alkylphosphocholine

アルキルホスホコリン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/29 18:41:33」(JST)

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Alkylphosphocholines are phospholipid-like molecules that have been synthesised, which have remarkable biological and therapeutic activities. They are phosphocholine esters of aliphatic long chain alcohols differing in chain length, Unsaturation and position of the cis-double bond.

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• 1. 皮膚リーシュマニア症の治療 treatment of cutaneous leishmaniasis

English Journal

• Alkylphosphocholines for intraocular lens coating.

• Eibl KH, Wertheimer C, Kernt M, Wolf A, Kook D, Haritoglou C, Kampik A.SourceFrom the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany. Electronic address: kirsten.eibl@med.uni-muenchen.de.
• Journal of cataract and refractive surgery.J Cataract Refract Surg.2013 Mar;39(3):438-45. doi: 10.1016/j.jcrs.2012.09.028. Epub 2013 Jan 11.
• PURPOSE: To assess the effect of alkylphosphocholine (APC)-coated intraocular lenses (IOLs) on human lens epithelial cell (LEC) proliferation in vitro and the corneal biocompatibility of APC in an organ culture model of human donor eyes.SETTING: Research Laboratory for Experimental Ophthalmology, L
• PMID 23317779

• Effect of alkylphospholipids on Candida albicans biofilm formation and maturation.

• Vila TV, Ishida K, de Souza W, Prousis K, Calogeropoulou T, Rozental S.SourceLaboratório de Biologia Celular de Fungos, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho 373, Bloco C/sub-solo, Sala C0-026, Cidade Universitária, 21.941-902 Rio de Janeiro, Brazil.
• The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2013 Jan;68(1):113-25. doi: 10.1093/jac/dks353. Epub 2012 Sep 19.
• OBJECTIVES: The aim of this study was to evaluate miltefosine and four synthetic compounds (TCAN26, TC19, TC106 and TC117) for their in vitro inhibitory activity against Candida albicans planktonic and biofilm cells and investigate whether these compounds are able to inhibit the biofilm formation an
• PMID 22995097

• Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis.

• Dorlo TP, Balasegaram M, Beijnen JH, de Vries PJ.SourceCenter for Tropical Medicine and Travel Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. thomasdorlo@gmail.com
• The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2012 Nov;67(11):2576-97. doi: 10.1093/jac/dks275. Epub 2012 Jul 24.
• Miltefosine is an alkylphosphocholine drug with demonstrated activity against various parasite species and cancer cells as well as some pathogenic bacteria and fungi. For 10 years it has been licensed in India for the treatment of visceral leishmaniasis (VL), a fatal neglected parasitic disease. It
• PMID 22833634

Japanese Journal

• Quantification of CLR1401, a novel alkylphosphocholine anticancer agent, in rat plasma by hydrophilic interaction liquid chromatography-tandem mass spectrometric detection

• JIANG Hongliang,CANNON Michelle J.,BANACH Maria,PINCHUK Anatoly N.,TON Giangthy N.,SCHEUERELL Christie,LONGINO Marc A.,WEICHERT Jamey P.,TOLLEFSON Richard,CLARKE William R.,JI Qin C.,JIANG Xiangyu
• Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 878(19), 1513-1518, 2010-06-01
• NAID 10028037121

• Quantification of erufosine, the first intravenously applicable alkylphosphocholine, in human plasma by isotope dilution liquid chromatography-tandem mass spectrometry using a deuterated internal standard

• LINDNER Lars H.,EIBL Hansjoerg,HOSSANN Martin,VOGESER Michael
• Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 869(1), 16-19, 2008-06-15
• NAID 10028001872

• Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine

• HANSON P. K.
• J Biol Chem 278, 36041-36050, 2003
• NAID 80016234005

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• Alkylphosphocholine - Wikipedia, the free encyclopedia

Alkylphosphocholine. From Wikipedia, the free encyclopedia. Jump to: navigation , search. Alkylphosphocholines are phospholipid-like molecules that have been synthesised, which have remarkable biological and therapeutic activities.

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