alkylating agents

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/08/30 19:08:10」(JST)

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  • Severe adverse events from the treatment of advanced melanoma: a systematic review of severe side effects associated with ipilimumab, vemurafenib, interferon alfa-2b, dacarbazine and interleukin-2.
  • Ma C1, Armstrong AW.
  • The Journal of dermatological treatment.J Dermatolog Treat.2014 Oct;25(5):401-8. doi: 10.3109/09546634.2013.813897. Epub 2013 Jul 3.
  • BACKGROUND: Current immunomodulatory agents for stage III and IV melanoma exert different mechanisms of action that manifest in distinct adverse events.OBJECTIVE: This systematic review aims to synthesize safety data from clinical trials on ipilimumab, vemurafenib, interferon (IFN) alfa-2b, dacarbaz
  • PMID 23763243
  • Secondary malignant neoplasms after high-dose chemotherapy and autologous stem cell rescue for high-risk neuroblastoma.
  • Martin A1, Schneiderman J, Helenowski IB, Morgan E, Dilley K, Danner-Koptik K, Hatahet M, Shimada H, Cohn SL, Kletzel M, Hijiya N.
  • Pediatric blood & cancer.Pediatr Blood Cancer.2014 Aug;61(8):1350-6. doi: 10.1002/pbc.25033. Epub 2014 Mar 14.
  • BACKGROUND: Outcomes for high-risk neuroblastoma remain poor. Modern treatment protocols utilizing intense induction followed by myeloablative consolidation chemotherapy with autologous stem cell rescue (ASCR) have improved survival rates, but the long-term sequelae, including development of seconda
  • PMID 24634399


  • Acute Myeloid Leukemia Diagnosed 5 Years after Adult T-Cell Leukemia/Lymphoma
  • Journal of Clinical and Experimental Hematopathology 55(1), 29-31, 2015
  • NAID 130005083790
  • グリオーマの遺伝子異常に基づいた化学療法の最新知見


The alkylating agents were the first nonhormonal drugs to be used effectively in the treatment of cancer, and the story behind the recognition of the antitumor effects of these compounds is a remarkable one. During World War I, toxic ...
These medicines bind to cellular DNA and interfere with chromosome division. Stopping cell division stops the growth of cancers. ... Occasionally severe organ damage can occur with the administration of alkylating agents.


alkylating agents antimetabolites dna Alkylating agents were one of the earliest Alkylating AgentsFigure 1. Alkylating agents can damage




alkylating agent, alkylating agents




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