antimalarial agent

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antimalarialantimalarial drugantimalarials

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/06/03 10:54:35」(JST)

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英文文献

  • Natural polyhydroxyalkanoate-gold nanocomposite based biosensor for detection of antimalarial drug artemisinin.
  • Phukon P1, Radhapyari K2, Konwar BK3, Khan R4.Author information 1Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur 784028, Assam, India.2Analytical Chemistry Division, CSIR-North East Institute of Science & Technology, Jorhat 785006, Assam, India.3Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur 784028, Assam, India; Nagaland University (Central), Lumami, Zunheboto, Nagaland 798627, India.4Analytical Chemistry Division, CSIR-North East Institute of Science & Technology, Jorhat 785006, Assam, India. Electronic address: khan.raju@gmail.com.AbstractThe worrisome trend of antimalarial resistance has already highlighted the importance of artemisinin as a potent antimalarial agent. The current investigation aimed at fabricating a biosensor based on natural polymer polyhydroxyalkanoate-gold nanoparticle composite mounting on an indium-tin oxide glass plate for the analysis of artemisinin. The biosensor was fabricated using an adsorbing horse-radish peroxidase enzyme on the electrode surface for which cyclic voltammetry was used to monitor the electro-catalytic reduction of artemisinin under diffusion controlled conditions. Electrochemical interfacial properties and immobilization of enzyme onto a polyhydroxyalkanoate-gold nanoparticle film were evaluated, and confirmed by cyclic voltammetry, electrochemical impedance spectroscopy and scanning electron microscopy. The differential pulse voltammetric peak current for artemisinin was increased linearly (concentration range of 0.01-0.08μgmL(-1)) with sensitivity of 0.26μAμgmL(-1). The greater sensitivity of the fabricated biosensor to artemisinin (optimum limits of detection were 0.0035μgmL(-1) and 0.0036μgmL(-1) in bulk and spiked human serum, respectively) could be of much aid in medical diagnosis.
  • Materials science & engineering. C, Materials for biological applications.Mater Sci Eng C Mater Biol Appl.2014 Apr 1;37:314-20. doi: 10.1016/j.msec.2014.01.019. Epub 2014 Jan 15.
  • The worrisome trend of antimalarial resistance has already highlighted the importance of artemisinin as a potent antimalarial agent. The current investigation aimed at fabricating a biosensor based on natural polymer polyhydroxyalkanoate-gold nanoparticle composite mounting on an indium-tin oxide gl
  • PMID 24582254
  • Glabridin induces oxidative stress mediated apoptosis like cell death of malaria parasite Plasmodium falciparum.
  • Cheema HS1, Prakash O2, Pal A1, Khan F2, Bawankule DU1, Darokar MP3.Author information 1Molecular Bioprospection Department, CSIR- Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow-226 015, India.2Metabolic and Structural Biology Department, CSIR- Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow-226 015, India.3Molecular Bioprospection Department, CSIR- Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow-226 015, India. Electronic address: mpdarokar@yahoo.com.AbstractPlants are known as the source of novel agents for developing new antimalarial drugs. Glabridin is a polyphenolic flavonoid, a main constituent in the roots of Glycyrrhiza glabra possesses various biological activities. However, its anti-plasmodial activity is unexplored. In the present work, it is for the first time demonstrated that glabridin inhibits Plasmodium falciparum growth in vitro with an IC50 23.9±0.43μM. Glabridin showed poor cytotoxicity in vitro with an IC50 246.6±0.88μM against Vero cell line and good selectivity index (9.6). In erythrocytic cycle, trophozoite stage was found to be most sensitive to glabridin. In silico study showed that glabridin inhibits Pf LDH enzyme activity by acting on NADH binding site. Glabridin induced oxidative stress by the generation of reactive oxygen and nitrogen species. Glabridin could induce apoptosis in parasite as evidenced by the depolarization of mitochondrial membrane potential (Δψm), activation of caspase like proteases and DNA fragmentation. These results indicate that glabridin exhibits antiplasmodial activity and is suitable for developing antimalarial agent from a cheap and sustainable source.
  • Parasitology international.Parasitol Int.2014 Apr;63(2):349-58. doi: 10.1016/j.parint.2013.12.005. Epub 2013 Dec 18.
  • Plants are known as the source of novel agents for developing new antimalarial drugs. Glabridin is a polyphenolic flavonoid, a main constituent in the roots of Glycyrrhiza glabra possesses various biological activities. However, its anti-plasmodial activity is unexplored. In the present work, it is
  • PMID 24361284
  • Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to Plasmodium.
  • Urbán P1, Valle-Delgado JJ1, Mauro N2, Marques J1, Manfredi A2, Rottmann M3, Ranucci E2, Ferruti P2, Fernàndez-Busquets X4.Author information 1Nanomalaria Group, Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac 10-12, ES-08028 Barcelona, Spain; Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Rosselló 149-153, ES-08036 Barcelona, Spain; Biomolecular Interactions Team, Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, Martí i Franquès 1, ES-08028 Barcelona, Spain.2Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, IT-20133 Milano, Italy.3Swiss Tropical and Public Health Institute, Socinstrasse 57, PO Box, CH-4002 Basel, Switzerland.4Nanomalaria Group, Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac 10-12, ES-08028 Barcelona, Spain; Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Rosselló 149-153, ES-08036 Barcelona, Spain; Biomolecular Interactions Team, Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, Martí i Franquès 1, ES-08028 Barcelona, Spain. Electronic address: xfernandez_busquets@ub.edu.AbstractCurrent malaria therapeutics demands strategies able to selectively deliver drugs to Plasmodium-infected red blood cells (pRBCs) in order to limit the appearance of parasite resistance. Here, the poly(amidoamines) AGMA1 and ISA23 have been explored for the delivery of antimalarial drugs to pRBCs. AGMA1 has antimalarial activity per se as shown by its inhibition of the in vitro growth of Plasmodium falciparum, with an IC50 of 13.7μM. Fluorescence-assisted cell sorting data and confocal fluorescence microscopy and transmission electron microscopy images indicate that both polymers exhibit preferential binding to and internalization into pRBCs versus RBCs, and subcellular targeting to the parasite itself in widely diverging species such as P. falciparum and Plasmodium yoelii, infecting humans and mice, respectively. AGMA1 and ISA23 polymers with hydrodynamic radii around 7nm show a high loading capacity for the antimalarial drugs primaquine and chloroquine, with the final conjugate containing from 14.2% to 32.9% (w/w) active principle. Intraperitoneal administration of 0.8mg/kg chloroquine as either AGMA1 or ISA23 salts cured P. yoelii-infected mice, whereas control animals treated with twice as much free drug did not survive. These polymers combining into a single chemical structure drug carrying capacity, low unspecific toxicity, high biodegradability and selective internalization into pRBCs, but not in healthy erythrocytes for human and rodent malarias, may be regarded as promising candidates deserving to enter the antimalarial therapeutic arena.
  • Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2014 Mar 10;177:84-95. doi: 10.1016/j.jconrel.2013.12.032. Epub 2014 Jan 7.
  • Current malaria therapeutics demands strategies able to selectively deliver drugs to Plasmodium-infected red blood cells (pRBCs) in order to limit the appearance of parasite resistance. Here, the poly(amidoamines) AGMA1 and ISA23 have been explored for the delivery of antimalarial drugs to pRBCs. AG
  • PMID 24412735

和文文献

  • 抗マラリア剤としてのビタミンB_<12>の可能性
  • 山田 正二,山田 惠子
  • ビタミン 82(9), 507-512, 2008-09-25
  • NAID 110006885121
  • Synthesis and Evaluation of β-Carbolinium Cations as New Antimalarial Agents Based on π-Delocalized Lipophilic Cation (DLC) Hypothesis
  • Takasu Kiyosei,Shimogama Tsubasa,Saiin Chalerm [他],KIM Hye Sook,WATAYA Yusuke,BRUN Reto,IHARA Masataka
  • Chemical & pharmaceutical bulletin 53(6), 653-661, 2005-06-01
  • … Several β-carbolines including naturally occurring substances and their corresponding cationic derivatives were synthesized and evaluated for antimalarial (antiplasmodial) activity in vitro and in vivo. … Quarternary carbolinium cations showed much higher potencies in vitro than electronically neutral β-carbolines and a good correlation was observed between π-delocalized lipophilic cationic (DLC) structure and antimalarial efficacy. …
  • NAID 10016654331
  • Structure of Pyrimethamine Hydrochloride
  • TANAKA Rumiko,ARAI Tomoko,HIRAYAMA Noriaki
  • Analytical Sciences: X-ray Structure Analysis Online 20, X175-X176, 2004
  • … The title compound is an antimalarial agent. …
  • NAID 130004442609

関連リンク

Wikimedia Commons has media related to: Antimalarial agents ... Pages in category "Antimalarial agents". The following 44 pages are in this category, out of 44 total. This list may not reflect recent changes (learn more).

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 major antimalarial agent -- ScienceDailyAntimalarial Agent Natural Sweet Wormwood mumbai maladox is an antimalarial agent  antimalarial agent available as 250 mg an antimalarial agent available as 250-mg antimalarial agent was quinine which took


★リンクテーブル★
先読み抗マラリア薬
リンク元抗マラリア剤」「antimalarial drug
関連記事agent」「age」「antimalarial

抗マラリア薬」

  [★]

antimalarials, antimalarial drug, antimalarial drugs
マラリア治療薬
マラリア



抗マラリア剤」

  [★]

antimalarialantimalarial drugantimalarial agent
抗マラリア抗マラリア薬

antimalarial drug」

  [★]

antimalarialantimalarial agentantimalarials


agent」

  [★]

  • n.
  • 代行者、代理人。代理業者
  • 政府職員、官吏
  • ある後位をする人、ある作用をするもの。動員、動力因、作用因。(文法)動作主。科学的変化を起こさせるもの、薬品、~剤。病原体
agonistagonisticattorneydelegatedrugetiologic agentfomesfomitesmediatorpathogenpathogenicpharmaceutical preparationvectorvehicle

WordNet   license wordnet

「a substance that exerts some force or effect」

WordNet   license wordnet

「a businessman who buys or sells for another in exchange for a commission」
factor, broker

WordNet   license wordnet

「any agent or representative of a federal agency or bureau」
federal agent

WordNet   license wordnet

「a representative who acts on behalf of other persons or organizations」

WordNet   license wordnet

「an active and efficient cause; capable of producing a certain effect; "their research uncovered new disease agents"」

PrepTutorEJDIC   license prepejdic

「『代理人』;周旋人 / 働き(作用)を起こすもの;作用物,薬剤 / (政府機関,特にFBI,CIAなどの)部員,機関員」


age」

  [★]

  • n.
  • v.
  • 加齢する、熟成する
agedageingagingyear old

WordNet   license wordnet

「how long something has existed; "it was replaced because of its age"」

WordNet   license wordnet

「a time of life (usually defined in years) at which some particular qualification or power arises; "she was now of school age"; "tall for his eld"」
eld

WordNet   license wordnet

「begin to seem older; get older; "The death of his wife caused him to age fast"」

WordNet   license wordnet

「make older; "The death of his child aged him tremendously"」

PrepTutorEJDIC   license prepejdic

「〈U〉(一般に)『年齢』,寿命;〈C〉(個々の)『年齢』,年 / 〈U〉成年(おとなとしての資格・権利を得る年齢;通例18または21歳) / 〈U〉『老齢』;《集合的に》老人たち / 〈U〉(人生の)『一時期』;〈C〉世代(generation) / 〈U〉〈C〉《しばしばA-》(歴史上の)『時代』 / 〈C〉《話》長い間 / 年をとる,ふける;〈物が〉古くなる / 〈年〉'を'とらせる;〈物〉'を'古びさせる」


antimalarial」

  [★]

  • adj.
  • 抗マラリアの
  • n.
antimalarial agentantimalarial drugantimalarials

WordNet   license wordnet

「a medicinal drug used to prevent or treat malaria」
antimalarial drug




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