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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/01 06:24:05」(JST)

Aprindine is a Class 1b antiarrhythmic agent.^[1]

In one study, it delayed atrial fibrillation more than digoxin did.^[2]

It has shown effectiveness when given orally.^[3]

References

^ Sato R, Hisatome I, Tanaka Y; et al. (September 1991). "Aprindine blocks the sodium current in guinea-pig ventricular myocytes". Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. doi:10.1007/bf00183008. PMID 1660104.
^ Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). "Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation". Circ. J. 66 (6): 553–6. doi:10.1253/circj.66.553. PMID 12074271. ^{[dead link]}
^ Reid PR, Greene HL, Varghese PJ (December 1977). "Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome". Br Heart J 39 (12): 1353–60. doi:10.1136/hrt.39.12.1353. PMC 483421. PMID 603737.

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Enantioselective plasma protein binding of propafenone: mechanism, drug interaction, and species difference.

Hong Y, Tang Y, Zeng S.SourceDepartment of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Chirality.Chirality.2009 Jul;21(7):692-8. doi: 10.1002/chir.20666.
The interaction of propafenone (PPF) enantiomers with human plasma, human serum albumin (HSA), alpha(1)-acid glycoprotein (AGP), as well as with plasma from rat, rabbit, and cow was investigated using indirect chiral high performance liquid chromatography (HPLC) and ultrafiltration techniques. The s
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Effects of antiarrhythmic drugs on the hyperpolarization-activated cyclic nucleotide-gated channel current.

Tamura A, Ogura T, Uemura H, Reien Y, Kishimoto T, Nagai T, Komuro I, Miyazaki M, Nakaya H.SourceDepartment of Pharmacology, Chiba University Graduate School of Medicine, Chiba, Japan.
Journal of pharmacological sciences.J Pharmacol Sci.2009 Jun;110(2):150-9. Epub 2009 Jun 5.
After the report of the Cardiac Arrhythmia Suppression Trial, a tabular framework of the Sicilian Gambit has been proposed to display actions of antiarrhythmic drugs on ion channels and receptors and to provide more rational pharmacotherapy of arrhythmias. However, because effects of antiarrhythmic
PMID 19498275

Relationship between serum aprindine concentration and neurologic side effects in Japanese.

Tsuchishita Y, Fukumoto K, Kusumoto M, Ueno K.SourceDepartment of Pharmacy, Maizuru Kyosai Hospital, Federation of National Public Services and Affiliated Mutual Associations, Japan.
Biological & pharmaceutical bulletin.Biol Pharm Bull.2009 Apr;32(4):637-9.
The aim of this study was to evaluate the relationship between the neurologic side effects associated with serum aprindine concentrations and the safety range of aprindine for the prevention of neurologic side effects in 142 Japanese inpatients. Serum aprindine concentrations were determined by high
PMID 19336897

Effects of Antiarrhythmic Drugs on the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Current

TAMURA Atsushi,OGURA Takehiko,UEMURA Hiroko,REIEN Yoshie,KISHIMOTO Takashi,NAGAI Toshio,KOMURO Issei,MIYAZAKI Masaru,NAKAYA Haruaki
Journal of pharmacological sciences 110(2), 150-159, 2009-06-20
… The inhibitory effects of quinidine, disopyramide, cibenzoline, lidocaine, mexiletine, aprindine, propafenone, flecainide, propranolol, and verapamil on the HCN4 channel current were weak in their therapeutic concentrations, with IC50 values of 78.3, 249, 46.8, 276, 309, 43.7, 14.3, 1700, 50.5, and 44.9 μM, respectively, suggesting that the inhibitory effects on If would be clinically small. …
NAID 10025737030

Relationship between Serum Aprindine Concentration and Neurologic Side Effects in Japanese(Pharmacology)

TSUCHISHITA Yoshimasa,FUKUMOTO Kyoko,KUSUMOTO Masaaki,UENO Kazuyuki
Biological & pharmaceutical bulletin 32(4), 637-639, 2009-04-01
… The aim of this study was to evaluate the relationship between the neurologic side effects associated with serum aprindine concentrations and the safety range of aprindine for the prevention of neurologic side effects in 142 Japanese inpatients. … Serum aprindine concentrations were determined by high-performance liquid chromatography. …
NAID 110007160658

リンク元	「アプリンジン」
拡張検索	「aprindine hydrochloride」

Aprindine
Systematic (IUPAC) name
	{3-[2,3-dihydro-1H-inden-2-yl(phenyl)amino]propyl}diethylamine
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	37640-71-4
ATC code	C01BB04
PubChem	CID: 2218
DrugBank	DB01429
ChemSpider	2132
UNII	5Y48085P9Q
KEGG	D02969
ChEMBL	CHEMBL1213033
Chemical data
Formula	C22H30N2
Molecular mass	322.487 g/mol
	SMILES c1cccc3c1CC(N(c2ccccc2)CCCN(CC)CC)C3 ;
	InChI InChI=1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3 ; Key:NZLBHDRPUJLHCE-UHFFFAOYSA-N ;
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