acyl carrier protein

アシルキャリアータンパク質

WordNet

1. an inactive substance that is a vehicle for a radioactive tracer of the same substance and that assists in its recovery after some chemical reaction
2. (genetics) an organism that possesses a recessive gene whose effect is masked by a dominant allele; the associated trait is not apparent but can be passed on to offspring
3. a rack attached to a vehicle; for carrying luggage or skis or the like
4. a self-propelled wheeled vehicle designed specifically to carry something; "refrigerated carriers have revolutionized the grocery business"
5. someone whose employment involves carrying something; "the bonds were transmitted by carrier" (同)bearer, toter
6. a person or firm in the business of transporting people or goods or messages (同)common_carrier
7. (medicine) a person (or animal) who has some pathogen to which he is immune but who can pass it on to others (同)immune carrier
8. a boy who delivers newspapers (同)newsboy
9. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
10. any group or radical of the form RCO- where R is an organic group; "an example of the acyl group is the acetyl group" (同)acyl_group

PrepTutorEJDIC

1. 『運搬する人』;輸送業者(会社) / 運搬する物,運客車;運客設備 / (…の)媒介体,保菌者《+『of』+『名』》 / (また『aircraft carrier』)航空母艦 / (自転車・車の)荷台
2. 蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/08 20:16:05」(JST)

wiki en

[Wiki en表示]

Streptomyces coelicolor actinorhodin polyketide synthase acyl carrier protein - PDB: 2AF8​

The acyl carrier protein (ACP) is an important component in both fatty acid and polyketide biosynthesis with the growing chain bound during synthesis as a thiol ester at the distal thiol of a 4'-phosphopantetheine moiety. The protein is expressed in the inactive apo form and the 4'-phosphopantetheine moiety must be post-translationally attached to a conserved serine residue on the ACP by the action of holo-acyl carrier protein synthase (ACPS), a phosphopantetheinyl transferase.

4'-Phosphopantetheine is an essential prosthetic group of several acyl carrier proteins involved in pathways of primary and secondary metabolism including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, and peptidyl carrier proteins (PCP) and aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). Phosphopantetheine fulfills two demands in these biosynthetic pathways. First, the intermediates remain covalently linked to the synthases (or synthetases) in an energy-rich linkage. Second, the flexibility and length of the phosphopantetheine chain (approximately 2 nm) allows the covalently tethered intermediates to have access to spatially distinct enzyme-active sites. This increases the effective molarity of the intermediate and allows an assembly line-like process.

The ACPs are small negatively charged α-helical bundle proteins with a high degree of structural and amino acid similarity. The structures of a number of acyl carrier proteins have been solved using various NMR and crystallography techniques.

The ACPs are related in structure and mechanism to the peptidyl carrier proteins (PCP) from nonribosomal peptide synthases.

External links

• Acyl Carrier Protein at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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• 1. 脂質およびプリン代謝障害による代謝性ミオパチー metabolic myopathies caused by disorders of lipid and purine metabolism
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• 4. プロテインS欠乏症：臨床症状および診断 protein s deficiency clinical manifestations and diagnosis
• 5. 幼児の食物蛋白誘発性直腸炎/大腸炎および腸疾患 food protein induced proctitis colitis and enteropathy of infancy

English Journal

• The structural role of the carrier protein - active controller or passive carrier.

• Crosby J, Crump MP.SourceSchool of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
• Natural product reports.Nat Prod Rep.2012 Oct 12;29(10):1111-37. Epub 2012 Aug 24.
• Covering: 2007 to 2011. Previous review: Nat. Prod. Rep., 2007, 24, 750Common to all FASs, PKSs and NRPSs is a remarkable component, the acyl or peptidyl carrier protein (A/PCP). These take the form of small individual proteins in type II systems or discrete folded domains in the multi-domain type I
• PMID 22930263

• Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria.

• Halavaty AS, Kim Y, Minasov G, Shuvalova L, Dubrovska I, Winsor J, Zhou M, Onopriyenko O, Skarina T, Papazisi L, Kwon K, Peterson SN, Joachimiak A, Savchenko A, Anderson WF.SourceCenter for Structural Genomics of Infectious Diseases, USA.
• Acta crystallographica. Section D, Biological crystallography.Acta Crystallogr D Biol Crystallogr.2012 Oct;68(Pt 10):1359-70. Epub 2012 Sep 13.
• Some bacterial type II fatty-acid synthesis (FAS II) enzymes have been shown to be important candidates for drug discovery. The scientific and medical quest for new FAS II protein targets continues to stimulate research in this field. One of the possible additional candidates is the acyl-carrier-pro
• PMID 22993090

Japanese Journal

• <i>in silico</i> Structure-Based Drug Screening手法を用いた<i>Mycobacterium</i>に対する新規抗菌作用化合物の同定

• 金城 知広,小関 祐司,山田 淳美,出水園優也 ,アリィヴァロ 志穂,小林 舞子,青木 俊介
• 情報処理学会研究報告. BIO, バイオ情報学 2012-BIO-30(9), 1-2, 2012-08-02
• … in silico structure-based drug screening手法を用いて結核菌enoyl-acyl carrier protein reductaseに対する新規抗菌剤の同定を行った.その結果,モデル細菌Mycobacterium smegmatisに対して安定的な抗菌作用を示し,かつ腸内モデル細菌と哺乳類モデル細胞に対して有意な毒性がない2化合物が同定された. …
• NAID 110009432497

• Chalcomoracin and Moracin C, New Inhibitors of Staphylococcus aureus Enoyl-Acyl Carrier Protein Reductase from Morus alba

• Kim Yu Jin,Sohn Mi-Jin,Kim Won-Gon
• Biological & pharmaceutical bulletin 35(5), 791-795, 2012-05
• NAID 40019233791

Related Links

• Acyl carrier proteinとは - goo Wikipedia (ウィキペディア)

The acyl carrier protein (ACP) is an important component in both fatty acid and polyketide biosynthesis with the growing chain bound during synthesis as a thiol ester at the distal thiol of a 4'-phosphopantethiene moiety. The protein is ...

• acpP - Acyl carrier protein - Escherichia coli (strain K12)

Carrier of the growing fatty acid chain in fatty acid biosynthesis. ... 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in ...

Related Pictures

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★リンクテーブル★

リンク元	「アシルキャリアータンパク質」
拡張検索	「enoyl-(acyl-carrier protein) reductase」「acyl-carrier protein S-acetyltransferase」「acyl-carrier protein S-malonyltransferase」「3-oxoacyl-(acyl-carrier-protein) synthase」
関連記事	「carrier」

「アシルキャリアータンパク質」

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英

acyl carrier protein, ACP

同

アシルキャリアータンパク

「enoyl-(acyl-carrier protein) reductase」

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エノイルアシルキャリアータンパク質還元酵素、エノイルアシルキャリアータンパク質レダクターゼ

関

enoyl-ACP reductase

「acyl-carrier protein S-acetyltransferase」

　　[★]

アシルキャリアータンパク質-S-アセチル基転移酵素、アシルキャリアータンパク質-S-アセチルトランスフェラーゼ

「acyl-carrier protein S-malonyltransferase」

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アシルキャリアータンパク質-S-マロニルトランスフェラーゼ

関

malonyl transacylase

「3-oxoacyl-(acyl-carrier-protein) synthase」

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3-オキソアシル・アシルキャリアータンパク質合成酵素

「carrier」

　　[★]

• n.

• 運搬体