amitriptyline

出典: meddic

アミトリプチリン

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「a tricyclic antidepressant drug (trade name Elavil) with serious side effects; interacts with many other medications」
amitriptyline hydrochloride, Elavil

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/10/08 11:36:52」(JST)

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英文文献

  • New sorbent in the dispersive solid phase extraction step of quick, easy, cheap, effective, rugged, and safe for the extraction of organic contaminants in drinking water treatment sludge.
  • Cerqueira MB1, Caldas SS1, Primel EG2.Author information 1Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande, Rio Grande do Sul, Brazil.2Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande, Rio Grande do Sul, Brazil. Electronic address: eprimelfurg@gmail.com.AbstractRecent studies have shown a decrease in the concentration of pesticides, pharmaceuticals and personal care products (PCPs) in water after treatment. A possible explanation for this phenomenon is that these compounds may adhere to the sludge; however, investigation of these compounds in drinking water treatment sludge has been scarce. The sludge generated by drinking water treatment plants during flocculation and decantation steps should get some special attention not only because it has been classified as non-inert waste but also because it is a very complex matrix, consisting essentially of inorganic (sand, argil and silt) and organic (humic substances) compounds. In the first step of this study, three QuEChERS methods were used, and then compared, for the extraction of pesticides (atrazine, simazine, clomazone and tebuconazole), pharmaceuticals (amitriptyline, caffeine, diclofenac and ibuprofen) and PCPs (methylparaben, propylparaben, triclocarban and bisphenol A) from drinking water treatment sludge. Afterwards, the study of different sorbents in the dispersive solid phase extraction (d-SPE) step was evaluated. Finally, a new QuEChERS method employing chitin, obtained from shrimp shell waste, was performed in the d-SPE step. After having been optimized, the method showed limits of quantification (LOQ) between 1 and 50μgkg(-1) and the analytical curves showed r values higher than 0.98, when liquid chromatography tandem mass spectrometry was employed. Recoveries ranged between 50 and 120% with RSD≤15%. The matrix effect was evaluated and compensated with matrix-matched calibration. The method was applied to drinking water treatment sludge samples and methylparaben and tebuconazole were found in concentration <LOQ.
  • Journal of chromatography. A.J Chromatogr A.2014 Apr 4;1336:10-22. doi: 10.1016/j.chroma.2014.02.002. Epub 2014 Feb 8.
  • Recent studies have shown a decrease in the concentration of pesticides, pharmaceuticals and personal care products (PCPs) in water after treatment. A possible explanation for this phenomenon is that these compounds may adhere to the sludge; however, investigation of these compounds in drinking wate
  • PMID 24582392
  • Socioeconomic deprivation independently predicts symptomatic painful diabetic neuropathy in type 1 diabetes.
  • Anderson SG1, Malipatil NS2, Roberts H2, Dunn G3, Heald AH4.Author information 1Cardiovascular Sciences Research Group, Core Technology Facility (3rd Floor), University of Manchester, 46 Grafton Street, Manchester, United Kingdom.2Department of Medicine, Leighton Hospital, Crewe, United Kingdom.3Podiatry, East Cheshire NHS Trust, Macclesfield, United Kingdom.4Department of Medicine, Leighton Hospital, Crewe, United Kingdom; School of Medicine and Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom. Electronic address: adrian.heald@manchester.ac.uk.AbstractINTRODUCTION: Painful peripheral neuropathy in people with type 1 diabetes is a disabling and costly complication. A greater understanding of predisposing factors and prescribing may facilitate more effective resource allocation.
  • Primary care diabetes.Prim Care Diabetes.2014 Apr;8(1):65-9. doi: 10.1016/j.pcd.2013.08.004. Epub 2013 Nov 8.
  • INTRODUCTION: Painful peripheral neuropathy in people with type 1 diabetes is a disabling and costly complication. A greater understanding of predisposing factors and prescribing may facilitate more effective resource allocation.METHODS: The Townsend index of deprivation (numerically higher for grea
  • PMID 24211151
  • Determination of the cationic amphiphilic drug-DNA binding mode and DNA-assisted fluorescence resonance energy transfer amplification.
  • Yaseen Z1, Banday AR2, Hussain MA2, Tabish M2, Kabir-Ud-Din3.Author information 1Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India. Electronic address: zadn521@gmail.com.2Department of Biochemistry, Aligarh Muslim University, Aligarh 202002, India.3Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India. Electronic address: kabir7@rediffmail.com.AbstractUnderstanding the mechanism of drug-DNA binding is crucial for predicting the potential genotoxicity of drugs. Agarose gel electrophoresis, absorption, steady state fluorescence, and circular dichroism have been used in exploring the interaction of cationic amphiphilic drugs (CADs) such as amitriptyline hydrochloride (AMT), imipramine hydrochloride (IMP), and promethazine hydrochloride (PMT) with calf thymus or pUC19 DNA. Agarose gel electrophoresis assay, along with absorption and steady state fluorescence studies, reveal interaction between the CADs and DNA. A comparative study of the drugs with respect to the effect of urea, iodide induced quenching, and ethidium bromide (EB) exclusion assay reflects binding of CADs to the DNA primarily in an intercalative fashion. Circular dichroism data also support the intercalative mode of binding. Besides quenching, there is fluorescence exchange energy transfer (FRET) in between CADs and EB using DNA as a template.
  • Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2014 Mar 25;122:553-64. doi: 10.1016/j.saa.2013.11.030. Epub 2013 Nov 16.
  • Understanding the mechanism of drug-DNA binding is crucial for predicting the potential genotoxicity of drugs. Agarose gel electrophoresis, absorption, steady state fluorescence, and circular dichroism have been used in exploring the interaction of cationic amphiphilic drugs (CADs) such as amitripty
  • PMID 24334019

和文文献

  • Tricyclic Antidepressant Amitriptyline Indirectly Increases the Proliferation of Adult Dentate Gyrus-Derived Neural Precursors: An Involvement of Astrocytes
  • Boku Shuken,Hisaoka-Nakashima Kazue,Nakagawa Shin,Kato Akiko,Kajitani Naoto,Inoue Takeshi,Kusumi Ichiro,Takebayashi Minoru
  • Plos one 8(11), e79371, 2013-11-18
  • … We have also shown that amitriptyline (AMI), a tricyclic antidepressant, induces the expressions of GDNF, BDNF, FGF2 and VEGF, common neurogenic factors, in primary cultured astrocytes (PCA). …
  • NAID 120005365918
  • 回復期病棟入院患者の頻尿に対するアミトリプチリンの有効性の検討
  • 中木村 繁,吉田 聖子,藤原 郁子 [他]
  • 総合リハビリテーション 41(2), 187-190, 2013-02
  • NAID 40019568053
  • 夜尿症児90例の臨床的検討
  • 村杉 寛子,永木 茂,大澤 眞木子,MURASUGI Hiroko,NAGAKI Shigeru,OSAWA Makiko
  • 東京女子医科大学雑誌 83(E1), E205-E211, 2013-01-31
  • 夜尿症90例の臨床検討を行った. 初診時年齢の分布は,6歳と9歳に2峰性のピークがみられ,男女比1.7:1,男児に多くみられる傾向にあった.一次性夜尿は88例,二次性夜尿は2例.病型分類できた83例のうち多尿型41例(49.4%),混合型42例(50.6%)であった.治療の選択薬剤は抗利尿ホルモン 44例, 抗コリン薬40例,三環系抗うつ薬34例,またアラームは4例で使用した(重複あり).生活指導 …
  • NAID 110009559379

関連リンク

Amitriptyline is a tricyclic antidepressants and is used is used to treat symptoms of depression. Learn about side effects, interactions and indications. ... Amitriptyline side effects Get emergency medical help if you have any of these ...
Amitriptyline - Amitriptyline is a tricyclic antidepressant. Amitriptyline affects chemicals in the brain that may become unbalanced. - You should not use this medication if you are allergic to amitriptyline, or if you have recently had a ...

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★リンクテーブル★
リンク元薬理学」「抗うつ薬」「三環系抗うつ薬」「アミトリプチリン
拡張検索amitriptyline hydrochloride

薬理学」

  [★]

pharmacology
drug entries


定義

  • 生物系と化学物質の選択的な相互作用を研究する学問 (SPC.2)

生物系と薬の相互作用

  • 薬の生物系に対する相互作用:薬理作用 <-化学の視点
  • 生物系の薬に対する相互作用:薬物動態 <-生物の視点

関連分野

  • 薬物学 materia medica
  • 生薬学
  • 実験薬理学
  • 臨床薬理学
  • 動物薬理学
  • 人体薬理学
  • 比較薬理学
  • 薬理作用学(薬力学)
  • 薬物動態学
  • 中毒学、毒科学
  • 薬物治療学
  • 処方学

薬品の命名

Ending of the drug name Category Example
~afil Erectile dysfunction sildenafil
~ane Inhalatinal general anesthetic halothane
~azepam Benzodiaizepine diazepam
~azine Phenothiazine (neuroleptic, antiemetic) chlorpromazine
~azole Ailtifungal ketoconazole
~barbital Barbiturate phenobarbital
~caine Local anesthetic lidocaine
~cillin Penicillin methicillin
~cycline Antibiotic, protein syntlesis inhibitor tetracycline
~ipramine TCA iimipramine
~navir Protease inhibitor saquinavir
~olol β-antagonist propranolol
~operidol Butyrophenone ( neuroleptic ) haloperidol
~oxin Cardiac glycoside ( inotropic agent ) digoxin
~phylline Methylxanthine theophylline
~pril ACE inhibitor captopril
~terol β2 agonist albuterol
~tidine H2 antagonist cimtidine
~triptyline TCA amitriptyline
~tropine Pituitary hormone somatotropine
~zosin a1 antagonist prazosin

薬一覧

薬物代謝

薬理動態

神経伝達物質

神経筋接合部遮断薬(筋弛緩薬)

交感神経作動薬

アドレナリン受容体

交感神経遮断薬

アドレナリン受容体

副交感神経作動薬

アセチルコリン受容体

副交感神経遮断薬

アセチルコリン受容体

貧血治療薬

甲状腺関連物質

痛風治療薬

  • 痛風発作予防薬
  • 尿酸排泄促進薬
  • 尿酸生成抑制薬


抗うつ薬」

  [★]

antidepressant, antidepressants
薬理学、そううつ病、精神疾患

作用機序

三環系抗うつ薬 tricyclic antidepressant

  • 2つの説がある。
  • 1. (急性作用)シナプス前膜におけるノルアドレナリン、セロトニンの再取り込み↓→シナプス間隙における薬剤濃度↑
  • 2. (慢性作用)(2週間後)シナプス後膜における受容体の数↓
  • 慢性作用はシナプス間隙のノルアドレナリン、セロトニン濃度が上昇した結果、シナプス後膜の受容体が減少したために出現すると考えられる。

抗うつ薬

  • 三環系
  • 四環系
ミルナシプラン milnacipran
  • 非定型抗うつ薬 atypical agent




三環系抗うつ薬」

  [★]

tricyclic antidepressant, tricyclic anti-depressant agent
抗うつ薬四環系抗うつ薬
イミプラミン

概念

  • 環状の構造を三つ持つ抗うつ薬
  • 治療効果発現には2-3週間必要

種類

作用機序

副作用

  • 抗コリン作用
視力障害、口渇、便秘、尿閉
頻脈
  • α1ブロック作用
起立性低血圧
血中ノルアドレナリンの上昇
  • 抗ヒスタミン作用
鎮静、眠気



アミトリプチリン」

  [★]

amitriptyline
塩酸アミトリプチリン amitriptyline hydrochloride
アミプリントリプタノールラントロンノーマルン
抗うつ薬
精神神経用剤



amitriptyline hydrochloride」

  [★]

Elavil, Emitrip, Endep




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