were positive for AQP4. …
NAID 120005603868

NMOとMSの鑑別最前線

森雅裕
神経眼科 32(2), 120-127, 2015
… したと思われる疫学，症候，検査，治療効果の差異があることも明らかになっており鑑別に有用である．鑑別における最も有用な検査は抗AQP4抗体測定と頭部・脊髄MRI検査であり，全て行うことが望まれる．また，アストロサイト障害を反映する髄液GFAP，抗AQP4抗体産生に関与すると考えられている髄液IL-6の上昇はNMO診断を支持する所見となるので，視神経炎再発であっても鑑別が難しい場合には髄 …
NAID 130005087832

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